Abstract
Nuclear magnetic resonance (NMR) spectroscopy is a noninvasive and nondestructive technique that enables the detection and identification, in vivo and in vitro , of a variety of chemical species in a range of biological systems. High-resolution NMR is used in chemical research. NMR spectroscopy is relatively insensitive compared to other analytical techniques; however, it has the advantage of not requiring precise selection of analytical conditions to obtain qualitative and quantitative information from endogenous metabolites and xenobiotics. NMR spectroscopy can give rise to information regarding molecular interaction and mobility in complex systems, such as intact organs, isolated cells, and body fluids. This type of information is not easily accessible by other techniques. This chapter discusses NMR studies of body fluids and tissue extracts. The information available from an NMR study of body fluids and tissue extracts depends on the choice of pulse sequences and nuclei studied. NMR spectroscopy allows the study of macromolecules, including lipoproteins and proteins, and their interaction with low-molecular-weight metabolites and metal ions in intact body fluids.
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