Zeolitic Imidazolate Framework Research Articles

A covalently integrated ZIF-8/polyamide acid mixed matrix membrane with superior gas separation performance

Zeolitic imidazolate framework-8 (ZIF-8) is a typical filler used to fabricate mixed matrix membranes (MMMs) on account of its attractive advantage of high selective permeability for gas separation. However, the performance is usually affected by filler aggregation due to strong interactions among fillers and weak interactions between the polymer and fillers, However, the performance is usually affected by filler aggregation due to strong interactions among fillers and weak interactions between the polymer and fillers, which will lead to a decrease of selectivity and the performance of gas separation will be strongly influenced. Herein, we modified ZIF-8 with 3-amino-1,2,4-triazole to obtain ZIF-8-NH2, Kapton polyamide acid was selected as the polymer matrix. Results showed that the ZIF-8-NH2/Kapton MMMs has a good compatibility interface between ZIF-8 and Kapton because of the covalent bridging, even the filler loading up to 45% (mass). The 45% (mass) of ZIF-8-NH2/Kapton membrane showed 297 Barrer (1 Barrer = 10−10 cm3 cm·cm−2·s–1·cmHg–1, 1 cmHg = 1333.22 Pa, standard temperature and pressure) of the permeability of H2 and 43.9 and 62.2 of selectivities for H2/N2 and for H2/CH4, respectively, which are beyond the upper limit of Robeson 2008.

Facile and controllable hybrid-nanoengineering of MWCNTs/Au@ZIF-8 and AuPt@CeO2 based sandwich electrochemical aptasensor for AFB1 determination in foods and herbs

Herein, a sandwich electrochemical sensing strategy for aflatoxin b1 (AFB1) detection based on hybrid-nanoengineering was presented. First, Au nanoparticle was doped into zeolitic imidazolate framework-8 (ZIF-8) to form Au@ZIF-8 by in-situ growth method, followed by multi-walled carbon nanotubes (MWCNTs) addition to synthesize MWCNTs/Au@ZIF-8 via self-assembly. The structural “confinement effect” of ZIF-8 afforded a microenvironment for Au nanoparticles and SMCNTs in a certain spatial region, giving MWCNTs/Au@ZIF-8 excellent electrochemical property as the substrate material. In addition, Au-Pt bimetallic nanoparticle, which exhibited excellent stability and catalytic activity was loaded on the hollow cerium oxide (CeO2) to form AuPt@CeO2 nanoparticle through one-step aqueous phase reduction. Owning to its high surface-to-volume ratio, satisfied electron transfer efficiency and biocompatibility, massive toluidine blue (TB) and AFB1 antibody (Ab) could be modified on the AuPt@CeO2 to form AuPt@CeO2-Ab-TB, which acted as signal tag for the ultrasensitive assay of AFB1. The proposed electrochemical sensing system exhibited wide detection range (2 × 10-5 − 20 ng/mL) and low detection limit (2.13 fg/mL), which has been successfully applied to AFB1 determination in four real samples. The hybrid nanoengineering presented in this work is an active attempt to prepare high-performance substrate material and signal tag, which provides a new insight for the development of highly sensitive and specific electrochemical sensing systems.

A large-area MOF-based membrane for challenging CO2 purification and ethanol/CO2/N2 ternary mixture separation

