Viscosity B-coefficients Of Transfer Research Articles

A study of enhancing the solubility of streptomycin sulphate in sorbitol using volumetric, acoustic and viscometric properties

The various molecular interactions present between streptomycin sulphate and sorbitol were evaluated using density (ρ), speed of sound (u) and viscosity (η) studies. All these studies have been obtained at different temperatures (300.15, 305.15, 310.15 ad 315.15) K and at 0.1 MPa pressure. The values obtained from these studies have been utilized to calculate the various thermodynamic parameters such as apparent molar volume (ΦV), apparent molar isentropic compression (ΦK), partial molar volume (ΦVo), partial molar isentropic compression (ΦKo), partial molar expansibility (ΦEo) of solute for SMS in various solutions of sorbitol. The data obtained from viscosity studies have been utilized to determine Falkenhagen coefficient (A), Jones- Dole coefficient (B), dB/dT and viscosity B-coefficient of transfer (Btr). A complete discernment into the physicochemical interactions present in the studied system have been redeemed through the scrutiny of above calculated parameters.

Molecular interactions of diphenyldiselenide in DMSO and varied weight % of ethanol in DMSO solvent media at different compositions and temperatures (288.15 to 318.15)K

In the present work, volumetric, rheological, and thermodynamic analysis has been carried out for varied compositions of diphenyldiselenide in dimethyl sulfoxide/(5–25)% w/w of ethanol in dimethyl sulfoxide at seven distinct temperatures varying from 288.15 K to 318.15 K and ambient pressure (0.1 MPa). Through the acquired density data, the volumetric parameters such as apparent molar volume (Vϕ), limiting apparent molar volume (Voϕ), transfer molar volumes (Vϕ,tro), limiting apparent molar expansivity (Eϕo), thermal expansion coefficient (α), and Hepler’s constant (2c) were estimated. By the use of viscosity data, (viscosity A and B coefficients), viscosity B-coefficient of transfer (Btr), change in viscosity B-coefficient with temperature and thermodynamic properties (Δμ10,Δμ20, ΔH20 and TΔS20) were inferred. These parameters have aided in scrutinizing the various feasible interactions existing in the studied systems. From the explored results, we predicted that ion-hydrophillic / hydrophilic-hydrophillic interactions are predominant in the studied systems. Furthermore, through the positive sign of Hepler’s constant and negative sign of change in viscosity B-coefficient with temperature values, we have inferred that diphenyldiselenide behaves as structure maker in dimethyl sulfoxide/(5–25)% w/w of ethanol in dimethyl sulfoxide.

Volumetric, acoustic and viscometric studies of solute-solute and solute-solvent interactions of glycine and its peptides in aqueous solutions of an antidepressant drug at different temperatures

From the density (ρ), speed of sound (u) and viscosity (η) measurements, the interactions of glycine, glycylglycine and glycylglycylglycine with antidepressant drug, nortriptyline hydrochloride have been investigated in aqueous medium at temperatures, T = (293.15–313.15) K and experimental pressure p = 0.1 MPa. From the experimental density measurements, apparent molar volume (VΦ), limiting apparent molar volume (VoΦ) and partial molar volumes of transfer (VoΦ,tr) have been determined for various solutions of glycine, glycylglycine and glycylglycylglycine in aqueous nortriptyline hydrochloride. In addition, using speed of sound data, apparent molar isentropic compression (Ks,Φ), limiting apparent molar isentropic compression (Kos,Φ) and partial molar isentropic compression of transfer (Kos,Φ,tr) have been calculated. Pair and triplet interaction coefficients are also determined from VoΦ,tr values using McMillan-Mayer theory. Further, apparent molar expansibility (EoΦ) and Hepler's constant values ∂EoΦ∂TP have been evaluated to assist the interpretations earned from the volumetric and acoustic analysis. The viscosity coefficients A and B, viscosity B-coefficient of transfer (Btr) and temperature derivative of B-coefficients (dB/dT) have been determined from viscosity data. The results were interpreted in terms of different kinds of intermolecular interactions present in the ternary systems (amino acid/peptides + water + nortriptyline hydrochloride) through a cosphere overlap model. The Hepler’s constant and temperature derivative of B-coefficients (dB/dT) confirms the structure breaking nature of the solute.

