Western Cape Region Research Articles

When was silcrete heat treatment invented in South Africa?

Silcrete heat treatment, along with a suit of other innovations, have been used to argue for an early onset of modern or complex behaviours in Middle Stone Age hominins. This practice was confined to South Africa’s southern and western Cape regions where it was continuously practised since the Still Bay industry. However, the exact moment that this technological advancement occurred still remains unclear. This is partly due to the scarcity of silcrete assemblages dating to the first half of the Middle Stone Age. To determine when silcrete heat treatment began to be well-established, we compare the silcrete assemblages from two archaeological sites situated along the south western coast of South Africa: Hoedjiespunt 1, one of the earliest Middle Stone Age silcrete assemblages dating to 119–130 ka, and Duinefontein 2, one of the latest Early Stone Age assemblages dating to 200–400 ka. Our results suggest that the invention of heat treatment occurred sometime between 130 ka and 200–400 ka, as it is still absent in the earlier assemblage but fully mastered and well-integrated in the recent one. This period corresponds to the time that Homo sapiens became the major hominin species in the southern African subcontinent and it is roughly the time that silcrete use became widespread in the second half of the Cape-coastal Middle Stone Age. This opens interesting new questions on the relation between silcrete use and heat treatment and on why early modern humans spontaneously invented heat treatment when they began using silcrete in the Cape region.

Different aspects of electronic media use, symptoms and neurocognitive outcomes of children and adolescents in the rural Western Cape region of South Africa

BackgroundElectronic media use is increasing in low- and middle-income countries, thus we aim to investigate the prevalence of different aspects of e-media use and its association to symptoms and neurocognitive outcomes in rural South Africa. MethodsIn the cohort study, “Child health Agricultural Pesticide study in South Africa (CapSA)”, of 1001 children and adolescents, aged 9–16 years, we enquired at baseline about the following aspects of e-media use: (1) call duration (2) total screen time (3) night-time awakenings from mobile phone use, and (4) Mobile Phone Problematic Use. Four health outcomes were included: sleep disturbance, health related quality of life (HRQoL), headaches and cognitive performance, assessed through six tests on domains of attention, memory and processing speed, using the iPad-based software, CAmbridge Neuropsychological Test Automated Battery (CANTAB). Linear regression analysis adjusted for relevant confounders was conducted with categorized exposure variables low, medium and high use. ResultsOne third of the cohort (31.8%) are mobile phone users reporting average duration of calls per day up to 75 min (mean = 2.5 mins; SD = 8.9 mins). Amongst 46% of the cohort who report e-media device use, total screen time ranged from 1 min to 441 min (mean = 28.3; SD = 53.0). Findings Amongst those reporting regular night-time awakenings (≥1 times per week) from mobile phones, HRQol declined by 2.9 (95% CI: −6.1, 0.3), the sleep disturbance score increased by 2.0 (1.1, 2.9) units and headache impact score significantly increased by 5.4 (2.6; 8.2) units compared to non-exposed. Cognitive performance scores tended to be slightly improved mostly in moderate e-media users. The reaction response speed was consistently improved amongst all four exposure groups compared to non-users. ConclusionThese results are among the first from Africa on benefits and risks associated with e-media use. Our findings imply that with regard to the education of adolescents, a vigilant balance is needed to profit from the beneficial effects of moderate e-media use on cognition, while preventing the negative side effects for HRQoL, sleep disturbance and headache severity.

Population genetics of the invasive wasp Vespula germanica in South Africa

The German wasp (Vespula germanica) is a highly successful invader on a global scale. These wasps were first observed in the Western Cape region in South Africa in 1972, and they have the potential to expand their range and cause significant damage to the native biodiversity. Our study used nuclear (DNA microsatellites) and mitochondrial DNA (mtDNA) from 42 wasp colonies to analyse the population genetics of V. germanica in their invaded South African range. We sequenced three mitochondrial genes; cytochrome c oxidase I, cytochrome b and cytochrome c oxidase II. We found six mtDNA haplotypes present in South Africa. Although only a single fertilized queen is sufficient for the establishment of a wasp nest, the probability of a single introduced queen to successfully establish a nest and a population is very small. If multiple queens were introduced at the same time, the probability for more than one haplotype being transferred to the new population increases. Therefore, the true number of queen introductions occurred in South Africa can be inferred to be between two and six. We examined nine microsatellite loci and found weak-to-no genetic sub-structuring, likely due to high dispersal rates. We concluded that German wasps in South Africa maintain a homogenous population with movement of individuals between localities.

