Despite the extensive scientific data available on the impact of meteorological and heliogeophysical factors on the health and physiological parameters of the organism, the ecological role and biological nature of the mechanisms of their interaction remain unclear. The need to choose an integrated approach to the study of the Space–Earth–Human system is obvious and justified because it is based on the idea of using modern technologies and channels for obtaining and disseminating information about the impact of space weather, variability of the atmosphere, electromagnetic and gravitational fields, anthropogenic pollution and other environmental parameters that requires effective and rapid solution. It has been established that the body’s response to various stressful influences is largely determined by the ratio of the tone of the sympathetic and parasympathetic divisions of the autonomic nervous system. It is the autonomic nervous system (ANS) and, above all, its sympathetic division that plays a special role in the formation of adaptive reactions of the body, the development of meteorological reactions, i.e. the autonomic nervous system is the primary site of meteorological influences that cause shifts in its balance. Determination of vegetative status and direction of vegetative activity in boys’ organism was carried out by means of functional and vegetative diagnostics by V. Makats’ method. We examined 151 boys, including 49 boys aged 7–11 years and 102 — aged 12–15 years, FVD was carried out in the morning at 10.00–11.00. Since the state of the autonomic nervous system is decisive in the development of meteotropic reactions, the data of the study of vegetative tone in sunny and cloudy weather under the combined influence of heliomagnetic storms (HMS) were analysed, favourable and unfavourable weather conditions for the body were determined and the state of adaptive health of the examined children was determined. It was found that under the influence of heliometeorological factors on the organism of practically healthy young boys, agerelated peculiarities of meteorological variability are observed. The most sensitive to changes in weather and climatic conditions under the combined influence of HMS was the group of primary school age boys (PSA) aged 7–11 years, who showed maximum deviations in the activity of functional systems from the age norm, and the least sensitive was the group of boys aged 12–15 years. When analysing the influence of changes in weather conditions on the body of boys by the vegetative coefficient (kV), it was found that at the norm of kAv 0.95–1.05, it increased maximally when exposed to sunny weather and amounted to 1.12 in the revealed state of vegetative balance. In a healthy organism, changes in physiological processes and functional activity of systems under the influence of such a factor as changes in boys’ PSA, which indicates a pronounced sympathicotonia, and in boys’ ASA 0.93, respectively, which indicates a slight parasympathicotonia. The effects of cloudy weather on the body in both groups, even with the combined effect of HMB, are easily compensated for, and a special role in this belongs to the autonomic nervous system, whose activity ensures an adequate response of the body to the effects of environmental factors. Knowledge about meteosensitivity and meteorological reactions is necessary for the development of both preventive and therapeutic measures aimed at increasing nonspecific resistance and adaptation mechanisms of the body, normalising the function of organs and systems as a basis for normal reactions to adverse environmental changes. Environmental factors, including meteorological factors, are directly related to human life and health. Each of the meteorological elements has its own biological significance. This raises the question of the impact of solar activity, weather, atmospheric conditions, and, above all, anthropogenic pollution and other environmental parameters on human health, which naturally requires a quantitative approach to risk assessment and the development of necessary management decisions.