Bioethanol has garnered widespread attention as a potential substitute for traditional fossil fuels. Focusing on the treatment of bioethanol fermentation exhaust is crucial for optimizing bioethanol recovery and achieving carbon dioxide (CO2) purification. This study successfully achieved the large-scale synthesis of zeolitic imidazolate framework-8 (LSZIF-8), which was then incorporated into polydimethylsiloxane (PDMS) to fabricate large-area ZIF-8/PDMS/PVDF mixed matrix membranes (MMMs) for bioethanol recovery from fermentation exhaust via vapor permeation (VP) processes. The ZIF-8/PDMS/PVDF MMMs exhibited a 1.5-time increase in ethanol permeability and selectivity improved by 1.7 times compared to the PDMS/PVDF membrane. The mass transport behavior of ethanol and CO2 molecules within the membrane, as well as examining the interactions between different components was systematically explored. It delves into the disparities in separation performance between PDMS/PVDF membrane and ZIF-8/PDMS/PVDF MMMs with nitrogen (N2), water vapor as the third component. Notably, high-quality LSZIF-8 crystals serves as a crucial source of raw materials for the continuous preparation of high-performance MMMs, addressing the limitation of traditional nanoparticle fillers in terms of scalability for production. This study paving new avenues for purifying fermentation exhaust and recovering bioethanol, while simultaneously present significant potential for industrial applications.

Amino functionalized zeolitic imidazolate framework-8 coated cellulose aerogel for enhanced air purification

Human activities generate large quantities of air pollutants, and particulate matter (PM) in the air poses a serious threat to public health. Nanofiber filters with surface-loaded metal–organic frameworks (MOFs) are promising materials for the capture of PM. Herein, this work creatively fabricated an air filter by anchoring amino-functionalized ZIF-8 on the surface of cellulose aerogel (NZCA) by in situ growth approach. The excellent compatibility between ZIF and cellulose was demonstrated by XRD, FT-IR, SEM and XPS characterization techniques. The functionalized ligand introduces –NH2, and the polar –NH2 group enhances the electrostatic interaction between ZIF-8-NH2 and PM, resulting in NZCA with superior PM filtration performance (filtration efficiency and quality factor: PM2.5: 92%, 0.054; PM10: 96%, 0.068) compared to ZCA without sacrificing the pressure drop. Furthermore, ZIF-8-NH2 modified cellulose filters were easy to regenerate and exhibited excellent reusability. This work paves the way for the rational design of ligand-modified MOF/cellulose filters for the efficient removal of PM from air, which has important implications for solving environmental problems and energy crises.

Binary-Cooperative Ultrathin Porous Membrane for Gas Separation.

The construction of ultrathin porous membranes with stable structures is critical for achieving efficient gas separation. Inspired by the binary-cooperative structural features of bones and teeth-composed of rigid hydroxyapatite and flexible collagen, which confer excellent mechanical strength-a binary-cooperative porous membrane constructed with gel-state zeolitic imidazolate frameworks (g-ZIFs), synthesized using a metal-gel-induced strategy, is proposed. The enlarged cavity size and flexible frameworks of the g-ZIF nanoparticles significantly improve gas adsorption and diffusion, respectively. After thermal treatment, the coordination structures forming rigid segments in the g-ZIF membranes appear at the stacked g-ZIF boundaries, exhibiting a higher Young's modulus than the g-ZIF nanoparticles, denoted as the flexible segments. The g-ZIF membranes demonstrate excellent tensile and compression resistances, attributed to the effective translation of binary-cooperative effects of rigidity and flexibility into the membranes. The resulting dual-aperture structure, composed of g-ZIF nanoparticles surrounded by nanoscale apertures at the boundaries, yields a membrane with a stable CO2 permeance of 4834 GPU and CO2/CH4 selectivity of 90 within 3.0MPa.

Enhanced visible light-assisted photocatalytic activity of g-C3N4 decorated with ZIF-8 and AgI ternary heterojunctions

