The purpose of this study was to examine the effect of different cleaning methods and resin cements on the shear bond strength (SBS) of contaminated zirconia. A total of 92 disc-shaped zirconia specimens were contaminated with different procedures. Then, the specimens were grouped according to cleaning methods and resin cements: no cleaning + Variolink Esthetic DC (CNV ), no cleaning + Panavia V5 (CNP ), sandblasted + Variolink Esthetic DC (SBV ), sandblasted + Panavia V5 (SBP ), Ivoclean + Variolink Esthetic DC (ICV ), Ivoclean + Panavia V5 (ICP ), Katana Cleaner + Variolink Esthetic DC (KCV ), and Katana Cleaner + Panavia V5 (KCP ). Following an aging protocol in a 37°C for 1week, SBS analysis was performed with a universal test machine. For the surface topography and elemental analysis, scanning electron microscopy and energy-dispersive X-ray spectroscopy (EDS) were used. Significance was evaluated as p< .05 and p< .01. The highest SBS results were found in the SBP group, showing a statistically significant difference from all other groups (p <.05). For the same cleaning method, Panavia V5 showed statistically significantly higher SBS values than Variolink Esthetic DC (p< .01), except the CNP -CNV (p= .880) and KCP -KCV (p= .082) groups. The most detected surface elements by EDS were Zr, O, C, and N, respectively. The contaminated zirconia surfaces must be cleaned for successful adhesion. The use of phosphate-containing adhesives in combination with sandblasting will increase the adhesion strength, and universal cleaning agents can be a good alternative to sandblasting.