Abstract
The addition of erythromycin induced a marked stimulation of the synthesis of N-acetylphenylalanyl-puromycin by the Escherichia coli ribosome; this effect was noticed in media of such low K + or NH + 4 concentrations that the puromycin reaction was otherwise hardly observed. The maximum stimulation of the reaction was observed at an erythromycin concentration in which an equimolar amount of the antibiotic was bound to the ribosomes in the system. These results may indicate that the binding of erythromycin induces an alteration of the conformation of the E. coli ribosome and a consequent change in the activity of the ribosome.
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