Zinc Salts Research Articles

Effective Regulation of ZnO Surface Facets for Enhanced Photoluminescence Properties Assisted by Zinc Quaternary Ammonium Salts.

Novel ZnO twined-mushroom structures highly exposed in (001̅) planes were fabricated via a facile solvothermal synthesis with assistance of a zinc quaternary ammonium salt in the methanol–water solvent to show enhanced photoluminescence properties. A series of ZnO morphologies regulated with different surface facets were obtained in both MeOH–H2O and EtOH MeOH–H2O solvents respectively, tuning the proportion of alcohol. The self-aggregation mechanism was proposed based on the time-controlled experiment to evaluate the formation of twined-mushroom structures. The selective adsorptions of anions from zinc salt precursors determine the shape of subunits and direct the subunits, which act as building blocks to form the order aggregations.

Wilson's disease: Revisiting an old friend.

Wilson's disease (WD) is a rare condition caused by copper accumulation primarily in the liver and secondly in other organs, such as the central nervous system. It is a hereditary autosomal recessive disease caused by a deficiency in the ATP7B transporter. This protein facilitates the incorporation of copper into ceruloplasmin. More than 800 mutations associated with WD have been described. The onset of the disease frequently includes manifestations related to the liver (as chronic liver disease or acute liver failure) and neurological symptoms, although it can sometimes be asymptomatic. Despite it being more frequent in young people, WD has been described in all life stages. Due to its fatal prognosis, WD should be suspected in all patients with unexplained biochemical liver abnormalities or neurological or psychiatric symptoms. The diagnosis is established with a combination of clinical signs and tests, including the measurement of ceruloplasmin, urinary copper excretion, copper quantification in liver biopsy, or genetic assessment. The pharmacological therapies include chelating drugs, such as D-penicillamine or trientine, and zinc salts, which are able to change the natural history of the disease, increasing the survival of these patients. In some cases of end-stage liver disease or acute liver failure, liver transplantation must be an option to increase survival. In this narrative review, we offer an overview of WD, focusing on the importance of clinical suspicion, the correct diagnosis, and treatment.

High electrochemical and mechanical performance of zinc conducting-based gel polymer electrolytes

Zinc ionic conducting-based gel polymer electrolytes (GPEs) were fabricated from carboxymethyl cellulose (CMC) and three different zinc salts in a mass ratio ranging within 0–30 wt%. The effects of zinc salt and loading level on the structure, thermal, mechanical, mechanical stability, and morphological properties, as well as electrochemical properties of the GPEs films, were symmetrically investigated. The mechanical properties and mechanical stability of CMC were improved with the addition of zinc acetate, zinc sulphate, and zinc triflate, approaching the minimum requirement of a solid state membrane for battery. The maximum ionic conductivity of 2.10 mS cm−1 was achieved with the addition of 15 wt% zinc acetate (ZnA), GPEA15. The supported parameters, indicating the presence of the amorphous region that likely supported Zn2+ movement in the CMC chains, were clearly revealed with the increase in the number of mobile Zn2+ carriers in FT-IR spectra and the magnitude of ionic transference number, the decrease of the enthalpy of fusion in DSC thermogram, and the shifting to lower intensity of 2θ in XRD pattern. The developed CMC/ZnA complex-based GPEs are very promising for their high ionic conductivity as well as good mechanical properties and the ability for long-term utilization in a zinc ion battery.

Determination of Zinc Content in Commercial Toothpaste Samples in Nigeria by Atomic Absorption Spectrophotometric Method

Zinc as its citrate or sulphate salt is added to some toothpaste as a bactericide to reduce the presence of bacteria in the mouth. These bacteria can form plaque or produce acids which cause dental decay and halitosis. Zinc salt is added at amounts which are enough to show activity against oral bacteria without causing toxicity to the user. Five commercial samples of different brands of toothpaste (TP-A, TP-B, TP-C, TP-D and TP-E) were purchased from different pharmacy stores in Ogige and Eko markets, Nigeria and analysed for the presence of zinc using atomic absorption spectrophotometric method. The samples were digested with deionized water and HNO3, centrifuged and filtered. The absorbance of the supernatants obtained was read with a spectrophotometer. Calibration curves for zinc sulphate and zinc citrate were obtained with regression (R2) values of 0.9992 and 0.9973, respectively. The equation obtained from the curves used in determining the content of zinc in the samples. The zinc content (% w/w) of samples was determined to be 0.8467%, 0.8127%, 0.0119%, 0.0188% and 0.0305%, respectively. These values were well below the maximum permissible level of zinc in toothpaste samples but were within the upper limit for daily zinc intake.

