Abstract
Polylactic-co-glycolic acid (PLGA) is a biodegradable copolymer. It has many applications in the pharmaceuticals and biomedical industries, but its degradation and stability is a major concern. The objective of this study was to evaluate the influence of the Trivedi Effect® on the physicochemical and thermal properties of PLGA using modern analytical techniques. The PLGA sample was divided into control and Biofield Energy Treated parts. The control sample did not obtain the Biofield Energy Treatment, whereas the treated PLGA was received the Trivedi Effect®-Consciousness Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Alice Branton. The particle size values of the treated PLGA were increased by 8.97%(d10), 8.79%(d50), 4.72%(d90), and 6.61%{D(4,3)}; thus, the surface area of treated PLGA was significantly decreased by 6.84% compared with the control sample. The latent heat of evaporation and fusion of the treated PLGA were significantly increased by 29.60% and 230.93%, respectively compared with the control sample. The residue amount was significantly increased by 21.99% in the treated PLGA compared to the control sample. The maximum thermal degradation temperature of the treated PLGA was increased by 2.30% compared with the control sample. It was concluded that the Trivedi Effect®-Consciousness Energy Healing Treatment might have generated a new form of PLGA which may show better powder flow ability, thermal stability, and minimize the hydrolysis of the ester linkages of PLGA. This improved quality of PLGA would be a better choice for the pharmaceutical formulations (i.e., the drug like simvastatin, amoxicillin, and minocycline loaded PLGA nanoparticles) and manufacturing of biomedical devices, i.e., grafts, sutures, implants, surgical sealant films, prosthetic devices, etc., in the industry using it as a raw material.
Highlights
Polylactic-co-glycolic acid (PLGA) is a synthetic copolymer of two different monomers, lactic acid, and glycolic acid
Particle Size Analysis (PSA) The particle size analysis (PSA) analysis of both the control and Biofield Energy Treated PLGA were performed, and the calculated results are presented in Table 1.The particle size values of the control sample at d10, d50, d90, and D(4,3) were 123.36 μm, 393.83 μm, 864.9μm, and 451.581 μm, respectively
The Trivedi Effect®-Consciousness Energy Healing Treatment have a significant impact on the particle size, surface area, and thermal behaviors of PLGA
Summary
Polylactic-co-glycolic acid (PLGA) is a synthetic copolymer of two different monomers, lactic acid, and glycolic acid. It has a great deal of attention in research and development as an alternative biodegradable polymer which has constant biodegradation rate, mechanical resistance, and regular individual chain geometry[1]. PLGA on hydrolysis of its ester linkages in the presence of water releases the monomers. These two monomers under normal physiological conditions are the by-products of various metabolic pathways in the body, minimum systemic toxicity. Higher the content of glycolide units in the PLGA, lower the time required for degradation. PLGA is more useful for the designing of better pharmaceuticals formulations, i.e., the drug like simvastatin, amoxicillin, vancomycin, and minocycline loaded PLGA nanoparti-
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