Abstract
An experiment was conducted to determine the efficacy of mycotoxin sequestering agents for binding or degrading aflatoxin B1 (AFB1) and deoxynivalenol (DON) by an in vitro method. Ten toxin binder products including 5 bentonite clays (bentonite A, B, C, D, and E), 2 cellulose products (cellulose A and B), a yeast cell wall, an activated charcoal, and a mixture product containing minerals, microorganisms, and phytogenic substances were used in this experiment. An in vitro procedure was used to mimic the digestive process in pigs. The binding ability for AFB1 of the cellulose products was less compared with the values of other sequestering products (p < 0.05). The percent adsorption of AFB1 by bentonite clays, cellulose products, yeast cell wall product, activated charcoal product, and the mixture product were 92.5 (average of 5 bentonite products), −13.5 (average of 2 cellulose products), 92.7, 100.2, and 96.6, respectively. The respective values for DON were 3.24, 11.6, 22.9, 14.4, and 4.3. In conclusion, most toxin sequestering agents used in the present study had potential to bind AFB1 rather than DON based on the in vitro study which simulated the pH condition of the gastrointestinal tract of pigs.
Highlights
Dietary mycotoxins have been shown to cause detrimental effects in swine health and production
Sequestering agents Ten toxin binder products including 5 bentonite clays, 2 cellulose products, a yeast cell wall product, an activated charcoal product, and a mixture product consisted of minerals, microorganism, and phytogenic substances were used in this experiment
The quantification ranges of enzyme-linked immunosorbent assay (ELISA) kit used for analysis on aflatoxin B1 (AFB1) and DON were from 2 to 50 and 250 to 5,000 ng/mL, respectively
Summary
Dietary mycotoxins have been shown to cause detrimental effects in swine health and production. The objective of this experiment was to determine the binding efficacy of various sequestering agents to mycotoxins by an in vitro method which mimicked the gastrointestinal condition of pigs.
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