In this work, the FePO4-coated spinel LiNi0.5Mn1.5O4 cathode materials are successfully prepared by the solid-state reaction and wet precipitation method. The effect of FePO4 coating on the physical and electrochemical properties were examined by X-ray diffraction (XRD), micro-Raman spectroscopy (micro-Raman), scanning electron microscopy (SEM), transmission electron microscopy (TEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), C-rate and cycling tests (at 25 oC and 55 oC). The results show that FePO4 coating can greatly mitigate the dissolution of Mn ions into electrolyte from LiNi0.5Mn1.5O4, resulting in excellent cycling stability and rate capability. In all samples tested, it was found that the sample containing 1 wt.% of FePO4 coating presents the best electrochemical performance. It delivers discharge capacities of 112.05 mAh g-1 (at 25 oC) and 101.71 mAh g-1 (at 55 oC) at 1 C rate, with the corresponding capacity retention of 99.3% and 88.4% after 100 cycles. In addition, the cathode material presents a superior high discharge capacity of 104.92 mAh g-1 and 91.70 mAh g-1 at 5 C and 10 C rates, respectively. More importantly, the enhancement of electrochemical performance is related to the fact that the phosphate coating layer effectively diminishes the side reactions, which occurred at interface of the 5 V LiNi0.5Mn1.5O4 cathode and the electrolyte. Keywords: lithium-ion batteries, spinel LiNi0.5Mn1.5O4, 5V cathode materials, FePO4-coated, high-temperature.