Clinical analysis of serum and pleural effusion inflammatory and specific indexes in children of mycoplasma pneumonia complicated with pleural effusion

Abstract

Objective To investigate the changes of serum and pleural effusion inflammatory indexes in children with mycoplasma pneumoniae complicated with pleural effusion. Methods Enzyme linked immunosorbent assay (ELISA) double antibody sandwich method was used in the three of pleural effusion group, mycoplasma pneumonia group, control group and other groups to detect serum and pleural effusion human interleukin 6 (IL-6). human interleukin 2 (IL-2) and TNF-(human tumor necrosis factor alpha) etc.Inflammation index levels were detected and compared. Results The group of patients with mycoplasma pneumonia mycoplasma pneumonia patients was (9.93±1.05)pg/mL for the IL-6 level, IL-2 levels for (4.93±0.55)μg/mL, (1.45±0.17) ng/mL for the TNF alpha level, which were significantly higher than those of the control group, the IL-2 was significantly lower than that of the control group, with statistically significant difference (t=6.25, 5.88, 4.63, 5.95, 3.69, 5.95, all P<0.05). Comparing pleural effusion group and mycoplasma pneumonia group, we found serum IL-6, TNF alpha levels of pleural effusion group were significantly higher than that of mycoplasma pneumonia group, while IL-2 was lower than that in group mycoplasma pneumonia, with statistically significant difference (t=4.02, 3.06, 3.06 and 2.88, all P<0.05). The levels of serum IL-6, IL-2 and TNF-in the serum of patients with different effusion levels were significantly different from the other two groups (all P<0.05). Pleural effusion IL-6 and TNF level of pleural effusion group and mycoplasma pneumonia patients was significantly higher than those of the control group and IL-2 were significantly lower than that of the control group, the difference had statistical significance (t=5.69, 3.69, 602, 4.11, 2.94, 3.67, all P<0.05). Pleural effusion pleural effusion IL-6 and TNF levels were significantly higher than those in the mycoplasma pneumonia group and IL-2 were significantly lower than that in mycoplasma pneumonia group, the difference had statistical significance (t=3.58, 4.13, 3.21, all P<0.05). The inflammatory indexes of patients with different effusion volume could be found in the pleural effusion, in patients with a large number of pleural effusion, the IL-2, IL-6 and TNF-levels compared with the other two groups showed significantly different (t=6.11、5.44、4.82, all P<0.05). Conclusion IL-6, IL-2 and TNF alpha in the occurrence and development of mycoplasma pneumoniae pneumonia play an important role.Suffering from mycoplasma pneumonia in patients with pleural effusion, whoseTNF-and IL-6 inflammatory index and serum indexes are abnormal, is of certain clinical practical value for clinical diagnosis, treatment and prognosis, as the indicator of the development and prognosis of pneumonia and pleural effusion. Key words: Pneumonia, mycoplasma; Pleural effusion; Serum Inflammatory index