Abstract
The frequently occurring neurological diseases with vascular and degenerative origin affect millions of people worldwide. The pathologies cause extensive damage to neurons in specific brain regions, resulting in severe loss of sensory, motor, and cognitive functions.Transient receptor potential (TRP) genes encode a large family of proteins. The TRP family of proteins form tetrameric, nonselective cation channels that can be excited by a variety of physical and chemical stimuli. Activator ligands change the channel protein conformation at different binding sites, leading to channel opening. Channels influence calcium signaling, which regulates various cellular functions.In the present study, we review the most common neurological disorders (stroke, migraine, Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy) in which a modulatory role of TRP channels is suspected in the pathomechanisms.
Published Version
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