How different Cape Town residential suburbs helped avert Day Zero

AbstractBetween 2015 and 2018, the Western Cape region of South Africa experienced three consecutive years of below average rainfall. The local authority of Cape Town imposed water restrictions to avert ‘Day Zero’, an event that was expected to occur if the storage capacity of the main dams supplying the city fell to below 13.5%. This study analyses how different residential areas in Cape Town responded to water restrictions and tariffs that were imposed from January 2016 to October 2018 during the midst of the water crisis. It further explores the potential implications for tariff adjustments that were designed to sustain water conservation measures beyond the drought, while also being sensitive to the ability of poorer households to access sufficient water at an appropriate per capita cost. Different socio-economic groups displayed a different response to the restrictions. A delay or lag-time was observed in lower-income suburbs during the initial phases of water restrictions, while middle- and higher-income suburbs responded immediately. Once the water crisis eased by mid-2018 and restrictions were reduced, more affluent suburbs began relaxing their water conservation efforts. Nevertheless, lower-, middle-, and higher-income suburbs significantly reduced their water demand by 32, 59, and 58%, respectively, over the study period. It can therefore be concluded that water restrictions and accompanying tariffs altered water use of all users regardless of socio-economic status.

Evaluation of the Beck Anxiety Inventory in predicting generalised anxiety disorder among individuals seeking HIV testing in the Western Cape province, South Africa.

BackgroundRoutine anxiety screening is needed among HIV test seekers, given the lack of health-care professionals with the ability to identify individuals with generalised anxiety.AimThe aim of this study was to determine the effectiveness of the Beck anxiety inventory (BAI) in predicting caseness for generalised anxiety disorder (GAD) among persons seeking HIV testing, using the structured clinical interview for the DSM-5 (SCID-5) as the gold standard.SettingFive HIV testing sites in the Western Cape region of South Africa.MethodWe recruited 500 persons seeking HIV testing from five non-medical testing sites in the Western Cape, South Africa. We used receiver operating curve analysis to determine the optimal cut-off point on the BAI to discriminate between GAD caseness and non-caseness.Results3.4% of the sample met the DSM-5 criteria for a diagnosis of GAD. Using an optimal cut-off point of 21.5, the sensitivity and specificity of the BAI were 82% and 80%, respectively. The positive predictive value was 13%, while the negative predictive value was 99%.ConclusionOur data suggest that while the BAI may be used to screen for GAD, it is likely to yield a high number of false positives. A two-tiered method may be useful to mitigate against case over-identification. Thus, in a public health setting, persons screening positive on the BAI should receive a diagnostic interview to determine whether they are true cases for GAD. Within resource-constrained communities in South Africa, referral trajectories should be integrated with routine screening and HIV testing.

Fall History and Associated Factors Among Adults Living With HIV-1 in the Cape Winelands, South Africa: An Exploratory Investigation.