Fabrication of a suitable photocatalyst system that responds to visible light has become a requirement for photocatalytic environmental remediation processes. For better transfer/separation of photogenerated-charges, successful interfacial engineering to build photocatalytic heterojunctions is essential for improving the photodegradation performance. Herein, ternary composites of zeolitic-imidazolate-framework-8 (ZIF-8) coupled with AgI nanoparticles assembled on g-C3N4 have been fabricated, characterized using XRD, FESEM, EDX, TEM, PL, UV–visible DRS, and N2-adsorption–desorption, and used as visible-light-driven photocatalysts for photocatalytic destruction of methylene blue (MB). The ternary AgI/ZIF-8/g-C3N4 photocatalyst achieved superb photodestruction activity (94.2 %) within 120 min. Besides, the first-order degradation rate constant reached 0.02431 min−1, which was nearly 1.5, 2.5, 4.5, and 5.5 times greater than that reached by ZIF-8/g-C3N4 (0.01628 min−1), g-C3N4 (0.00941 min−1), AgI (0.00542 min−1) and ZIF-8 (0.00441 min−1), respectively. The improved photocatalytic behavior was accredited to the synergistic influence of the photo-charge carrier transfer/separation pathway and the electron mediation assisted by ZIF-8. The trapping tests supported the recommended photocatalytic mechanism, which suggested that the O2− radicals were the main reacting agents in this process. The parameters affecting the photodegradation, including the AgI/ZIF-8/g-C3N4 dose, the solution pH, and the MB concentration were systematically tested in this work. Furthermore, the AgI/ZIF-8/g-C3N4 demonstrated good degradation stability after multi-consecutive rounds (only 1 % deduction in its activity after 5 rounds), and thus, it is projected to be a promising photocatalyst in wastewater treatment.

Laser‐Induced Transformation of ZIF‐8 into Highly Luminescent N‐Doped Nanocarbons for Flexible Sensors

AbstractMetal–organic frameworks (MOFs) like the zeolitic imidazolate framework (ZIF‐8) have a high surface area, tunable porosity, and robust thermal and chemical stability, making them attractive candidates for various applications. Here, a strategy is shown that spans that functionality and provides strong photoluminescence (PL) emission, unlocking ZIF‐8‐based materials for chemical and temperature sensors based on PL. The approach is based on laser processing that dramatically boosts the PL response of laser‐irradiated ZIF‐8 (LI ZIF‐8), achieving a 70‐fold increase in intensity relative to the pristine material. The PL characteristics of the irradiated material can be easily tuned by varying the laser power and irradiation time with in situ and real‐time spectroscopic analysis providing insights into the process dynamics. It is found that the observed PL enhancement is primarily due to the laser‐induced transformation of ZIF‐8 into nitrogen‐doped nanocarbons and ZnO nanostructures. The versatility of this laser processing approach is leveraged to create flexible electronics by integrating the LI ZIF‐8/nanocarbon architectures into thermoplastic polyurethane (TPU). The multifunctional composite material shows excellent performance as flexible electrodes for human‐body monitoring applications, as well as both temperature and flexure sensors with remarkable mechanical resilience.

Facile Fabrication of Zeolitic Imidazolate Framework-8@Regenerated Cellulose Nanofibrous Membranes for Effective Adsorption of Tetracycline Hydrochloride.

The excessive utilization of antimicrobials in humans and animals has resulted in considerable environmental contamination, necessitating the development of high-performance antibiotic adsorption media. A significant challenge is the development of composite nanofibrous materials that are both beneficial and easy to fabricate, with the aim of improving adsorption capacity. Herein, a new kind of zeolitic imidazolate framework-8 (ZIF-8)-modified regenerated cellulose nanofibrous membrane (ZIF-8@RC NFM) was designed and fabricated by combining electrospinning and in situ surface modification technologies. Benefiting from its favorable surface wettability, enhanced tensile strength, interconnected porous structure, and relatively large specific surface area, the resulting ZIF-8@RC NFMs exhibit a relatively high adsorption capacity for tetracycline hydrochloride (TCH) of 105 mg g-1 within 3 h. Moreover, a Langmuir isotherm model and a pseudo-second-order model have been demonstrated to be more appropriate for the description of the TCH adsorption process of ZIF-8@RC-3 NFMs. Additionally, this composite fibrous material could keep a relatively stable adsorption capability under various ionic strengths. The successful fabrication of the novel ZIF-8@RC NFMs may shed light on the further development of wastewater adsorption treatment materials.