Advances in Understanding of the Application of Unit Operations in Metallurgy of Rare Earth Elements

Unit operations (UO) are mostly used in non-ferrous extractive metallurgy (NFEM) and usually separated into three categories: (1) hydrometallurgy (leaching under atmospheric and high pressure conditions, mixing of solution with gas and mechanical parts, neutralization of solution, precipitation and cementation of metals from solution aiming purification, and compound productions during crystallization), (2) pyrometallurgy (roasting, smelting, refining), and (3) electrometallurgy (aqueous electrolysis and molten salt electrolysis). The high demand for critical metals, such as rare earth elements (REE), indium, scandium, and gallium raises the need for an advance in understanding of the UO in NFEM. The aimed metal is first transferred from ores and concentrates to a solution using a selective dissolution (leaching or dry digestion) under an atmospheric pressure below 1 bar at 100 °C in an agitating glass reactor and under a high pressure (40–50 bar) at high temperatures (below 270 °C) in an autoclave and tubular reactor. The purification of the obtained solution was performed using neutralization agents such as sodium hydroxide and calcium carbonate or more selective precipitation agents such as sodium carbonate and oxalic acid. The separation of metals is possible using liquid (water solution)/liquid (organic phase) extraction (solvent extraction (SX) in mixer-settler) and solid-liquid filtration in chamber filter-press under pressure until 5 bar. Crystallization is the process by which a metallic compound is converted from a liquid into a crystalline state via a supersaturated solution. The final step is metal production using different methods (aqueous electrolysis for basic metals such as copper, zinc, silver, and molten salt electrolysis for REE and aluminum). Advanced processes, such as ultrasonic spray pyrolysis, microwave assisted leaching, and can be combined with reduction processes in order to produce metallic powders. Some preparation for the leaching process is performed via a roasting process in a rotary furnace, where the sulfidic ore was first oxidized in an oxidic form which is a suitable for the metal transfer to water solution. UO in extractive metallurgy of REE can be successfully used not only for the metal wining from primary materials, but also for its recovery from secondary materials.

Confinement of Zinc Salt in Ultrathin Heterogeneous Film to Stabilize Zinc Metal Anode.

Aqueous zinc metal batteries (AZMBs) have drawn great attention due to the high theoretical capacity, low redox potential, and abundance reserves. However, the practical application of rechargeable AZMBs are hindered by the poor reversibility of Zn metal anode, owing to easy dendrite growth and serious side reactions. Herein, the preparation of heterogeneous interfacial film with highly dispersed and confined zinc salt in a 2D channel by coassembling polyamide 6, zinc trifluoromethanesulfonate, and layered double hydroxides, which significantly suppresses the dendrite formation, H2 evolution reaction as well as O2 corrosion is reported. The as-developed Zn anodes exhibit a long cycling life up to 1450 h with low reversible deposition potential. Moreover, the assembled Zn||Mn battery delivers a high initial capacity of 321 mAh g-1 and a low capacity decay of ≈0.05% per cycle after 590 cycles, which is promising for high-performance AZMBs. A fluorescent film to realize the in situ observation of the Zn anode during cycling, which provides a new chance for visual observation of the working state of the Zn interface, is also assembled.

Spin glass behavior and oxidative catalytic property of Zn2MnO4 from a metathesis driven metastable precursor

The reaction of chloride salts of zinc and manganese with NaOH yielded a cubic spinel structured metastable precursor at room temperature, driven mainly by the salt elimination process's energetics. While classical drying processes failed to produce the monophasic oxide, recrystallization under the hydrothermal conditions yielded Zn2MnO4 in nano dimensions. The sample consisted of crystallites with an average 6 nm size and had a lattice dimension of 8.396 (13) Å. The selected area electron diffraction pattern reiterated the occurrence of cubic inverse spinel. The presence of fingerprint (A1g and F2g) modes of an inverse spinel at 663 and 561 cm−1 in the Raman spectrum further supported our finding. The TEM-EDS analysis confirmed the ratio of Zn: Mn as 1.95:1. The sample showed an optical bandgap of 2.54 eV. X-ray photoelectron spectral analysis established the existence of manganese in the IV oxidation state. The presence of Mn (IV) with small amounts of Mn (III) (up to 20%) was confirmed from the electron paramagnetic spectra recorded at room temperature and 77 K. An average oxidation state of 3.85 was deduced from the chemical redox titration experiments. The pseudocapacitive behavior of the sample was evident in cyclic voltammetric experiments. The sample exhibited paramagnetic behavior at 298 K within the applied magnetic field of ±50 kOe. In the temperature-dependent measurements, the zero-field and field cooled data points of Zn2MnO4 diverged at 13 K, suggesting a spin-glass behavior. An effective magnetic moment of 4.31 BM was deduced for the sample. The inverse spinel effectively catalyzed the oxidation of phenol. It facilitated nearly 100% degradation of bisphenol-A to salicylaldehyde and phenylethyl alcohol (as major products) in the presence of H2O2 and at a pH of 9.