Thermophysical studies of protonated and deprotonated glycine in aqueous sodium acetate buffer solutions at different temperatures

Interactions of glycine in water and in (0.10, 0.50 and 1.00) aqueous sodium acetate buffer solutions of pH (1.00 and 12.40) have been investigated at different temperatures, T/K = (298.15-318.15). Densities, and viscosities, of glycine in water and in aqueous sodium acetate buffer solutions have been measured. The obtained density data have been used to calculate apparent molar volume, , limiting partial molar volume, , limiting partial molar volumes of transfer, . Viscosity B-coefficient, viscosity B-coefficient of transfer, , Activation free energies per mole of the solute, and solvent, have been calculated from viscosity data. Further, second order derivative of partial molar expansion coefficient and dependence of coefficients on temperature is useful in measuring the structure making and breaking behavior of solute in these systems. Pair and triplet interaction coefficients for both the properties were also calculated. Thus, the results obtained from volumetric and viscometric studies are of considerable importance to identify different type of interactions (i.e. H-bonding, van der Waal’s interactions)in these systems.

Physicochemical studies of synthesized biscoumarin [3,3-(phenylmethylene)bis(4-hydroxy-2H-chromen-2-one)] in DMSO and various percentage compositions of ethanol in DMSO from 288.15 to 313.15 K

Density, speed of sound and viscosity for varying concentrations of 3,3-(phenylmethylene)bis(4-hydroxy-2H-chromen-2-one) in DMSO and solvent media containing (5, 10, 15, 20, 25)% w/w of ethanol in DMSO have been measured. These properties have been deliberated over a wide range of temperatures ranging from 288.15 K to 313.15 K and at p = 0.1 MPa. From the experimental data, different derived parameters like apparent molar volume (Vϕ), limiting apparent molar volume (V0ϕ), apparent molar isentropic compression (Kϕ,s), limiting apparent isentropic compression (K0ϕ,s), transfer volumes, limiting apparent molar expansibility (E0ϕ), coefficient of thermal expansion (α), Hepler's constant, viscosity coefficients (A and B), viscosity B-coefficient of transfer and dB/dT values have been determined. Further, the results have been expounded in terms of solute-solute and solute-solvent interactions and structure-making ability of solute molecules in different solvent systems of study.

Physicochemical studies on vitamins B1, B3, B6 and C in aqueous magnesium chloride solutions at different temperatures (288.15–318.15) K and at pressure (101.3) kPa

Vitamins are the precursors of many coenzymes essential for biocatalysts and their deficiency leads to diseases in masses. The vitamins are very fragile and can easily be destroyed with change external atmosphere. Electrolytes are inherent constituents of cytoplasm and are required in variety of biochemical functions. The interactions occurring between, solute-cosolute and solvent can be inferenced and interpreted from thermodynamic and transport studies effectively which will help in interpreting the mechanism of vitamins in solution phase. In the present study apparent molar volume ϕV, and viscosity B-coefficient B, have been determined for l-ascorbic acid (Vit.C), nicotinic acid (Vit.B3), thiamine hydrochloride (HCl salt of Vit. B1) and pyridoxine hydrochloride (HCl salt of Vit. B6) in aqueous magnesium chloride solutions (mB = 0.1 to 0.5 mol∙kg−1) over the temperature range (288.15–318.15) K at pressure (101.3) kPa. The partial molar volume of transfer, ∆trϕVo, and viscosity B-coefficient of transfer, ∆trB, for these compounds from water to aqueous solutions of magnesium chloride have been determined from the corresponding data. First (∂ϕVo/ ∂T) P and second (∂2ϕVo/ ∂T2)P, derivative of ϕVo and dB/dT, values have been calculated. B/ϕVo ratio, activation free energy of viscous flow of vitamins ∆μ2o#, and other parameters have also been calculated. Both volumetric and viscometric studies suggest the presence of complex interactions at lower concentrations, but the role of cosolute becomes decisive at higher concentrations. The dB/dT values and activation parameters (∆S2o#, ∆H2o#) values suggest that l-ascorbic acid, thiamine hydrochloride and pyridoxine hydrochloride show bond making tendencies with magnesium chloride while nicotinic acid shows comparatively less affinity with magnesium chloride.

