Abstract
The biological activity of β-glucan depends on several factors: polysaccharide water solubility, its molecular mass, type and configuration of glycoside bonds between residual monosaccharides, and macromolecular branching and conformations.The article shows that structure of the baker's yeast (Saccharomyces cerevisiae) glucan, isolated with peroxide method, contains sections with varying order strength. Hydrogen peroxide (H2O2) yeast treatment is supplemented by the destruction of amorphous formations and increase of glucan preparations crystallinity degree in 2.6...3.3 times compared to the reference specimen. It has been shown that water-soluble glucan has more ordered supramolecular structure (crystallinity index is 4.06) than the original insoluble glucan (crystallinity index is 2.55). The water-soluble glucan preparation obtained by partial enzimatic degradation of structural β-glucan contains molecular formations in the form of triple helices.Animal experiments showed the effectiveness of obtained β-glucan preparations as immunomodulators. The aggregate research findings of preparation supramolecular structure and its medical and biological assessment would be an argument, confirming the relation of β-glucan’s biological action to triple helix in its structure.
Highlights
The choice of cultures perspective for usage in production of fermented milk products for people with cardiovascular diseases has been proved
Taking into consideration the statistic data from the state registry of food products of special diet, functional food products and dietry supplement of Ministry of health service of Ukraine 2010-2014 and analysis of literary and patent sources – the research shows the perspectives of development for starter composition basing on pure cultures Lactobacillus plantarum and mixed cultures Lactococcus lactis subsp. lactis, Lactococcus lactis subsp. cremoris, that can become a basis for starter complex producing fermented milk products for people with cardiovascular diseases
The article shows that structure of the baker's yeast (Saccharomyces cerevisiae) glucan, isolated with peroxide method, contains sections with varying order strength
Summary
Последнее десятилетие ознаменовалось бурным развитием химии и технологии β-глюканов. Бетаглюканы – биополимеры, обладающие широким спектром биологической активности. Особый интерес в этом отношении представляют β-(1→3)/(1→6)-Dглюканы [1], основными источниками которых являются некоторые штаммы дрожжей и ряд грибов. Что биологическая активность βглюкана зависит от ряда факторов: типа и конфигурации связей между остатками моносахаридов, разветвленности и конформации макромолекулы, растворимости в воде, молекулярной массы [2]. Перспективным источником этого полисахарида являются пекарские дрожжи. Он не растворяется в воде, что уменьшает эффективность его использования как биологически активного пищевого ингредиента, не давая возможность реализовать присущий ему потенциал. Характеристика препаратов β-глюкана, как правило, заключается в определении его молекулярного строения, молекулярной массы, ряда физикохимических показателей и биологических эффектов. В то же время, выяснение особенностей супрамолекулярного строения является одним из необходимых условий, позволяющих выявлять закономерности взаимосвязи между биологическими эффектами βглюкана и его структурной организацией
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
