In this paper, a sample voltage dead-beat control based on differentiative voltage prediction (DVP) and switching-cycle extension (SCE) is presented to achieve optimal transient response for DC-DC converters under discontinuous conduction mode (DCM) operation. Firstly, to improve load transient response, a DVP method is proposed to estimate the load. With the estimated load, the controller realizes load current feedforward and thus improves the transient response with a wide load range. Secondly, an SCE strategy is proposed to enlarge the output current range and output voltage slew rate, both of which have limited value under conventional digital pulse width modulation (DPWM). When the output current reaches the limited value, the proposed strategy increases the switching cycle to enlarge the current range without losing DCM operation. Finally, combining DVP with SCE, the converter not only achieves optimal response in large signal transients, but also doubles the load range in DCM operation.