Viscometric and Conductometric Studies of Doxycycline Hyclate in Water, Aqueous Glycine and L-Alanine Solutions at Different Temperatures

Abstract

To investigate the behaviour of doxycycline hyclate in water, aqueous glycine and aqueous L-alanine solutions, the viscometric and conductometric studies have been conducted at different temperatures. Viscosity data has been used to derive the Jones-Dole viscosity B-coefficient, temperature derivative of B-coefficient (dB/dT), viscosity B-coefficient of transfer (ΔtrB), free energy of activation of viscous flow per mole of solvent (Δμ1 o*) and solute (Δμ2o*) respectively, activation entropy (ΔS2o*) and activation enthalpy (ΔH2o*). Conductance data has been used to compute Walden product (Λm oηo) and temperature coefficient of Walden product (dΛmoηo/dT) for doxycycline hyclate in water, and in aqueous glycine and aqueous L-alanine solution. The positive values of B-coefficient, ΔtrB indicate the prevailing of hydrophilic-ionic interactions in the systems under examination. The negative values of dB/dT and positive values of temperature coefficient of Walden product infer structure maker tendency of doxycycline hyclate in water, and in aqueous glycine and aqueous L-alanine solution. Transfer energy parameters indicate the breaking of intermolecular bonds in transition state which means that formation of activated complex is unfavourable