Abstract
Publisher Summary Magnetic resonance images represent a spatial mapping of the nuclear magnetic resonance (NMR) characteristics of NMR-sensitive nuclei in a variety of materials. The majority of clinical magnetic resonance imaging (MRI) maps the water distribution in the tissue because the hydrogen nucleus in water is the most abundant in most biological materials. Tissues with differing spin densities and/or relaxation times may be distinguished on appropriately weighted images. It is this ability to distinguish between tissues with differing spin densities and relaxation times that forms the bulk of most clinical MRI studies. These images are used in a qualitative radiological fashion and have great clinical application. It was hoped that the quantitative measurement of the relaxation times would improve the specificity and diagnostic utility of MRI. However, this has not been the case for a variety of reasons. There is a large overlap in the relaxation times measured from normal and pathological tissues.
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