BackgroundPeople with HIV-1 (PWH) exhibit a high fall incidence and increased fracture risk. As little is known about fall frequency and associated factors in PWH residing in lower-middle-income countries (LMIC), we investigated fall frequency, bone quality, and factors associated with fall history in a South African cohort.MethodsFifty PWH without obvious predisposing factors for mobility impairments attending 2 public primary care clinics in the Western Cape region participated. Demographic, clinical, and physical performance data were collected. Falls were assessed retrospectively over 12 months. Mobility and balance were evaluated using a physical performance battery. Bone mineral density was screened using quantitative ultrasound (QUS). Associations between variables and falls grouping were analyzed using chi-square tests, t tests, and Mann-Whitney U tests, and effect sizes (ES) were calculated.ResultsThirty-four percent of PWH (median age, 36.6 years) reported falling during the past year, and 41.2% of fallers reported multiple falls. Fallers had more mobility problems (P = .013), higher fear of falling (P = .007), higher fracture history (P = .003), worse balance performance (P < .001), higher proportions of detectable viral loads (P = .021), and poorer bone quality (P = .040). Differences were of medium to large ES.ConclusionsThis exploratory study is the first to show that relatively young South African PWH without obvious predisposing factors for gait and balance impairments experience falls. The observed fall-associated factors warrant further research using larger samples and longitudinal designs to ascertain fall predictors within this population.

Rainfall and river flow trends for the Western Cape Province, South Africa

Climate change has the potential to alter the spatio-temporal distribution of rainfall, subsequently affecting the supply and demand of water resources. In a water-stressed country such as South Africa, this effect has significant consequences. To this end, we investigated annual and winter rainfall and river flow trends for the Western Cape Province over two periods: 1987–2017 and 1960–2017. Annual rainfall for the most recent 30-year period shows decreasing trends, with the largest magnitude of decrease at the SA Astronomical Observatory rainfall station (-54.38 mm/decade). With the exception of the significant decreasing winter rainfall trend at Langewens (-34.88 mm/decade), the trends vary between stations for the period 1960–2017. For the period 1987–2017, statistically significant decreasing winter trends were found at four of the seven stations, and range from -6.8 mm/decade at Cape Columbine to -34.88 mm/decade at Langewens. Similarly, the magnitudes of decreasing winter river flow at Bree@Ceres and Berg@Franschoek are greater for the more recent 30-year period than for 1960–2017. Correlation coefficients for Vilij@Voeliv rainfall and four river flow stations Berg@Franschoek, Bree@Ceres, Wit River@Drosterkloof and Little Berg@Nieuwkloof) are stronger for shorter periods (i.e. 1987–2017 and 2007–2017) than that for the longer period, 1960–2017. The Intergovernmental Panel on Climate Change emphasises the importance of studies to assist with model prediction uncertainties. To this end, our study expands the understanding of regional hydrological responses to rainfall change in the water stressed region of the Western Cape Province.&#x0D; Significance:&#x0D; &#x0D; Historical trend analyses provide the basis for future rainfall and river flow projections and also improve our understanding of hydrological responses to rainfall change, which is important for water resource planning and management in light of recent rainfall shortages experienced in the Western Cape region.&#x0D; Anthropogenic and natural influences on river systems must be taken into account when assessing the impact of rainfall changes on river flow because these factors ultimately affect water resource management.&#x0D; We identified decreasing winter rainfall trends across the Western Cape Province for the most recent three decades.&#x0D;

Geographic variation of reproductive traits and competition for pollinators in a bird-pollinated plant.

Geographic variation in the reproductive traits of animal‐pollinated plants can be shaped by spatially variable selection imposed by differences in the local pollination environment. We investigated this process in Babiana ringens (Iridaceae), an enigmatic species from the Western Cape region of South Africa. B. ringens has evolved a specialized perch facilitating cross‐pollination by sunbirds and displays striking geographic variation in perch size and floral traits. Here, we investigate whether this variation can be explained by geographic differences in the pollinator communities. We measured floral and inflorescence traits, and abiotic variables (N, P, C, and rainfall) and made observations of sunbirds in populations spanning the range of B. ringens. In each population, we recorded sunbird species identity and measured visitation rates, interfloral pollen transfer, and whether the seed set of flowers was pollen limited. To evaluate whether competition from co‐occurring sunbird‐pollinated species might reduce visitation, we quantified nectar rewards in B. ringens and of other co‐flowering bird‐pollinated species in local communities in which populations occurred. Variation in abiotic variables was not associated with geographical variation of traits in B. ringens. Malachite sunbirds were the dominant visitor (97% of visits) and populations with larger‐sized traits exhibited higher visitation rates, more between‐flower pollen transfer and set more seed. No sunbirds were observed in four populations, all with smaller‐sized traits. Sunbird visitation to B. ringens was not associated with local sunbird activity in communities, but sunbird visitation was negatively associated with the amount of B. ringens sugar relative to the availability of alternative nectar sources. Our study provides evidence that B. ringens populations with larger floral traits are visited more frequently by sunbirds, and we propose that visitation rates to B. ringens may be influenced, in part, by competition with other sunbird‐pollinated species.