Translocation of chromatin proteins to nucleoli-The influence of protein dynamics on post-fixation localization.

It is expected that the subnuclear localization of a protein in a fixed cell, detected by microscopy, reflects its position in the living cell. We demonstrate, however, that some dynamic nuclear proteins can change their localization upon fixation by either crosslinking or non‐crosslinking methods. We examined the subnuclear localization of the chromatin architectural protein HMGB1, linker histone H1, and core histone H2B in cells fixed by formaldehyde, glutaraldehyde, glyoxal, ethanol, or zinc salts. We demonstrate that some dynamic, weakly binding nuclear proteins, like HMGB1 and H1, may not only be unexpectedly lost from their original binding sites during the fixation process, but they can also diffuse through the nucleus and eventually bind in nucleoli. Such translocation to nucleoli does not occur in the case of core histone H2B, which is more stably bound to DNA and other histones. We suggest that the diminished binding of some dynamic proteins to DNA during fixation, and their subsequent translocation to nucleoli, is induced by changes of DNA structure, arising from interaction with a fixative. Detachment of dynamic proteins from chromatin can also be induced in cells already fixed by non‐crosslinking methods when DNA structure is distorted by intercalating molecules. The proteins translocated during fixation from chromatin to nucleoli bind there to RNA‐containing structures.

Counterion-Induced Tailoring of Energy Transfer in Hydrothermally Grown Nanostructured ZnO for Photocatalysis

Morphological tailoring of zinc oxide (ZnO) nanostructures, viz., nanogranules, hexagonal pillars, and nanorods, has been demonstrated using the hydrothermal method by varying the precursor salts of zinc. Counterions of precursor salts, such as zinc chloride, zinc acetate, and zinc nitrate, are found to influence nucleation and growth of the nanostructures. Determination of crystalline and morphological properties of different nanostructures has been carried out by using X-ray diffraction and field emission scanning electron microscopy. The X-ray photoelectron spectroscopy technique is used for the investigation in a comparative surface study of ZnO nanostructures, and possible growth mechanisms of different nanostructures have been described. Bandgap and Urbach energies of the materials are also affected by the counterions of the precursor salts. Fourier transform infrared spectra of ZnO nanostructures show shifting of band positions of the functional group caused by variation of the precursor salt. Features of photoluminescence emission spectra of the ZnO nanostructures are ascribed to the association of different defect states due to the change of counterions. Moreover, the variation of precursor salts also influences the efficiency of Förster resonance energy transfer between the donor (ZnO) and acceptor (MB dye). ZnO with different nanostructures exhibits commendable photocatalysis degradation efficiency toward methylene blue dye (MB dye). Thus, the emission property and photocatalytic property of the ZnO nanostructures can be tuned by the variation of precursor salts. In this work, the role of counterions is established as a tool to control the ZnO nanostructures along with achieving control over the defect state emissions. This work not only establishes a relation between defects and photocatalysis, but also it deals with the variation of oxygen defects induced by the counterions of the zinc precursor salts.

Passivating Quantum Dot Carrier Transport Layer with Metal Salts.

Quantum dots (QDs) have a wide range of applications in the field of optoelectronics. They have been playing multiple roles within the configuration of a device, by serving as the building blocks for both the active layer and the carrier transport layer. While the performance of various optoelectronic devices has been steadily improving via developments in passivating the QD active layer, the possible improvement via passivation of the QD-based carrier transport layer has been largely overlooked. Here, with lead sulfide QD photovoltaics as the platform of study, we demonstrate that the device performance can be significantly improved by passivating the QD hole transport layer (HTL) with zinc salt post-treatments. The power conversion efficiency is improved from 8.7% of the reference device to 10.2% and 9.5% for devices with zinc acetate (ZnAc)- and zinc iodide (ZnI2)-treated HTLs, respectively. Transient absorption spectroscopy confirms that both treatments effectively reduce band-tail states and increase carrier lifetime of the HTLs. Further elemental analysis shows that ZnAc provides a higher amount of Zn2+ for passivation while maintaining the function of HTL by allowing essential p-doping oxidation. In contrast, the additional I- passivation from ZnI2 inhibits p-doping oxidation and limits the function of HTL. This work demonstrates the potential of improving device performance by passivating the QD-based HTLs, and the method developed is likely applicable to other optoelectronic devices.

