Abstract
Fibrosis is commonly characterized by the extensive accumulation of extracellular matrix components during wound healing in response to tissue injury, and can lead to distortion of tissue architecture and loss of organ function. Fibrogenesis is a highly orchestrated process determined by defined sequences of molecular signals and cellular response mechanisms. Understanding the molecular mechanisms have advanced the prospect of developing therapies for disease regression. Recently, extracellular vesicles (EVs) have attracted considerable attention in fibrosis research. In this chapter, we summarize the current knowledge of the involvement of EVs in fibrotic diseases including liver, lung and heart. We also propose EV-based biomarkers and treatments in fibrotic diseases.
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