Abstract
This chapter focuses on the membrane transport proteins that are the members of the sugar phosphate transporter family. Members of the family mediate uptake of structurally dissimilar phosphoesters and dicarboxylates—including hexose phosphates, glycerol-3-phosphate, hexuronates, and phthalates—by an exchange in which the accumulation of a substrate phosphate is coupled to the electroneutral release of inorganic phosphate or organophosphate. Members of the family are found in both gram-negative and gram-positive bacteria. They are predicted to contain 12 membrane-spanning helices by the hydropathy of their amino acid sequences and activities of reporter gene fusion. The chapter discusses the nomenclature, biological sources, substrates, phylogenetic trees, topology plot, physical and genetic characteristics, conserved motifs, multiple amino acid sequence alignments, and database accession numbers for members of the sugar phosphate transporter family. Statistical analysis of multiple amino acid sequence comparisons suggests that the sugar phosphate transporter family may be distantly related to the uniporter–symporter–antiporter transporter superfamily, also known as the major facilitator superfamily (MFS).
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