Introduction - Motorcycle accidents are the leading cause of blunt trauma and 95% of these are associated with underlying fracture/dislocation. Isolated peripheral vascular trauma without skeletal involvement is rare. Motor scooter handlebar syndrome (MSHS) is a type of isolated blunt vascular injury to the iliac/ femoral vessels without any associated bony injury, following direct impact of a handlebar to the affected part. Considering the increase in the number of two wheeler vehicles and associated trauma, it is likely that this pattern of injury is on the rise.The aim of this study is to review existing literature regarding the incidence, presentation, diagnosis and management of MSHS. Methods - A systematic review of literature was performed according to the PRISMA guidelines using Pubmed, Ovid and EMBASE databases. Keywords used were blunt injuries, handlebar injuries, femoral artery injuries, iliac artery injuries and aortic injuries. English literature and human studies were the limits applied. In addition snowballing and grey literature review was done. A total of 2709 articles were reviewed, out of which 2677 articles were excluded. The remaining 32 articles, along with one of our unpublished case report, were used in qualitative synthesis Results - Since the first published case of MSHS in 1965, a total of 39 cases were reported. 38 out of the 39 cases were reported in men. The mean age was 21.9 years( range 9-75 years). 17 patients (44.7%) presented immediately following the trauma and the rest 21(55.3%) presented late( range 2 days to 10 years). Majority of the injuries involved Common femoral artery (CFA) (48.7%, 4 transections and 15 occlusions), followed by External iliac artery (30.8%, one transection and 11 occlusions), Common iliac artery (15.4%, 5 occlusions and one pseudo aneurysm) and the abdominal aorta ( 2.6%, one case of multiple lacerations).Two cases of venous injury (5.2%), one in the Common femoral vein and one in the External iliac vein were also reported. Treatment options utilised include open surgery in 34 patients (89.5%), endovascular in 2 patients (5.2%), hybrid approach in one patient (2.6%) and therapeutic anticoagulation in one patient (2.6%). Conclusion - There were less than forty reported cases of MSHS in the medical literature. CFA was the commonest vessel involved and occlusion/ stenosis was the predominant lesion. The vascular injury was frequently missed at the time of trauma and surgery has been the treatment of choice.