Abstract
Validation of an HPLC Method Devised for the Quantitative Determination of Ropivacaine in Drug-Delivery Systems
Highlights
Local anesthetics are used to alleviate or eliminate acute and chronic pain[1,2,3]
In vitro release kinetics of the RVC drug-delivery system The in vitro release test was performed in order to evaluate the previously validated methodology, and to determine the release profile of RVC from the liposomal and cyclodextrin-based drug-delivery systems (DDS)[20]
In order to enhance the action of RVC aiming at its clinical application, our group has successfully described the use of liposomes and cyclodextrin-based DDS[4,9,19,22-24]
Summary
Local anesthetics are used to alleviate or eliminate acute and chronic pain[1,2,3]. Ropivacaine (RVC) is a long acting local anesthetic with a chemical structure closely related to other amino-amides cyclic agents: mepivacaine and bupivacaine[3,4]. The validated method was applied to determine the in vitro release profile of RVC from two (liposomal and HP-βCD-based) DDS formulations. Samples of the two DDS (RVC: HP-βCD and LUVRVC) containing 8 mM ropivacaine each, were diluted in HEPES buffer pH 7.0 to three levels of concentration (0.66 mM = 80%, 0.83 mM = 100% and 0.99 mM = 120%).
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