Abstract
This chapter focuses on the membrane transport proteins that are the members of the 14-helix H+/multidrug antiporter family. Members of the family mediate resistance to one or more structurally dissimilar antibiotics, antiseptics, and disinfectants. They are predicted to form 14 membrane-spanning helices by the hydropathy of their amino acid sequences and the activity of reporter gene fusions. The chapter discusses the nomenclature, biological sources, substrates, phylogenetic trees, topology plot, physical and genetic characteristics, conserved motifs, multiple amino acid sequence alignments, and database accession numbers for members of the 14-helix H+/multidrug antiporter family. Statistical analysis of multiple amino acid sequence comparisons places the 14-helix H+/multidrug antiporter family in the uniporter–symporter–antiporter (USA) superfamily, also known as the major facilitator superfamily (MFS).
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