Abstract
The addition of erythromycin induced a marked stimulation of the synthesis of N-acetylphenylalanyl-puromycin by the Escherichia coli ribosome; this effect was noticed in media of such low K + or NH + 4 concentrations that the puromycin reaction was otherwise hardly observed. The maximum stimulation of the reaction was observed at an erythromycin concentration in which an equimolar amount of the antibiotic was bound to the ribosomes in the system. These results may indicate that the binding of erythromycin induces an alteration of the conformation of the E. coli ribosome and a consequent change in the activity of the ribosome.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
