Abstract
Tuberculosis is considered one of the infectious diseases worldwide that pose a threat to global health. So, it is the need of the hour to design newer antitubercular drugs of diverse structural classes to meet the challenges that occur due to multidrug-resistant strains. The resistance is increasing day by day for the commonly used antitubercular drugs. Therefore, the long-term treatment of the drug is required to prevent further microbial infection. However, it results in drug resistance with a high probability of the reappearance of disease in immunocompromised patients. Currently, several antitubercular drugs with diverse molecular structures are available that exhibit suitable antitubercular activity against drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis. By using microwave radiation, organic synthesis can be performed efficiently and with better selectivity under simple reaction conditions as compared to homogeneous reactions. Microwave-accelerated organic synthesis (MAOS) is an effective approach to accelerate the reaction rate with an increase in product yield and selectivity toward various organic syntheses. In the current study, several lead compounds synthesized through the MWI method with antitubercular properties are described.
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