Abstract
This chapter discusses microcirculation and perfusion. Qualitative and quantitative evaluation of local perfusion is of interest in clinical and research applications. Most clinical images of perfusion have been obtained from nuclear medicine techniques, using radioactive tracers. Pathologists and radiologists are interested in tissue vascularity to stage tumors or to detect tumor recurrences. For these, perfusion imaging is a useful guide that helps determine sites of biopsy. Techniques have been developed that allow magnetic resonance imaging (MRI) to image quantities related to perfusion and to show subtle variations in perfusion associated with physiological or disease states. MRI has been proposed as a perfusion imaging modality because of several potential advantages. Compared to nuclear medicine approaches or to contrast-enhanced computed tomography, MRI offers a safer approach because no ionizing radiation is involved. The use of external tracers or contrast agents may not even be required in some instances. MRI provides images with great spatial and temporal resolution.
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