Molecular interactions studies of doxycycline hyclate in water, aqueous L-phenylalanine and glycyl glycine at different temperatures by using volumetric, ultrasonic and viscometric parameters

The density, sound velocity and viscosity of doxycycline hyclate in water, aqueous solution of L-phenylalanine and aqueous solution of glycyl glycine have been determined at different temperatures (305.15, 310.15, 315.15 and 320.15) K. The calculated values of partial molar volume (V_ϕ^o), standard partial molar volume of transfer (〖Δ_tr V〗_ϕ^o), partial molar adiabatic compressibility (κ_(ϕ,s)^o) and partial molar adiabatic compressibility of transfer (〖Δ_tr κ〗_(ϕ,s)^o) for doxycycline hyclate in water, aqueous solution of L-phenylalanine and aqueous solution of glycyl glycine infer the dominance of ion-hydrophilic interactions over hydrophobic-hydrophobic interactions. The Jones-Dole viscosity B-coefficient, viscosity B-coefficient of transfer (ΔtrB), free energy of activation of viscous flow per mole of pure solvent (〖Δμ〗_1^(o*)) and solute (〖Δμ〗_2^(o*) ), respectively, activation entropy (〖ΔS〗_2^(o*)) and activation enthalpy (〖ΔH〗_2^(o*)) of doxycycline hyclate in water, aqueous solution of L-phenylalanine and aqueous solution of glycyl glycine also have been calculated using viscosity data. The structure making and breaking behaviour of doxycycline hyclate in water, aqueous solution of L-phenylalanine and aqueous solution of glycyl glycine are obtained from the values of Hepler’s constant i.e.((δ^2 V_ϕ^o)/(δT^2 )) and (dB/dT). The presence and absence of caging effect has been studied with the help of partial molar adiabatic expansibility (E_ϕ^o). The isobaric thermal expansion coefficient (α^o= (E_ϕ^o)/(V_ϕ^o )), intermolecular free length and acoustic impedance for doxycycline hyclate in water, aqueous solution of L-phenylalanine and aqueous solution of glycyl glycine also have been determined.

Apparent molar volume and coefficients of Jones-Dole equation for the evaluation of ion- solvent interactions of barium chloride in aqueous 1, 4-dioxane and ethylene glycol solutions at T= (298.15 K to 313.15) K and at atmospheric pressure

The viscosity and density of barium chloride have been measured at T= (298.15-313.15) K in aqueous solutions of 1, 4-Dioxane (1,4-DO) and Ethylene glycol (EG). Jones–Dole equation was used to analyze the viscosity data. The apparent molar volume, V_ϕ limiting apparent molar volume, V_ϕ^0 are calculated from the density data. Limiting apparent molar expansibilities, E_ϕ^0 have been used to describe the temperture dependency of V_ϕ^0. The standard volume of transfer, ΔtV_ϕ^0 and viscosity B-coefficient of transfer, ΔtB of barium chloride from water to aqueous 1, 4-DO and EG solutions were systematizing the different types of interactions in the given solutions. The structure making and breaking capacity of solute in solutions was interpreted with the help of Helper equation. The positive value of (∂2V_ϕ^0/∂T2)p suggests the structure making nature for BaCl2 in given solution. It is observed that Friedman-Krishnan co-sphere model explains the increase in the transfer volume of BaCl2 with an increase in 1,4-DO and EG concentrations. The activation parameters of the viscous flow of the given solutions were calculated and interpreted using transition state theory.