Lithiophilic Reduced Graphene Oxide/Carbonized Zeolite Imidazolate Framework-8 Composite Host for Stable Li Metal Anodes.

Lithium (Li) metal is regarded as a next-generation anode material owing to its high energy density. However, issues such as dendritic growth and volume changes during charging and discharging pose significant challenges for commercialization. We propose using lithiophilic reduced graphene oxide (rGO) and carbonized zeolite imidazolate framework-8 (C-ZIF-8) composites as host materials for Li to address these problems. The rGO/C-ZIF-8 composites are synthesized through a simple redox reaction followed by carbonization and are characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS). The roles of chemical composition, characteristics, and morphology are demonstrated. As a result of these favorable structural and functional properties, the Li symmetric cell with rGO/C-ZIF-8 exhibits a stable voltage profile for more than 100 h at 1 mA cm-2 without short-circuiting. A relatively low Li plating/stripping overpotential of ~101.5 mV at a high current density of 10 mA cm-2 is confirmed. Moreover, a rGO/C-ZIF-8-Li full cell paired with a LiFePO4 cathode demonstrates good cyclability and rate capability.

Investigating the Structure of Defects in Heterometallic Zeolitic Imidazolate Frameworks ZIF-8(Zn/Cd) and Its Interaction with CO2 Using First-Principle Calculations

Inducing defect in metal-organic frameworks (MOFs) is one of the strategies to modify the structure and properties of this functional material. Defect may occur in a pristine MOF due to missing organic linkers, metal centres and/or other structural behaviours. In this study, the structure of defects in multicomponent MOFs especially heterometallic MOFs of zeolitic imidazolate framework (ZIF-8(Zn/Cd)) was examined to unveil the possible preference defect formation due to missing 2-methylimidazolate (MeIm) and metal centres of Cd2+ and Zn2+. Assuming defect formation due to the reaction between ZIF-8(Zn/Cd) and water, MeIm linker removal is energetically lower than removing metal centres of either Cd2+ or Zn2+. But, the MeIm linker is easier to be removed when it is connected to Cd2+ (Cd-MeIm-Cd) than when it is connected to Zn2+ (Zn-MeIm-Zn). Defect in ZIF-8(Zn/Cd) affects the band gap energy to give slightly lower value than it in pristine ZIF-8(Zn/Cd). Non-covalent interaction (NCI) and interaction region indicator (IRI) analyses were also performed to indicate possible intermolecular forces such as van der Waals and attractive forces present in non-defective and defective ZIF-8(Zn/Cd). The presence of defects in mixed-metal ZIF-8(Zn/Cd) was also tested for its potential use on CO2 adsorption. The interaction energy of CO2 inside defective ZIF-8(Zn/Cd) indicates an exothermic behaviour where CO2 molecule has a preference to be adsorbed inside the framework. This is especially when the capping agents at the defective ZIF-8(Zn/Cd) sites are removed to give open metal sites. This study provides insight how defects in multicomponent MOFs might presence affecting the structural and properties changes. Copyright © 2024 by Authors, Published by BCREC Publishing Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).

Novel [plant essential oils@γ-CD MOF]/ZIF-8 strategy to remove bacteria and dye from bacterial staining wastewater

A novel MOF-on-MOF ([plant essential oils@γ-CD MOF]/ZIF-8) strategy was established in this work, in which a cyclodextrin metal–organic framework (γ-CD MOF) loaded with plant essential oils (cinnamon and oregano oils, COEO) was combined with zeolitic imidazolate framework (ZIF-8) to produce ([COEO@γ-CD MOF]/ZIF-8) for the removal of bacteria and dyes from bacterial staining wastewater. Adsorption isotherm and kinetic studies showed that [COEO@γ-CD MOF]/ZIF-8 could adsorb methylene blue (MB) by monolayer chemisorption with a Qmax of 111.6 mg/g. No bacterial colonies grew on plates treated with [COEO@γ-CD MOF]/ZIF-8, and scanning electron microscope (SEM) images showed a disruption of E. coli and S. aureus structures. This work offers a simple and green method for treating bacterial staining wastewater in microbiology labs.