Pd-promoting reduction of zinc salt to PdZn alloy catalyst for the hydrogenation of nitrothioanisole

Catalytic hydrogenation of sulfur-containing substrates is an important and challenging reaction in the chemical industry. In this work, active carbon supported PdZn alloy catalyst was prepared by self-reduction method using zinc acetate as precursor without H2 atmosphere. During the process of self-reduction, Zn2+ was firstly reduced to Zn0 at 300 °C by active carbon and reducing gas from the decompose of acetate under the promotion of metal Pd, and Zn0 further reacted with metal Pd to form PdZn alloy phase at 500 °C. These PdZn/AC-X catalysts showed the higher conversion and stability for the hydrogenation of 4-nitrothioanisole than the Pd/AC-600 catalyst. The excellent catalytic performance of PdZn/AC-600 catalyst can be attributed to formation of PdZn alloy, in which electron-rich Pd atoms weaken the binding ability between Pd and S and enhance the sulfur-resistance of catalyst. On the other hand, H2-TPR and DFT theory calculation further indicated that the PdZn alloy phase weakens the adsorption capacity of S. Compared with the Pd/AC-600 catalyst, the PdZn alloy phase in PdZn/AC-600 catalyst has not changed and only a small amount of sulfur-containing substrates deposited on the catalyst surface after three cycles. PdZn/AC-600 catalyst exhibited improved stability in the hydrogenation of 4-nitrothioanisole and can be used three cycles with little decrease in activity.

Amino-functionalized Ti3C2Tx loading ZIF-8 nanocontainer@benzotriazole as multifunctional composite filler towards self-healing epoxy coating

It is difficult for Ti3C2Tx-containing epoxy coatings to prevent electrochemical corrosion at the metal/coating interface after long-term exposure to corrosive environments. Thus, endowing Ti3C2Tx-containing epoxy coatings with self-healing function and good wear resistance is very significant. Here, a novel self-healing epoxy coating (f-Ti3C2Tx-ZB@EP) is designed via incorporating with amino-functionalized Ti3C2Tx loading 2-methylimidazole zinc salt (ZIF-8) nanocontainer@benzotriazole (f-Ti3C2Tx-ZB) multifunctional composite filler, and its anti-corrosion and tribological properties are evaluated in detail. The as-prepared f-Ti3C2Tx-ZB@EP shows an order of magnitude enhancement in coating resistance (Rc) and achieves self-healing function under severe environment, which are attributed to the synergistic effect of passive and active protection. Specially, the change of pH value caused by electrochemical corrosion could induce the nanocontainer to release BTA, thereby forming corrosion inhibition films on the coating/metal interface. Besides, the wear rate of f-Ti3C2Tx-ZB@EP is decreased by one order of magnitude because of the lubrication effect of Ti3C2Tx at the friction interface and the high resistance to plastic deformation of epoxy composite coating. Therefore, f-Ti3C2Tx-ZB@EP with better self-healing, anti-corrosion and tribological properties is equipped with long-term metal protection ability and enlightens a thought-provoking idea for corrosion and wear resistance.

STUDY OF THE PROCESS OF PYROLYSIS OF CALCIUM ADIPATE AT DIFFERENT TEMPERATURES

This article discusses a method for producing cyclopentanone and cyclopentene on the basis of wateracid effluents from caprolactam production during pyrolysis of the calcium salt of adipic acid at different temperatures. The compound of the obtained liquid product has proved by the method of chromatographic analysis and the dependence of the yields of cyclopentanone on the process temperature has investigated. A qualitative analysis of calcium adipate by X-ray fluorescence spectrometry has carried out, and the possibility of using zinc salts as process catalysts has studied.

