Chapter 1 - Nanocatalyzed organic transformations for synthesis of drug-like small molecules with medicinally privileged heterocycles

Abstract

The present chapter includes recent developments in nanocatalyzed sustainable organic transformations, with a special emphasis on the use of nanostructured catalysts in the synthesis of structurally and functionally diversified drug-like molecules incorporating privileged heterocyclic heterocycles. Moreover, nanocatalyzed synthetic methods included in the present chapter are environmentally sustainable and will provide access to a diverse range of natural product mimetic scaffolds with the use of combinatorial chemistry using environmentally sustainable reaction conditions. The nanocatalyzed reactions will be significantly important for the design and synthesis of new pharmaceutical products. The present chapter includes systematic categorization and summarization with updated information relating to the uses of sustainable nanocatalyzed multicomponent reactions in the construction of structurally diverse molecules with medicinally privileged heterocycles. The reaction mechanisms involving catalytic facilitation and the interaction of nanostructured catalysts with the reacting molecules have also been presented. The present chapter will contribute considerably not only to chemical research, especially organic syntheses and catalyzes, but also to drug discovery research, including pharmaceutical and biomedical research, in exploring the future opportunity in drug synthesis.