Functionalization strategy of carboxymethyl cotton gauze fabrics with zeolitic imidazolate framework-67 (ZIF-67) as a recyclable material for biomedical applications

The accumulation of uremic toxins in the human body poses a deadly risk because it causes chronic kidney disease. To increase the effectiveness of hemodialysis and raise the survival rate, these toxins must be effectively removed from the bloodstream. Developing effective materials for removing these dangerous substances requires a thorough understanding of the interactions between an adsorbent and the uremic toxins. Thankfully, metal-organic frameworks (MOFs) have shown considerable promise for the identification and treatment of kidney disorders. Herein, cotton gauze fabrics (CGF) were carboxylated using monochloroacetic acid to produce carboxymethylated cotton gauze fabrics (CM-CGF). CM-CGF was subsequently decorated in situ with zeolitic imidazolate framework-67, resulting in carboxymethylated cotton gauze fabrics-zeolitic imidazolate framework-67 (CM-CGF-ZIF). The CGF, CM-CGF, and CM-CGF-ZIF were evaluated for potential kidney applications by removing uric acid and creatinine from mimic blood. The results showed that CM-CGF-ZIF had the highest adsorption of uric acid and creatinine. The maximum adsorption capacity of uric acid and creatinine was 164 and 222 mg/g for CM-CGF-ZIF, respectively, compared to 45 and 67 mg/g for CGF. CM-CGF-ZIF showed excellent antibacterial activity, good antifungal activity, low cytotoxicity, and a satisfactory level of blood compatibility.

CFD Simulation of Chaotic Flow Characteristics in an Oscillating Feedback Microreactor and Its Application for Preparing Zeolitic Imidazolate Framework-8 Nanoparticles

CFD Simulation of Chaotic Flow Characteristics in an Oscillating Feedback Microreactor and Its Application for Preparing Zeolitic Imidazolate Framework-8 Nanoparticles

ZIF-8 as a pH-Responsive Nanoplatform for 5-Fluorouracil Delivery in the Chemotherapy of Oral Squamous Cell Carcinoma.

5-fluorouracil (5-FU), a chemotherapeutic agent against oral squamous cell carcinoma (OSCC), is limited by poor pharmacokinetics and toxicity. The pH-sensitive zeolite imidazolate framework-8 (ZIF-8) may increase the selectivity and length of 5-FU released into the acidic tumor microenvironment. This study examined the in vitro 5-FU absorption and release profiles of ZIF-8, and then progressed to cytotoxicity assays using the OSCC primary cell line SCC7. The 5-FU loading capacity of ZIF-8 was calculated with UV-vis spectroscopy (λ = 260 nm). 5-FU release was quantified by submerging 5-FU@ZIF-8 in pH 7.4 and 5.5 acetate buffer over 48 h. For the cytotoxicity assays, 5-FU, ZIF-8, and 5-FU@ZIF-8 were added to SCC7 cultures at 25, 50, and 100 μg/mL. Cell viability was assessed through toluidine blue staining and further quantified through transcriptomic RNA sequencing. ZIF-8 stabilized at a maximum absorption of 2.71 ± 0.22 mg 5-FU, and released 0.66 mg more 5-FU at pH 5.5 than 7.4 for at least 72 h. The cytotoxicity assays showed that 5-FU@ZIF-8 had a synergistic inhibitory effect at 50 μg/mL. The RNA sequencing analysis further revealed the molecular targets of 5-FU@ZIF-8 in SCC7. 5-FU@ZIF-8 may release 5-FU based on the pH of the surrounding microenvironments and synergistically inhibit OSCC.