Molecular Interactions of Non-Steroid Anti-Inflammatory Drug Dolonex in Aqueous Solutions of L-Alanine/L-Valine at Different Temperatures: Viscometric Approach

The viscosities of aqueous solutions of L-alanine and L-valine with non-steroid anti-inflammatory drug dolonex (0.020, 0.040, 0.060 mol kg–1) have been measured at different temperatures (293.15–313.15 K) and at atmospheric pressure. On the basis of experimental results Jones–Dole coefficient-B, viscosity B-coefficient of transfer, activation parameters i.e., free energy of activation of viscous flow per mole of solvent $$\Delta \mu _{2}^{{^\circ \# }}$$ and per mole of solute $$\Delta \mu _{1}^{{^\circ \# }}$$ were determined. The obtained results were discussed in terms of solute–solvent interactions in these solutions. Moreover, structure breaker tendency of solute molecules were obtained by measuring temperature derivative of viscosity B-coefficient.

Viscometric and Conductometric Studies of Doxycycline Hyclate in Water, Aqueous Glycine and L-Alanine Solutions at Different Temperatures

To investigate the behaviour of doxycycline hyclate in water, aqueous glycine and aqueous L-alanine solutions, the viscometric and conductometric studies have been conducted at different temperatures. Viscosity data has been used to derive the Jones-Dole viscosity B-coefficient, temperature derivative of B-coefficient (dB/dT), viscosity B-coefficient of transfer (ΔtrB), free energy of activation of viscous flow per mole of solvent (Δμ1 o*) and solute (Δμ2o*) respectively, activation entropy (ΔS2o*) and activation enthalpy (ΔH2o*). Conductance data has been used to compute Walden product (Λm oηo) and temperature coefficient of Walden product (dΛmoηo/dT) for doxycycline hyclate in water, and in aqueous glycine and aqueous L-alanine solution. The positive values of B-coefficient, ΔtrB indicate the prevailing of hydrophilic-ionic interactions in the systems under examination. The negative values of dB/dT and positive values of temperature coefficient of Walden product infer structure maker tendency of doxycycline hyclate in water, and in aqueous glycine and aqueous L-alanine solution. Transfer energy parameters indicate the breaking of intermolecular bonds in transition state which means that formation of activated complex is unfavourable

Effect of 1-Octyl-3-Methylimidazolium Salicylate as an Active Pharmaceutical Ingredient (API-IL) on the Thermodynamic Behavior of Aqueous Glycine Solutions at T= 298.15 K

Background: The thermophysical properties of 1-octyl-3-methylimidazolium salicylate as an active pharmaceutical ingredient based on ionic liquid have been investigated in the presence of aqueous solutions of glycine. Therefore, the scope of this article was to determine these properties by measuring the densities, speeds of sound, viscosities, electrical conductances and refractive indices for ternary (glycine + 1-octyl-3-methylimidazolium salicylate + water) soloutions at T = 298.15 K. Methods: A commercial density and speed of sound measurement apparatus was used to measure the density and speed of sound data. Viscosities, electrical conductivities and refractive indices of the studied solutions were measured using digital viscometer, conductivity meter and refractometer, respectively. Results: Variety of properties such as partial molar volume of transfer ∆traV0ϕ, partial molar isentropic compressibility of transfer ∆traK0ϕ, viscosity B-coefficients of transfer ∆traB, ion association constants (KA) and molar refraction RD were determined to investigate the solute-solute and solute-solvent interactions in these systems. Conclusion: The positive values of transfer properties including partial molar volume of transfer (∆traV0ϕ), partial molar isentropic compressibility of transfer (∆traK0ϕ), and viscosity B-coefficients of transfer (∆traB) indicated that in these systems, the ion-polar and polar-polar interactions are dominant. The calculated hydration number showed that dehydration of glycine occurs in presence of this ionic liquid.

