The subject of the research is the financial mechanism of the modern venture investment market under conditions of uncertainty and the requirements of accelerated innovative development. The study aims to analyze the impact of the pandemic on the sustainability of the institutional behavior of venture capital investment in the global and Russian markets. The authors apply such scientific methods as sampling, grouping, comparison, analogy, analysis, generalization, systemic-structural approach to assessing the development of the subject of research. The paper analyses the role of venture investment in the successful promotion of innovations using the example of the world’s leading companies in 2016–2021. Successful examples of venture investment are presented. The study investigates the impact of the pandemic and lockdown on the level of volatility, composition and dynamics of venture capital investments in 2020– 2021. The authors conclude that the pandemic has an impact on the sectoral redistribution of investments in favor of venture investments in medicine, biotechnology, the sector of information and communication technologies and solutions for business, education, healthcare, on market polarization (covid-negative, covid-positive, covid-neutral), on reducing the role of state funds and Russian accelerators, while increasing the interest and scale of participation of private institutions (foreign investors, business angels, syndicated angel investment), to increase of the volume of the Russian venture capital market by increasing the average ticket size despite the reduction in their number, to strengthen the practice reproduction of their own ecosystems by corporate institutions, to popularize venture capital investment deals in terms of mergers and acquisitions. Prospects for researching the venture capital market are associated with the constant attention to high-tech covid-positive projects, with the growth of transactions in the early stages, due to the increase in the number of professional communities, with the pinpoint development of specific tasks of an investor or corporation by accelerators, with venture investment of companies with the subsequent entry of the project into their own ecosystem, with the improvement of the state’s restrictive measures aimed at a clear institutionalization of professional activities and increasing the financial stability of participants in the investment and innovation markets, with the stimulation of mechanisms for regional innovative development to attract capital to high-risk projects in the regions.