In-situ co-growth of ZIF-8-derived bio-carbon spheres with meso-macroporous hierarchy for stable and rapid carbon dioxide capture

Efficient carbon dioxide (CO2) capture from post-combustion flue gases is crucial for industrial applications. Adsorbents with high adsorption capacity, exceptional stability, high selectivity, and low cost are essential to meet these requirements. In this study, we present the synthesis of bio‑carbon spheres derived from zeolitic imidazolate framework-8 (ZIF-8) using a macro-fluidic technique. The bio‑carbon spheres integrate ZIF-8 for structural orientation and chitosan for the directional assembly of ZIF-8, thereby addressing the limitations of low strength in chitosan-derived carbon spheres and the challenge of macroscopic shaping of ZIF-8 particles. Additionally, the incorporation of ZIF-8 and the enhancement of the carbon skeleton increased the meso-macroporosity, improving CO2 transport and adsorption performance. The bio‑carbon spheres demonstrated a 46.9% higher CO2 adsorption capacity (101 kPa, 1.40 mmol·g−1) compared to pure chitosan carbon granules (101 kPa, 0.96 mmol·g−1) and a 17.8% faster mass transport rate compared to ZIF-8 carbon particles. Moreover, the bio‑carbon spheres exhibit a low wear rate in a simulated fluidized bed, good thermal stability, and stable cyclic regeneration performance. This study offers a novel strategy for developing industrially applicable adsorbents with hierarchical pore structures to enhance CO2 capture.

ZIF-67@polyvinylidene fluoride mixed matrix membranes towards improved hydrogen separation performance.

This work is primarily focused on overcoming the limitations of polymeric membranes in achieving the balance between permeability and selectivity of the separation performance. The filler, Zeolitic imidazole framework -67 (ZIF-67) nanoparticles were synthesised in cubical morphology using hexadecyltrimethylammonium bromide (CTAB) as a surfactant via the wet-chemical method. The uniform particles with particle sizes ranging between 120-180nm were incorporated into the polyvinylidene fluoride (PVDF) matrix to fabricate mixed matrix membranes via the phase inversion method. These mixed matrix membranes were systematically characterised to confirm the chemical, structural and morphological properties of the materials and membranes. Furthermore, the membranes showed a 56.5% improvement in their mechanical properties. The results confirm that 5 wt.% ZIF-67/PVDF membrane showed the best separation results compared to its pure counterpart. The permeability of H₂ gas was reported to be 1,094,511 Barrer, with selectivities of 3.03 for H₂/CO₂ and 3.06 for H₂/N₂. This represents a 210.6% increase in the permeability of H₂ gas. These results demonstrate the influence of ZIF-67 loading in the PVDF polymer matrix along with the potential of ZIF-67/PVDF mixed matrix membranes in the field of hydrogen separation and purification.

Dual response signal CdTe QDs@ZIF-8 with butterfly spectrum for dual-mode fluorescence/colorimetric detection of tetracycline in animal feeds.

In this study, a ratiometric fluorescent sensor CdTe QDs@ZIF-8 with butterfly spectra is successfully constructed by in situ encapsulating mercaptopropionic acid-modified CdTe quantum dots in zeolitic imidazolate framework-8 (ZIF-8) with a simple strategy, and used for the detection of tetracycline in fluorescence/smartphone colorimetry dual-mode. ZIF-8 not only reduces the agglomeration of the quantum dots but also surprisingly generates a new green fluorescence signal at 524nm while the red fluorescence of the CdTe quantum dots at 650nm quenches when tetracycline is added. The two opposing fluorescence signals create a butterfly-shaped fluorescence spectrum, allowing the sensor to detect tetracycline over a linear range of 0-70μM with the detection limit (LOD) of 0.0155μM by using a ratiometric fluorescence technique. What is more, based on the obvious color change of the fluorescent sensor gradually from red to green under UV light, a highly stable point-of-care testing sensor has been developed for on-site detection of tetracycline through color recognition by smartphones, which can be used for real-time detection of this antibiotic in the range of 0-1000μM with the LOD of 0.0249μM. This work provides a simple and efficient method for the on-site detection of tetracycline.

