Abstract
The zebrafish lateral line is a sensory system used to detect changes in water flow. It is made up of sensory organs called neuromasts, which are comprised of clusters of mechanosensory hair cells, nonsensory support cells, and their neural connections. This system is initially established by a migratory column of cells called a primordium, which travels down the surface of the fish depositing neuromasts in its wake. A complex network of chemokine, Wnt, and FGF signaling mediates primordium migration and neuromast deposition, and Notch-mediated lateral inhibition is responsible for hair cell specification. As zebrafish age, the lateral line expands to accommodate the increased size of the fish. Furthermore, the hair cells of the lateral line are able to regenerate after damage. New hair cells arise from the proliferation and differentiation of the surrounding support cells. The lateral line has proven to be an excellent system in which to study cell migration, sensory development, and regeneration.
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