Abstract
Human growth and development are controlled by genetic materials. Manipulation of intrinsic genetic mechanisms may, therefore, provide opportunities to intervene in the aging process. One possible strategy for genetic manipulation is to target mRNA. To regulate the cytoplasmic level of mRNA, precise control of the rates of RNA synthesis and degradation is required. This can be achieved by using RNAi, which is a mechanism of gene regulation conserved in plant cells and mammalian cells. SiRNA is one of the RNA duplexes that can mediate RNAi. Because the action of siRNA is highly specific and efficient, this technology has not only facilitated the elucidation of the roles of players involved in the aging network, but has also enabled the life span and the aging process to be modulated at the genetic level. In this chapter, we will highlight the opportunities and challenges of using RNAi for the design and development of biogerontological interventions.
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