The relationship between childhood trauma and schizophrenia in the Genomics of Schizophrenia in the Xhosa people (SAX) study in South Africa.

Evidence from high-income countries suggests that childhood trauma is associated with schizophrenia. Studies of childhood trauma and schizophrenia in low and middle income (LMIC) countries are limited. This study examined the prevalence of childhood traumatic experiences among cases and controls and the relationship between specific and cumulative childhood traumatic experiences and schizophrenia in a sample in South Africa. Data were from the Genomics of Schizophrenia in the South African Xhosa people study. Cases with schizophrenia and matched controls were recruited from provincial hospitals and clinics in the Western and Eastern Cape regions in South Africa. Childhood traumatic experiences were measured using the Childhood Trauma Questionnaire (CTQ). Adjusted logistic regression models estimated associations between individual and cumulative childhood traumatic experiences and schizophrenia. Traumatic experiences were more prevalent among cases than controls. The odds of schizophrenia were 2.44 times higher among those who experienced any trauma than those who reported no traumatic experiences (95% CI 1.77-3.37). The odds of schizophrenia were elevated among those who experienced physical/emotional abuse (OR 1.59, CI 1.28-1.97), neglect (OR 1.39, CI 1.16-1.68), and sexual abuse (OR 1.22, CI 1.03-1.45) compared to those who did not. Cumulative physical/emotional abuse and neglect experiences increased the odds of schizophrenia as a dose-response relationship. Childhood trauma is common in this population. Among many other benefits, interventions to prevent childhood trauma may contribute to a decreasing occurrence of schizophrenia.

Full blood count and white cell differential count reference ranges obtained from a healthy urban South African population residing in the Western Cape of South Africa.

Research has suggested that individuals of African descent have lower white cell and neutrophil counts than Caucasians. These differences could lead to incorrect clinical decisions, and therefore, ethnic-specific reference ranges are required. The Western Cape region of South Africa is uniquely diverse, comprising Caucasian, Mixed Ancestry and those of African descent. The aim of this study was to compare the full blood count and differential counts across the three major ethnic groups residing in this area and to propose appropriate RIs. The study formed part of the international project led by the Committee on Reference Intervals and Decision Limits (C-RIDL), and therefore, the strict guidelines laid out by the committee were followed. Full blood count and differential counts were performed on a Beckman Coulter ACT 5 diff AL analyser within 2-4hours of collection and were reported as mean (standard deviation), 2.5th and 97.5th percentiles. Comparisons were analysed using Spss v25 and Statistica v13, and a P value of<0.05 was considered significant. Reference ranges for Caucasian and Mixed Ancestry individuals were similar while white cell (P=0.016), monocyte (P<0.001), neutrophil (P=0.034) and red cell indices were significantly different amongst the three population groups. There were however no statistical and clinical significant differences between the eosinophil, lymphocyte, red cell and platelet counts across the three groups. In conclusion, subjects of Mixed Ancestry, in this region, have similar reference intervals to those of European descent, while lower white cell and neutrophil counts in Africans have been confirmed.

