Purpose. The aim of the study was to analyse the most promising ways to use natural light in new modern construction projects and in the reconstruction of existing buildings and modern methods of designing artificial lighting and interior design using new sources, taking into account the psychophysiological condition of the human body. Methods. In order to achieve the set objectives, the current standards of lighting environment, design solutions for natural light in workplaces, were analysed and the ecological and climatic conditions of lighting on the example of Dnipro were taken into account. Existing artificial lighting systems were analysed, the impact of lighting levels was considered, as well as sources on the state of human health, ability to work and safety. Topicality. The article considers the problem of improving the safety and comfort of the lighting environment under optimal working conditions, which preserve the health of workers and create the prerequisites for maintaining a high level of efficiency. The scientific novelty lies in a comprehensive approach to evaluating the hygienic characteristics of light and colour environment, as well as the application of results for the calculation of lighting systems and recommendations for the design and interior decoration of premises for work of high visual complexity. Practical significance. The research results could be provided to ensure safety of workers in the premises, with categories of work of high, very high and highest precision. The importance of the work lies in the need to take into account the complex effect of a light-coloured environment on the state of workers. The research results proved that safe and comfortable lighting should be designed on the basis of a multifactor model that takes into account the exposure of light of different origins at a workplace with obligatory consideration of the impact on human health during work, as well as determining the energy efficiency of workplace lighting