Abstract For an air staged combustion boiler, the rational organization of jets to form closing-to-wall film using as little air as possible plays a key role in resolving the high temperature corrosion problems. In this work, a comprehensive computational fluid dynamics (CFD) model including hydrodynamics and coal combustion is established for a 660 MW opposed wall fired boiler. Based on the grid independence and model validation, the flow field, temperature profile, and species concentration are predicted, and the influences of the structure of nozzles and the operation parameter of jets are further evaluated. The results show that the corrosion area of the side wall is dependent on the jet projection velocity and nozzle structures. The increase of the jet velocity does not always have an active influence on the reduction of corrosive area. Only increasing the nozzle diameter does not always have a positive impact on the improvement of the corrosion. The increase of the jet inclination angle can extend the jet trajectory, contributing to increase the oxygen coverage area. Reasonably adjusting the jet inclination angle of each layer can obtain the lower corrosion area. The increase of jet row number leads to a decrease in the spacing between rows, which enables the downstream jet to penetrate deeper into the cross stream. By increasing the number of jet layers and reducing the jet velocity of each layer, the lowest corrosion area can be obtained.