Drug Delivery Systems: Study of Inclusion Complex Formation between Methylxanthines and Cyclodextrins and Their Thermodynamic and Transport Properties

This paper presents an analysis of the molecular mechanisms involved in the formation of inclusion complexes together with some structural interpretation of drug–carrier molecule interactions in aqueous multicomponent systems comprising methylxanthines and cyclodextrins. The determination of apparent partial molar volumes () from experimental density measurements, both for binary and ternary aqueous solutions of cyclodextrins and methylxanthines, was performed at low concentration range to be consistent with their therapeutic uses in the drug-releasing field. The estimation of the equilibrium constant for inclusion complexes of 1:1 stoichiometry was done through the mathematical modelling of this apparent molar property. The examination of the volume changes offered information about the driving forces for the insertion of the xanthine into the cyclodextrin molecule. The analysis on the volumes of transfer, Δ, and the viscosity B-coefficients of transfer, ΔB, for the xanthine from water to the different aqueous solutions of cyclodextrin allowed evaluating the possible interactions between aqueous solutes and/or solute–solvent interactions occurring in the solution. Mutual diffusion coefficients for binary, and ternary mixtures composed by xanthine, cyclodextrin, and water were measured with the Taylor dispersion technique. The behavior diffusion of these multicomponent systems and the coupled flows occurring in the solution were analyzed in order to understand the probable interactions between cyclodextrin–xanthine by estimating their association constants and leading to clearer insight of these systems structure. The measurements were performed at the standard (298.15 ± 0.01) K and physiological (310.15 ± 0.01) K temperatures.

Thermodynamic Study of L-alanine in Aqueous Solutions of 1-Hexyl-3-Methylimidazolium Ibuprofenate as an Active Pharmaceutical Ingredient Ionic Liquid (API-IL)

The present work reported density, viscosity, speed of sound, electrical conductivity and refractive index data of L-alanine in the aqueous solutions of 1-hexyl-3-methylimidazolium ibuprofenate at T= 298.15 K. Using the measured data, partial molar volume of transfer ( ), partial molar isentropic compressibility of transfer ( ), viscosity B-coefficient of transfer (∆traB), ion association constant (KA) and molar refraction (RD) quantities were calculated. The obtained parameters provide the information about the solvation properties of aqueous solutions of L-alanine in the presence of [HMIm][Ibu]. The positive values of , and ∆traB are indicative of the ion-polar and polar-polar interactions between [HMIm][Ibu] and L-alanine. In addition, decreeing the KA values with addition of L-alanine to the [HMIm][Ibu] solutions suggests that the ion pair formation don’t proceed spontaneously at higher concentration of amino acid.

Study of interactions between l-alanine and 1-octyl-3-methylimidazolium salicylate or 1-octyl-3-methylimidazolium ibuprofenate using the thermophysical properties at T = 298.15 K

The effect of 1‑octyl‑3‑methylimidazolium salicylate, [OMIm][Sal] and 1‑octyl‑3‑methylimidazolium ibuprofenate, [OMIm][Ibu] as active pharmaceutical ingredient ionic liquids (API-ILs) on the solvation properties of l-alanine in aqueous media have been investigated by thermophysical properties determination. The partial molar volume of transfer (ΔtraVϕ0), partial molar isentropic compressibility of transfer (Δtraκϕ0), viscosity B-coefficient of transfer (∆traB), ion association constant (KA) and molar refraction (RD) quantities have been calculated using the measured density, speed of sound, viscosity, electrical conductance and refractive index data. The results showed that the ion-polar and polar-polar interactions between API-ILs and l-alanine are dominant.

