A spherical thin-walled stainless steel water tank without reinforced tie ribs has been designed to address the issues of easy fracture and corrosion of the ribs, difficulty in maintenance and cleaning, and short service life exposed during the use of thin-walled stainless steel water tanks with reinforced tie ribs. Firstly, an analytical model of a flat steel thin-walled water tank without reinforced tie ribs was established and subjected to static analysis under water pressure. The deformation and stress distribution patterns of the side molded plate of the flat box were obtained. Secondly, a spherical non ribbed thin-walled stainless steel water tank structure was designed with circular cross-section under different box bulge parameters, and its mechanical response characteristics under water pressure load were analyzed. A strengthening scheme was designed for the bottom box molded plate. Once again, optimize the combination design of the box scheme and the reinforcement scheme, and analyze their static, thermodynamic, and thermal solid coupling performance. Finally, the Latin Hypercube Sampling method was used to generate experimental design samples, and a response surface approximation model of a spherical thin-walled stainless steel water tank without reinforced tie ribs was constructed. The wall thickness of the box molded plate, skeleton, and reinforcement were used as design variables, and the maximum deformation and maximum equivalent stress were used as constraints. The lightweight design was carried out with the goal of minimizing mass. The research results indicate that the design program and parameter selection method for spherical thin-walled stainless steel water tanks without reinforced tie ribs proposed in the article are efficient and feasible, and can provide technical reference and theoretical support for the layout and overall optimization design of non ribbed thin-walled stainless steel water tank structures.