Photocatalytic degradation of selected pharmaceuticals using green fabricated zinc oxide nanoparticles

Heterogeneous photocatalysis is one of the popular alternative treatment methods for wastewater. It utilizes semiconductor material as the catalyst and metal oxide such as zinc oxide nanoparticles (ZnO NPs), emerged as the commonly used catalyst. In this study, a series of biogenic ZnO NPs was fabricated through precipitation method with pullulan as the biomaterial. The amount of zinc salt in the presence of pullulan was varied to study its impact on the generated ZnO NPs. The results showed that without pullulan, the average particle size of ZnO NPs obtained was 110.86 nm. With 0.84 M zinc salt in 50 g/L of pullulan, the ZnO NPs average particle size significantly reduced to 58.13 nm. The surface area of all synthesized ZnO NPs ranging from 14.84 to 19.99 m2 g−1. The photocatalytic activities of all synthesized ZnO NPs were evaluated through the photodegradation of two drugs, amoxicillin (AMX) and paracetamol (PCT). Through the comparison of drugs’ photodegradation with all synthesized ZnO NPs, ZnO NPs produced with 0.67 M zinc salt in 50 g/L of pullulan showed the highest degradation percentage of 85.7% and 96.8% for AMX and PCT respectively. The best photodegradation conditions for the drugs were 30 ppm drugs concentration, pH 9 (for AMX) and pH 5 (for PCT) and 50 mg catalyst dosage. Based on these results, biogenic ZnO NPs has high potential to be used in the treatment of pharmaceutical wastewater.

Pediatric Wilson's Disease: Phenotypic, Genetic Characterization and Outcome of 182 Children in France.

To describe a cohort of Wilson disease (WD) pediatric cases, and to point out the diagnostic particularities of this age group and the long-term outcome. Clinical data of 182 pediatric patients included in the French WD national registry from 01/03/1995 to 01/06/2019 were gathered. Diagnosis of WD was made at a mean age of 10.7 ± 4.2 years (range 1-18 years). At diagnosis, 154 patients (84.6%) had hepatic manifestations, 19 (10.4%) had neurological manifestations, and 9 patients (4.9%) were asymptomatic. The p.His1069Gln mutation was the most frequently encountered (14% of patients).Neurological patients were diagnosed at least 1 year after they presented their first symptoms. At diagnosis, the median urinary copper excretion (UCE) was 4.2 μmol/24 hours (0.2-253). The first-line treatment was d-penicillamine (DP) for 131 (72%) patients, zinc salts for 24 (13%) patients, and Trientine for 17 (9%) patients. Liver transplantation was performed in 39 (21.4%) patients, for hepatic indications in 33 of 39 patients or for neurological deterioration in 6 of 39 patients, mean Unified Wilson's Disease Rating Scale of the latter went from 90 ± 23.1 before liver transplantation (LT) to 26.8 ± 14.1 (P < 0.01) after a mean follow-up of 4.3 ± 2.5 years. Overall survival rate at 20 years of follow-up was 98%, patient and transplant-free combined survival was 84% at 20 years. Diagnosis of WD can be challenging in children, particularly at the early stages of liver disease and in case of neurological presentation; hence the support of clinical scores and genetic testing is essential. Diagnosis at early stages and proper treatment ensure excellent outcomes, subject to good long-term treatment compliance. LT is a valid option for end-stage liver disease not responding to treatment and can be discussed for selected cases of neurological deterioration.

ОЦЕНКА МЯСНОЙ ПРОДУКТИВНОСТИ И КАЧЕСТВА МЯСА ТЕЛЯТ, ПОЛУЧАВШИХ КОРМОВЫЕ ДОБАВКИ НА ОСНОВЕ ХЕЛАТНЫХ КОМПЛЕКСНЫХ СОЕДИНЕНИЙ И НЕОРГАНИЧЕСКИХ СОЛЕЙ МЕТАЛЛОВ-МИКРОЭЛЕМЕНТОВ

The influence of the use of feed additives used in the cultivation of calves on the quality of their meat and meat productivity was studied. Calves were given two types of liquid feed additives: 1) freshly prepared solutions of inorganic salts of copper, zinc, cobalt, iron and manganese; 2) solu-tions of chelated complex compounds of these trace elements. A fractional - periodic scheme of their administration was used, which minimizes the effect of physiological antagonism of trace ele-ments. It was shown that the meat of animals treated with complex compounds had a higher content of trace elements and better indicators of fat content and protein.

