Abstract
Poly(5-methoxycytidylic acid) [poly(mo 5C)] has been prepared by polymerization of 5-methoxycytidine diphosphate with polynucleotide phosphorylase. The poly(mo 5C) was of high molecular weight and formed a 1 : 1 hybrid with poly(I). Although the T m of this hybrid is higher than that of poly(I) · poly(C) in 0.1 M salt, poly(I) · poly(mo 5C) is not an inducer of interferon.
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