Abstract
Simple SummaryMycotoxins in feeds can cause detrimental effects on the growth performance and health of pigs. One of the methods used to overcome the negative effects of mycotoxins in animal feeds is to add toxin sequestering agents to feed. The present work was conducted to determine the efficacy of mycotoxin sequestering agents using an in vitro method. All mycotoxin sequestering agents effectively bound to aflatoxin B1; only activated charcoal effectively sequestered deoxynivalenol; and a bentonite product, an aluminosilicate product, and activated charcoal effectively sequestered zearalenone.The objective of this study was to determine the efficacy of mycotoxin sequestering agents for aflatoxin B1 (AFB1), deoxynivalenol (DON), and zearalenone (ZEA) using an in vitro method. The twelve toxin sequestering agents tested were seven bentonite products (bentonite A, B, C, D, E, F, and G), two aluminosilicate products (aluminosilicate A and B), a heulandite product, an activated charcoal product, and a yeast cell wall product. A two-step in vitro procedure was employed to mimic the conditions of temperature, pH, and digestive enzymes in the stomach and small intestine of pigs. All mycotoxin sequestering agents tested were able to bind to AFB1 with a high efficacy (>92%). The DON sequestering rate of activated charcoal (99.1%) was greater (p < 0.05) than that of other products. The ZEA sequestering rate of bentonite F (97.0%), aluminosilicate A (99.6%), and activated charcoal (100.0%) was the greatest (p < 0.05) among the tested mycotoxin sequestering agents. Overall, most mycotoxin sequestering agents had the ability to bind to AFB1, but most products, except activated charcoal, failed to sequester DON and ZEA.
Highlights
Mycotoxins in feeds can have detrimental effects on the growth performance and health of pigs [1,2,3]
Aflatoxin is produced by Aspergillus fungi, and DON and ZEA are generated by Fusarium fungi
In vitro procedures mimicking the conditions in the stomach and the small intestine of pigs [12] are available for testing mycotoxin sequestering products [13,14,15,16,17,18]
Summary
Mycotoxins in feeds can have detrimental effects on the growth performance and health of pigs [1,2,3]. Meta-analyses on the influence of mycotoxins in swine diets have shown dose-dependent reductions in the feed intake and body weight gain of pigs by dietary aflatoxin, DON, and ZEA [5,6,7]. The effectiveness of mycotoxin sequestering agents for aflatoxin has been well documented [13,19,20] Their effects on DON and ZEA, which are often co-contaminated in animal feeds, have been unknown or debatable [2,11]. Information on the mycotoxin sequestering efficacy of the yeast cell wall is very limited To bridge this gap, we determined the efficacy of 12 mycotoxin sequestering agents for aflatoxin B1 (AFB1), DON, and ZEA using an in vitro method that simulated the gastrointestinal tract of pigs
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call