Aqueous co-solvent synthesis of Zeolitic Imidazolate Frameworks: The impact of co-solvents in the crystal growth kinetics

Zeolitic Imidazolate Frameworks (ZIFs) have been widely studied in recent decades in a variety of applications. However, a fundamental understanding of crystal growth kinetics as well as their formation mechanisms has been very limited. Underpinning such mechanisms might be of key importance for the predictable synthesis of ZIFs to rationally tune the structural and morphological properties for respective applications. Herein, the crystal growth kinetics and structural evolution of ZIF-8 crystals in various aqueous co-solvent reaction environments were studied with respect to synthesis time. By tracking the nucleation, crystal growth, stabilization and ripening, three potential kinetic formation mechanisms were proposed. More specifically, with methanol, isopropanol and acetone, a fast nucleation rate and crystal growth occurred within 60 minutes (min) at room temperature. However, ethanol and n-propanol showed prolonged nucleation which resulted in the slow formation of ZIF-L/ZIF-8 mixed phases at the early stage. Phase transformation to pure ZIF-8 was observed in longer syntheses. Nitrogen-containing solvent, N, N–dimethyl formaldehyde (DMF), was found to induce both nucleation and growth, resulting in large crystals in less than 60 min of fabrication. In each case, the crystal formation follows Avrami's classical model. Hence, by understanding the effects of co-solvents in ZIF nucleation, crystallization and phase selection, one can rationally design the crystals with predictable crystallinity, size, morphology, purity and surface properties for targeted applications such as adsorption of small molecules from aqueous mixtures.

Integrating sodium cholate-modified MOF hybrid lipase and solubilization of hydrophobic candidates into a step for liganding fishing lipase inhibitors from Nelumbinis Folium

Enzyme immobilization by metal organic frameworks (MOFs) is an efficient way for screening active constituents in natural products. However, the enzyme’s biocatalysis activity is usually decreased due to unfavorable conformational changes during the immobilization process. In this study, sodium cholate was firstly used as the modifier for zeolitic imidazolate framework-8 (ZIF-8) immobilized lipase to increase both the stability and activity. More importantly, with the help of solubilization of sodium cholate, a total of 3 flavonoids and 6 alkaloids candidate compounds were fished out. Their structures were identified and the enzyme inhibitory activities were verified. In addition, the binding information between the candidate compound and the enzyme was displayed by molecular docking. This study provides valuable information for the improvement of immobilized enzyme activity and functional active ingredients in complicated medicinal plant extracts.

Shaping Phenolic Resin-Coated ZIF-67 to Millimeter-Scale Co/N Carbon Beads for Efficient Peroxymonosulfate Activation.

Catalytic performance decline is a general issue when shaping fine powder into macroscale catalysts (e.g., beads, fiber, pellets). To address this challenge, a phenolic resin-assisted strategy was proposed to prepare porous Co/N carbon beads (ZACBs) at millimeter scale via the phase inversion method followed by confined pyrolysis. Specially, p-aminophenol-formaldehyde (AF) resin-coated zeolitic imidazolate framework (ZIF-67) nanoparticles were introduced to polyacrylonitrile (PAN) solution before pyrolysis. The thermosetting of the coated AF improved the interface compatibility between the ZIF-67 and PAN matrix, inhibiting the shrinkage of ZIF-67 particles, thus significantly improving the void structure of ZIF-67 and the dispersion of active species. The obtained ZACBs exhibited a 99.9% removal rate of tetracycline (TC) within 120 min, with a rate constant of 0.069 min-1 (2.3 times of ZIF-67/PAN carbon beads). The quenching experiments and electron paramagnetic resonance (EPR) tests showed that radicals dominated the reaction. This work provides new insight into the fabrication of high-performance MOF catalysts with outstanding recycling properties, which may promote the use of MOF powder in more practical applications.