Sustainable Nepenthes mirabilis facilitated recovery of reducing sugars from grape pomace

Grape pomace (GP) generated from the winery industry is one of the abundant agro-waste in the Western Cape, South Africa and other regions globally. GP contains a significant quantity of holocelluloses that can be converted into fermentable total reducing sugars (TRS). This study reports on the recovery of TRS from GP treated Nepenthes mirabilis digestive fluids for mediated biovalorisation in comparison to a combination of conventional pretreatment methods (hot water pretreatment, dilute acid pretreatment, and cellulase pretreatment) in a single pot system. The recovery of TRS was facilitated while also reducing total residual phenolics (TRPCs) in the samples. Furthermore, powder X-ray diffraction (pXRD) was used to measure the crystallinity index and the functional groups of pre- and post-pre-treated GP were determined using Fourier-transform infrared spectroscopy (FTIR) to ascertain the efficiency of the pre-treatment methods, with quantification of lignin, holocellulose and ash being conducted. Overall, the TRS yield for N. mirabilis pre-treated agro-waste was 951±4.7 mg/L, with biomass having a lower CrI of 33%, and 62% residual lignin content. Furthermore, reduced TRPCs were observed in hydrolysate, suggesting limited inhibitory by-product formation during N. mirabilis pre-treatment.

Language and communication issues in HIV/AIDS intervention management in the South African construction industry

Purpose Effective communication is a key factor in presenting Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) awareness and prevention campaigns, and delivering treatment programmes, particularly in South Africa where different ethnic groups and a diversity of languages and educational attainment levels are encountered. Language is an important element of such communication. The purpose of this paper is to examine the communication effectiveness of AIDS-related intervention messages. Design/methodology/approach Case-based semi-structured interviews, with 42 employees from three construction organisations, and with six telephone counsellors from a service provider, were used to explore language in the HIV/AIDS context in the construction industry in the Western Cape region. Findings Workers’ knowledge about HIV (a key element in prevention and willingness to engage in treatment regimes) tended to align with their level of education. African cultures may inhibit the use of plain language about AIDS. Graphic posters with text in different languages were the most preferred communication media, but need periodic refreshment to remain effective. For toolbox talks and other company presentations, a comprehensive approach to language differences is limited, and appropriate confirmatory feedback loops are not used – the message sent is not always the message received. The recruitment and training processes for service provider counsellors ensure a more comprehensive grasp of HIV knowledge and a more consistent approach to communication. Practical implications Construction organisations should be more careful in their HIV/AIDS campaigns and programmes, ensure better targeting of audiences and pay more nuanced and sensitive attention to language needs, gender differences and cultural contexts with respect to communicating with workers in ways that engage them more fully about HIV/AIDS, stigma and disclosure. Originality/value Communication effectiveness is pivotal in the provision of intervention management by construction firms. Ineffective language and communication processes directly and adversely influence HIV/AIDS intervention management success.

Challenges of Integrated Water Resources Management in the Western Cape Province, South Africa

The increased demand for water and land in South Africa, in particular the Western Cape Province as a consequence of population growth, climate change and economic development has reportedly been accelerated from year to year. The province has been adhering to the Intergrated Water Resources Management (IWRM) which was developed in the Water Indaba of 2009 in order to respond to the joint National and Provincial action towards managing the water resources in the Western Cape Province. At the same time, there is growing empirical evidence that challenges the scientific consensus and the practical implications of implementing IWRM provincially and nationally, although the nature of the implementation challenges may differ in different contexts. Against this background, this paper investigates the nature of the practical challenges to implementing water resource management in the Western Cape region. The study reviewed existing literature on the various issues of IWRM in South Africa; the various basins in the country; the existing measures that the authorities have in place to deal with water resources management issues; the challenges that hinder the progress of their achievements and some suggestions that if considered can improve the current water resources management situations in South Africa. The availability of water and a broader range of water-related issues are identified. The recommended actions for improving the future IWRM are suggested. Challenges to improve the capacity buildings of IWRM related to enabling environment, institutional frameworks and management instruments are verified to contribute to the future directions for efficient problem-solving ability.

South Africa’s winter rainfall region drought: A region in transition?