Thermophysical Properties of 1-Hexyl-3-methylimidazolium Salicylate as an Active Pharmaceutical Ingredient Ionic Liquid (API-IL) in Aqueous Solutions of Glycine and l-Alanine

The effect of 1-hexyl-3-methylimidazolium salicylate, [HMIm][Sal] as an ionic liquid form of active pharmaceutical ingredient (API-IL) on the thermodynamic behavior of two simple amino acids, glycine and l-alanine have been investigated. The densities, speeds of sound, viscosities, and refractive indices of the amino acids in the mixtures of ([HMIm][Sal] + water) have been determined at T = 298.15 K. Moreover, the electrical conductivities of the studied API-IL in water and aqueous mixtures of the amino acids have been calculated using the measured specific conductivities. The measured data were utilized to compute the partial molar volume of transfer (ΔtraVϕ0), partial molar isentropic compressibility of transfer (Δtraκϕ0), viscosity B-coefficient of transfer (ΔtraB), ion association constant (KA), and molar refraction (RD) quantities. The increase in the positive values of ΔtraVϕ0, Δtraκϕ0 and ΔtraB with an increase in the API-IL concentration indicates that the ion–polar and polar–polar interactions be...

Molecular Interactions in L-threonine Aqueous-Lactose Solutions at (293.15–313.15) K on Viscometric Data

Viscosity measurements of L-threonine in the range (0.025–0.2) mol kg–1 in various aqueous-lactose solutions (0–6 wt % of lactose in water) have been carried out at temperatures (293.15–313.15) K. Jones–Dole coefficients, viscosity B-coefficients of transfer, Btr, variation of B with temperature, dB/dT and solvation behavior, B/ $$V_{\phi }^{^\circ }$$ of L-threonine have been obtained. Further, the free energy of activation of viscous flow per mole of solvent, as well as per mole of solute, along with activation enthalpy, and activation entropy has also been evaluated. The results have been interpreted in terms of various molecular interactions prevalent in these systems and moreover, it has been seen that the L-threonine acts as structure maker in all studied solutions.

Volumetric, acoustic and viscometric studies of l-histidine in aqueous solutions of non-steroid anti-inflammatory drug ketorolac tromethamine at different temperatures

In this investigation density, speed of sound and viscosity of l-histidine (0.015–0.135) molkg−1 in aqueous ketorolac tromethamine solutions (0.1–0.7) molkg−1 at various temperatures (293.15, 298.15, 303.15, 308.15 and 308.15) K and at atmospheric pressure were studied. These data were further used to calculate apparent molar volume, VΦ, limiting apparent molar volume, V°Φ, limiting apparent molar volume of transfer, V°Φ,tr, apparent molar isentropic compression, KΦ,S, limiting molar isentropic compression, K°Φ,S, limiting apparent molar isentropic compression of transfer, K°Φ,S,tr, hydration number, nH, Jones-Dole coefficient-B, B, viscosity B-coefficients of transfer, Btr and the activation parameters, ∆μ°#1 and ∆μ°#2. The results obtained from all these thermodynamic parameters were discussed in terms of solute-solute interactions and solute-solvent interactions on the basis of co-sphere overlap model and the transition state theory.

Structure making behaviour of L-histidine in aqueous solutions of ampicillin sodium at different temperatures: Using physicochemical methods

