The purpose of the article is to highlight the prospects of philosophy in the context of the post-scientific dimension and the formation of new cognitive and value constants of the scientific worldview. The goals of scientific research are focused on reconciling anthropo-bio- and (recently) technocentric concepts in a single philosophical paradigm of ecocentric orientation. With the help of the methods of the analytical cluster, a number of priority areas of the philosophy of the future are formed, in which the roles of humans, nature, and technology are clearly distinguished. The philosophical and methodological approaches define two strategies of interrelations of the key components of the world picture: confrontation (dialectical) and interaction (synergistic). The results of the study point out the need for a philosophical understanding of the problem of “nature” in the context of new socio-cultural conditions associated with the establishment of a post-scientific worldview. The authors propose a new format of interaction between human and natural dimensions, which will be guided by the values of responsibility while ensuring an appropriate level of cognitive activity (with an obvious impact of human activity on the natural world). An attempt to add an innovative technological element to the usual dichotomy of anthropocentrism and biocentrism should be considered a promising area of research into the post-scientific dimension of the philosophical worldview of the future. Thus, civilisational progress is expected to be characterised by transformational activity, which is intended to outline the guidelines for the coexistence of the main elements of the world order and to form an effective model of human-nature interaction. The philosophy of the future is associated with the ideological and mental support of civilisational progress and a picture of the world in which humans, nature, science, technology, religion, and other elements form a synergistic interaction of development and well-being.