The Western Cape region of South Africa is a key producing area for South African agriculture, with a strong dependence on austral winter rainfall. The past three years have, however, seen extensive drought impacting this region, with significant impacts on agriculture. In this article, we unpack how the drought unfolded, as well as possibilities in predicting winter rainfall. We consider how drought impacted agriculture, looking in depth at two commodities key to the winter rainfall region agricultural sector – namely, wheat and apples; concluding with a brief discussion of implications for the future.

Group B Streptococcus Serotypes in Pregnant Women From the Western Cape Region of South Africa.

Background: Maternal colonization of Group B streptococci (GBS) during pregnancy is an important risk factor for neonatal morbidity and mortality. The aim of this study was to determine the prevalence and serotype distribution of GBS isolated from a cohort of pregnant women in the Western Cape, South Africa.Methods: Two ano-vaginal swabs were collected from 301 women at 28–37 weeks of gestation. Participants were recruited from four different antenatal clinics in the Western Cape, South Africa. GBS were detected by culture and PCR and serotypes confirmed by latex agglutination tests. Antibiotic sensitivity was performed using disc diffusion.Results: The GBS colonization rate was 16.6%. Serotype distribution revealed serotype V as the predominant serotype (66.67%) followed by serotype III (21.05%). Serotypes Ia, II, IV, and IX constituted 1.75% each and 3 GBS isolates were non-typeable. Serotype V demonstrated resistance to most of the antibiotics tested, while serotype III demonstrated better susceptibility, except for tetracycline. No significant differences were observed for GBS colonization or serotype distribution according to HIV status.Conclusion: Predominating serotypes differed from those previously reported from other regions in South Africa. Global surveillance of serotype distribution plays an important role in informing vaccine development and antibiotic prophylaxis.

Growth-stage and temperature influence glyphosate resistance in Conyza bonariensis (L.) Cronquist

Glyphosate, currently the world's most extensively used herbicide was on the market for more than 20 years since its introduction in 1975 without reported evolution of resistant weed cases. Glyphosate is the only reported herbicide to inhibit 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), and endogenous accumulation of shikimic acid has been used as a biomarker for the herbicide's activity in plants after spraying. Increased levels of shikimic acid indicate sensitivity or injury while a lack or limited accumulation of shikimic acid shows resistance to glyphosate. Conyza bonariensis seed germinates in flushes in South Africa and its emergence is staggered throughout the year under conducive temperature conditions. This variability in growth stages in the same field poses a challenge in chemical control. Glyphosate herbicide efficacy is affected by environmental conditions, particularly temperature. A glyphosate resistance screening study was carried out based on reports from farmers that C. bonariensis has become increasingly difficult to control especially in conservation tillage systems. This study has confirmed the occurrence of glyphosate-resistant C. bonariensis (hairy fleabane) cases in the western and southern Cape regions of South Africa. A glasshouse screening experiment of 24 biotypes indicates resistance levels ranging from 0.6 to 26.9-fold, with GR50 values of up to 3908.42 g.ae.ha−1 being reported in a population collected from a vineyard in the Piketberg district of the western Cape. The influence of growth stage and temperature on glyphosate resistance in hairy fleabane was evaluated by using a shikimate assay. Results from this study have shown that response of hairy fleabane to glyphosate is influenced by the phenological stage, with sensitivity or injury decreasing with growth stage. The significant statistical tests verified the dependence of the shikimate pathway on temperature, with more shikimic acid accumulating at 15 °C compared to 27 °C across all biotypes, regardless of origin and glyphosate tolerance status. More tolerance to the herbicide was demonstrated under warm temperature conditions. Possible outcomes of applying glyphosate at the bolting stage and under warm temperature conditions are escapes and no control of susceptible and resistant plants, respectively.

