Abstract
Nowadays, much attention is devoted to develop green, safe, and energy-efficient chemistry for drug synthesis with minimal impact on environment and health. Drugs are typically synthesized by chemical means using solvents and chemical reagents generating toxic wastes and by-products which pollute the environment. Therefore, pharmaceutical industries are gradually adopting environment-friendly green chemistry for manufacturing drugs. These efforts led to the development of novel aqueous-based chemistry with biocatalysts that reduce solvent and reagent consumption resulting in minimum impact on environment. Such chemistry has been successfully implemented to manufacture life-saving drugs. These include cholesterol-lowering statin drugs like lovastatin, simvastatin, atorvastatin, and rosuvastatin which inhibit HMG-Co-A reductase responsible for cholesterol synthesis in the liver. Increased LDL-cholesterol in blood is the key risk factor for cardiovascular disease as it leads to atherosclerotic plaque deposit inside blood vessels causing blockage. These can result in stroke causing death or lifetime disability. This chapter provides an overall review of industry progress and accomplishments in embracing green chemistry for commercial synthesis of statin drugs.
Published Version
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