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Abstract
Since the first implementation of larval zebrafish in a high-throughput screening format in 2000, zebrafish chemical screens have expanded significantly to encompass a wide range of fish models, targeted pathways and downstream readouts. A survey of the existing literature from 2000 to 2017 identified 114 zebrafish chemical screens. In this chapter we present an overview of zebrafish chemical screening over the past 17 years, categorizing the identified screens by the pathway investigated, the type of fish screened and the compound library used. We examine key findings and clinical implications of notable screens, and discuss limitations as well as recent technological improvements that offer potential solutions.
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