Abstract
The literature review considers the role of ectopic adipose tissue in the formation of cardiometabolic risks. The aim of this publication is to systematize current data on the incidence and clinical characteristics of obesity associated with excessive accumulation of ectopic adipose tissue. Materials and methods . We carried out the search in PubMed electronic scientific databases and the database of the Russian scientific electronic library eLibrary for keywords and phrases: ectopic adipose tissue, perivascular adipose tissue, paranephral adipose tissue, epicardial adipose tissue, cardiovascular risk. Results . We carried out a comprehensive analysis of modern scientific data on the mechanisms of formation and the pathophysiological role of ectopic fat depots in the development of cardiovascular and metabolic diseases. We paid particular attention to various localizations of ectopic fat (epicardial, perivascular, visceral), their endocrine activity and the effect on metabolic processes. We considered mechanisms by which ectopic adipose tissue contributes to the development of insulin resistance, systemic inflammation, atherosclerosis and other pathological conditions. Conclusion . Excess ectopic adipose tissue deposits are a modifiable risk factor that should be considered as a therapeutic target for the development and application of novel targeted strategies in the diagnosis and treatment of obese patients.
Published Version
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