Abstract
This chapter provides the reader new to physiologically based pharmacokinetic (PBPK) modeling a perspective on the evolution of this computational tool for use in chemical toxicology and how to get started learning PBPK modeling with a hands-on exercise. A step-by-step process is presented to learn the components of a PBPK model that represent the body of a given species and how the chemical-specific information is used in a PBPK model. Rate equations for compartments that represent the body are discussed along with equations used to simulate chemical exposures via inhalation, intravenous administration, and oral bolus administration (laboratory animals). The computer software code is provided for a PBPK model written in Magnolia freeware for the chemical trichloroethylene (TCE). Rats are exposed to TCE via inhalation or intravenous administration. Step-by-step exercises are presented for the beginner to experience the wonderful world of simulation.
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