Experimentally determined values of density (ρ), speed of sound (u) and viscosity (η) have been used to investigate solute-solvent interactions of L-histidine in aqueous ampicillin sodium (an antibacterial drug) solutions at different concentrations (0.035, 0.055, 0.075 and 0.095)molkg−1, over a wide range of temperatures (293.15, 298.15, 303.15, 308.15 and 313.15)K and at atmospheric pressure. The experimentally determined density (ρ) data has been used to obtain various parameters, for instance: apparent molar volume (VΦ), limiting apparent molar volume (VoΦ), limiting apparent molar volume of transfer (VoΦ,tr), limiting molar expansivity (EoΦ) and hydration number (nH). The speed of sound (u) data helps to enumerate apparent molar isentropic compression (KΦ,S), limiting molar isentropic compression (KoΦ,S), limiting apparent molar isentropic compression of transfer (KoΦ,S,tr) and hydration number (nH) i.e., the number of water molecules hydrated to the amino acid. Relative viscosity (ηr), Jones-Dole coefficient-B (B) and viscosity B-coefficients of transfer (Btr) were calculated from viscosity (η) data. The results obtained from this data, showed the existence of physico-chemical interactions, (i.e., hydrophilic-ionic and hydrophilic-hydrophilic) in ampicillin sodium L-histidine solutions. The structure making behaviour of L-histidine in aqueous ampicillin sodium solution was studied in terms of Hepler’s constant ∂2VΦo∂T2P, coefficient of thermal expansion (α) and temperature derivative of B-coefficient (dB/dT).

Volumetric, Compressibility, Taste Behavior and Viscometric Studies of Methionine with Some Saccharides in Aqueous Medium at Different Temperatures

The density, speed of sound and viscosity of methionine (0.025–0.200 mol·kg−1) in water and some aqueous saccharides (0.1 mol·dm−3 glucose, 0.1 mol·dm−3 sucrose and 0.1 mol·dm−3 lactose) have been measured at temperatures of (293.15, 298.15, 303.15, 308.15 and 313.15) K. Using the experimental values of density and speed of sound, apparent molar volume, limiting apparent molar volume, transfer volume, as well as apparent molar isentropic compressibility, limiting apparent molar isentropic compressibility, transfer compressibility, partial molar expansibility, coefficient of thermal expansion, hydration number and taste behavior have been obtained. Jones–Dole coefficient, viscosity B-coefficients of transfer and variation of B with temperature have also been obtained from viscosity data. The Gibbs energy of activation of viscous flow per mole of solvent as well as per mole of solute, along with other activation parameters, were evaluated employing Feakin’s transition state theory.

Volumetric, Acoustic and Transport Properties of Metformin Hydrochloride Drug in Aqueous d-Glucose Solutions at T = (298.15–318.15) K

Apparent molar volumes, apparent molar adiabatic compressibilities and viscosity B-coefficients for metformin hydrochloride in aqueous d-glucose solutions were determined from solution densities, sound velocities and viscosities measured at T = (298.15–318.15) K and at pressure p = 101 kPa as a function of the metformin hydrochloride concentrations. The standard partial molar volumes ( $$ \phi_{V}^{0} $$ ) and slopes ( $$ S_{V}^{*} $$ ) obtained from the Masson equation were interpreted in terms of solute–solvent and solute–solute interactions, respectively. Solution viscosities were analyzed using the Jones–Dole equation and the viscosity A and B coefficients discussed in terms of solute–solute and solute–solvent interactions, respectively. Adiabatic compressibility ( $$ \beta_{s} $$ ) and apparent molar adiabatic compressibility ( $$ \phi_{\kappa }^{{}} $$ ), limiting apparent molar adiabatic compressibility ( $$ \phi_{\kappa }^{0} $$ ) and experimental slopes ( $$ S_{\kappa }^{*} $$ ) were determined from sound velocity data. The standard volume of transfer ( $$ \Delta_{t} \phi_{V}^{0} $$ ), viscosity B-coefficients of transfer ( $$ \Delta_{t} B $$ ) and limiting apparent molar adiabatic compressibility of transfer ( $$ \Delta_{t} \phi_{\kappa }^{0} $$ ) of metformin hydrochloride from water to aqueous glucose solutions were derived to understand various interactions in the ternary solutions. The activation parameters of viscous flow for the studied solutions were calculated using transition state theory. Hepler’s coefficient $$ (d\phi /dT)_{p} $$ indicated the structure making ability of metformin hydrochloride in the ternary solutions.