Anthropogenic influence on the drivers of the Western Cape drought 2015–2017

In the period 2015–2017, the Western Cape region has suffered from three consecutive years of below average rainfall—leading to a prolonged drought and acute water shortages, most prominently in the city of Cape Town. After testing that the precipitation deficit is the primary driver behind the reduced surface water availability, we undertake a multi-method attribution analysis for the meteorological drought, defined in terms of a deficit in the 3 years running mean precipitation averaged over the Western Cape area. The exact estimate of the return time of the event is sensitive to the number of stations whose data is incorporated in the analysis but the rarity of the event is unquestionable, with a return time of more than a hundred years. Synthesising the results from five different large model ensembles as well as observed data gives a significant increase by a factor of three (95% confidence interval 1.5–6) of such a drought to occur because of anthropogenic climate change. All the model results further suggest that this trend will continue with future global warming. These results are in line with physical understanding of the effect of climate change at these latitudes and highlights that measures to improve Cape Town’s resilience to future droughts are an adaptation priority.

Patterns of copy number alterations in primary breast tumors of South African patients and their impact on functional cellular pathways.

Breast cancer is the most common and the leading cause of female mortality among South African (SA) women. Several non‑biological and biological risk factors may be attributed to their observed high mortality rate; however, the molecular profiles associated with their breast tumors are poorly characterized. The present study examined the patterns of genome-wide copy number alterations (CNAs) and their potential impact on functional cellular pathways targeted by cancer driver genes in patients with breast cancer from the Western Cape region of SA. Array-comparative genomic hybridization analysis, performed in 28 cases of invasive breast cancer, revealed a mean number of 8.68±6.18 CNAs per case, affecting primarily the Xp22.3 and 6p21-p25 cytobands (57.14% of the cases), followed by 19p13.3-p13.11 (35.7%), 2p25.3-p24.3, 4p16.3-p15.3, 8q11.1-q24.3 and 16 p13.3-p11.2 (32.14%). Functional enrichment analysis of genes and microRNA targets mapped in these affected cytobands revealed critical cancer-associated pathways, including fatty acid biosynthesis and metabolism, extracellular matrix-receptor interaction, hippo and tumor protein p53 signaling pathways, which are regulated by known cancer genes, including CCND1, CDKN1A, MAPK1, MDM2, TP53 and SMAD2. An inverse correlation was observed among the number of CNAs and tumor size and grade; CNAs on the 4p and 6p cytobands were also inversely correlated with tumor grade. No association was observed in the number of CNAs and/or the affected cytobands and the different ethnic groups of the SA patients, indicating that their tumor genome is affected by CNAs, irrespectively of their genetic descent. Additional genomic tumor profiling in SA and other Sub-Saharan African patients with breast cancer is required to determine the associations of the CNAs observed with prognosis and clinical outcome.

The Invasive Vespidae in South Africa: Potential Management Strategies and Current Status

Vespula germanica (Fabricius) and Polistes dominula (Christ) are known to represent a significant threat to the biodiversity of ecosystems that they invade. Following their discovery in South Africa, there has been a lag in investigations into the presence and spread of both invasive wasp species in South Africa with limited action taken to address their expansion. Recent research indicated that populations of both species are still restricted to the Western Cape Region, where the Cape Fold Mountain Belt seems to serve as a barrier to further spread to the rest of South Africa. The limited distribution range creates a favourable scenario for management efforts and, if acted on rapidly, increases the possibility of successful control. Various control methods, including mechanical, chemical and biological control have been developed and implemented internationally in an effort to curb population expansion of social wasps. These methods, together with a summary of the initiatives that have been launched loca...

Citizenship: A core motive for South African university student volunteers

Research suggests that the desire to help others (value) and learning interpersonal skills (understanding) are core reasons for student volunteerism. Interpretations of such reports often minimise the role of contextual factors in shaping volunteer motives. This study considers the policy and institutional contexts that advocate for community engagement and social impact in South African higher education as a contributing factor in shaping student perceptions on reasons for volunteering. This article draws on student volunteers’ responses to an open-ended question exploring their volunteer motives. Active student volunteers (N = 70) were recruited from six community projects across three South African universities in the Western Cape region. The findings suggest that citizenship together with the value and understanding functions are core motives for volunteering among South African university students. These accounts of student volunteer motives posit strong links to contextual factors; a phenomenon that holds significant implications for policy makers.