Foliar Application of Zn Agrichemicals Affects the Bioavailability of Arsenic, Cadmium and Micronutrients to Rice (Oryza sativa L.) in Flooded Paddy Soil

Zinc (Zn) is a key micronutrient affecting bio-functions of crops. Impacts of foliar application of three forms of Zn-containing agrichemicals on the physiology of rice seedlings and their uptake of heavy metal(loid)s and micronutrients from fully flooded paddy soils were investigated in a greenhouse study. Rice seedlings 45 days after germination were randomly exposed to an equivalent amount of 100 mg L−1 of zinc oxide nanoparticles (ZnONPs), zinc oxide bulk particles (ZnOBPs), and zinc salts (Zn2+) through foliar exposure. At termination, rice seedlings were divided into roots and shoots and the concerned metal contents in plant tissues were determined with an inductively coupled plasma mass spectrometry (ICP-MS). Our results demonstrated that all Zn agrichemicals displayed a similar effect on plant growth, but ZnONPs led to the greatest root exudate excretion and greatest inhibition in arsenic (As) uptake. Foliar application of ZnONPs resulted in 28% less As in rice shoots while Zn2+ only caused a 15% decrease in As accumulation in the same tissues. ZnOBPs had minimal impact on As concentration in rice shoots. ZnONPs also promoted iron (Fe) and copper (Cu) uptake in rice shoots, both of which are essential micronutrients for humans. The results suggest that foliar application of ZnONPs resulted in more favorable outcomes for plant growth and food safety than other two types of Zn. Overall, our results showed that application of nanoagrichemicals have important food safety and nutrition implications in addition to their agronomical roles and ZnONPs could be potentially used to alleviate As uptake and fortify Zn and other essential micronutrients in rice grains.

Hypothesis of zinc ascorbate as best zinc ionophore for raising antiviral resistance against Covid-19.

Zinc Ascorbate could prevent and treat Covid-19 by raising anti-viral resistance to SARS-CoV-2 virus via increase of intracellular zinc concentration as a zinc ionophore more than other salts of zinc or zinc with vitamin C. Tests in-vitro and clinical trials for Covid-19 prevention and treatment with Zinc Ascorbate are strongly recommended and should start as soon as possible. Potential advantages of zinc ascorbate supplementation over vaccines and drugs are also discussed, with supplementation suggestions This article is protected by copyright. All rights reserved.

Maladie de Wilson

AbstractWilson’s disease is a autosomal recessive inherited disorder that causes progressive copper overload. The ATP7B gene carried on chromosome 13 encodes an intracellular copper transporter ATP7B protein that allows cellular excretion of excess copper. In Wilson’s disease, the functional deficiency of ATP7B causes a failure in the elimination of copper from the bile, which then accumulates in the liver and is then released in free form into the bloodstream. Wilson’s disease is therefore an initially hepatic disorder which can progress to multisystem involvement with an accumulation of copper in the brain, eye, kidney, etc. if it is not diagnosed early. The first symptoms are most often hepatic in children and neurological in adults. The diagnosis is made on a bundle of clinical, biological and radiological arguments. Interpretation of the cupric balance, typically associating a decrease in ceruloplasminemia and total cupremia with an increase in 24-hour urinary copper excretion, can be difficult, justifying the determination of the free or exchangeable copper. The ratio of exchangeable copper/total copper or REC (relative exchangeable copper) is an excellent diagnostic biomarker. Molecular biology can confirm the diagnosis in 98 % of cases. The treatments combine a copper low diet, copper chelators or zinc salts. Liver transplantation is the treatment for fulminant liver forms and decompensated cirrhosis. This rare genetic disease has a good prognosis if treatment is started early and continued all lifelong. It is therefore important to know the clinical manifestations of the disease and the diagnostic tests in order to evoke it quickly and to then ensure regular clinical and laboratory monitoring of patients.

Indium-Catalyzed C-F Bond Transformation through Oxymetalation/β-Fluorine Elimination to Access Fluorinated Isocoumarins.

Fluorinated heterocycles have attracted much attention in the pharmaceutical and agrochemical industries. Many strategies have already been developed to achieve the synthesis of fluorinated heterocycles. Formidable challenges remain, however, in the synthesis of fluorinated isocoumarin derivatives that are among the most alluring structural motifs. Herein, the indium-catalyzed C-F bond transformation of 2-(2,2-difluorovinyl) benzoates is reported, which are readily accessible compounds, to give a diverse array of fluorinated isocoumarins. The present reaction proceeds smoothly using inexpensive reagents: a catalytic amount of indium salt in the presence of zinc salt. A theoretical calculation of potential energy profiles showed that the reaction consists of oxymetalation with the elimination of alkyl halide and the β-fluorine elimination.