Vegetative Disorders Research Articles

State of balance, functional mobility and biomechanical parameters of walking in men aged 25-42 years with the consequences of a combat injury

The main problem of a traumatic brain injury acquired during combat operations is a complication that develops after a while. The consequences of TBI are severe and include violations not only of the physical condition, but also of the psychosomatic sphere. Postural instability or imbalance is a common symptom in people with traumatic brain injury. The purpose of our work was to investigate and evaluate the state of walking locomotion in men aged 25-42 years with long-term consequences of a closed traumatic brain injury in the late long-term period. Under observation were 38 men aged 25-42 years with long-term consequences of a closed traumatic brain injury injury. The cause of disability was wounds and contusions associated with military operations. The patients were randomly divided into two groups: Gr.1 (n=20) and Gr.2 (n=18). Clinical picture of all patients Gr. 1 and Gr. 2 was the same. All the studied patients had the main neurological syndromes that limited their vital activity: vegetative disorders and discoordination of the vestibular genesis. The average balance indicator in the standing position after the Bohannon test testified to the instability to more maintain one's standing position, independently on both legs, in both groups studied. Assessment of vestibular coordination according to the "TUG" test in both groups of trainees indicated a statistically significant decrease in the data obtained compared to the standard indicator (р<0,05). All the subjects showed a decrease in all parameters of support ability and stability when standing. Fluctuations of the common center of pressure in the sagittal and frontal planes acquired significant differences compared to the standard value (р<0,05). The primary study of the dynamic characteristics of walking in patients of both groups indicated a deterioration in the main indicators of locomotion, namely the pace and speed of walking, as well as walking disorders in the form of temporal, kinematic and dynamic asymmetries in the studied Gr. 1 and Gr. 2 (р<0,05). That is, during the ascertaining experiment, we received confirmation of a decrease in all walking locomotions in men with complications after a combat injury. To restore walking locomotion, it is necessary to develop and implement vestibular rehabilitation programs.

A new and accurate qPCR protocol to detect plant pathogenic bacteria of the genus ‘Candidatus Liberibacter’ in plants and insects

Four pathogenic bacterial species of the genus ‘Candidatus Liberibacter’, transmitted by psyllid vectors, have been associated with serious diseases affecting economically important crops of Rutaceae, Apiaceae and Solanaceae families. The most severe disease of citrus plants, huanglongbing (HLB), is associated with ‘Ca. Liberibacter asiaticus’ (CaLas), ‘Ca. Liberibacter americanus’ (CaLam) and ‘Ca. Liberibacter africanus’ (CaLaf), while ‘Ca. Liberibacter solanacearum’ (CaLsol) is associated with zebra chip disease in potatoes and vegetative disorders in apiaceous plants. Since these bacteria remain non-culturable and their symptoms are non-specific, their detection and identification are done by molecular methods, mainly based on PCR protocols. In this study, a new quantitative real-time PCR protocol based on TaqMan probe, which can also be performed in a conventional PCR version, has been developed to detect the four known phytopathogenic species of the genus Liberibacter. The new protocol has been validated according to European Plant Protection Organization (EPPO) guidelines and is able to detect CaLas, CaLam, CaLaf and CaLsol in both plants and vectors, not only using purified DNA but also using crude extracts of potato and citrus or psyllids. A comparative analysis with other previously described qPCR protocols revealed that this new one developed in this study is more specific and equally or more sensitive. Thus, other genus-specific qPCR protocols have important drawbacks regarding the lack of specificity, while with the new protocol there was no cross-reactions in 250 samples from 24 different plant and insect species from eight different geographical origins. Therefore, it can be used as a rapid and time-saving screening test, as it allows simultaneous detection of all plant pathogenic species of ‘Ca. Liberibacter’ in a one-step assay.

Cardiovascular Reaction to Orthostatic Test Among Non-functional Overreaching Athletes with Vegetative Disorders (The Physical Therapist Perspective)

Aim: The non-functional overreaching requires a deeper study because its diagnosing is not based on conventional methods. Orthostatic and clinostatic tests make it easy and quick to detect health problems. The purpose of this research is defining orthostatic reactions among 68 athletes with and without signs of non-functional overreaching. Materials and Methods: Our research comprises 2 groups of 68 athletes subdivided by presence of non-functional overreaching. The first group includes 27 persons with vegetative disorder signs. The second group covers 41 individuals without non-functional overreaching. For all of them, we conducted orthostatic tests to record blood pressure and heart rate horizontally and vertically. Results: The research showed that 9 athletes (33.3% of the O+ group) had unsatisfactory results after body tests in horizontal and vertical positions. All athletes revealed the orthostatic tolerance disorder. For 5 sportsmen, the latter was accompanied by the clinostatic overreaction. Resting heart rate did not vary considerably between both groups (р=0.412). However, orthostatic tests reflected the sharp index rise among 9 individuals. For non-functional overreaching athletes, the mean value (р<0.001) exceeded the corresponding one in the O- group more than twofold. Conclusions: Although today it is possible to differentiate orthostatic-clinostatic tolerance from vegetative dysfunction, further research must be conducted to clarify this syndrome types and to improve physical recovery for non-functional overreaching athletes.

Vegetative Disorders in Medical Practice

Vegetative disorders are one of the urgent problems of modern medicine. This is due to several factors, and above all - the huge prevalence - of vegetative disorders, including among people who consider themselves practically healthy. The role of the autonomic nervous system in pathology stands out even more clearly. There are practically no such diseases in the development and course of which the autonomic nervous system would not play a role. Another feature of vegetative pathology is that it rarely acts as an independent disease. In some cases, it is a significant factor in pathogenesis, in others it occurs secondary in response to damage to any systems and tissues of the body. The review provides anatomy, physiology of the autonomic nervous system, the main factors leading to the development of autonomic disorders, the principles of classification of autonomic disorders, key points and diagnostic algorithms for autonomic disorders, as well as the principles of treatment.

Punctural Physiotherapy in Complex Rehabilitation of Elderly Patients with Large Joints Lower Extremities Pathology: a Narrative Review

AIM. To analyze of recently reported domestic and foreign studies on the influence of РhP on the results of rehabilitation of elderly patients after total endoprosthetics operations. MATERIAL AND METHODS. The review examines issues related to the pathogenetic aspects of punctural effects on the body, the peculiarities of using low-intensity physical factors of electromagnetic nature as a therapeutic stimulus when exposed to acupuncture points based on the results of clinical and experimental studies on cell cultures and animals published in Faberlink, Pubmed. The mechanisms of the influence of low-intensity laser, optical and extremely high frequency radiation on the adaptive reactions of the body are discussed. The results of experimental studies on the choice of optimal modes and parameters of low-intensity electromagnetic radiationof extremely high frequency are considered for the purpose of application in complex rehabilitation programs. The results of reflexodiagnosticsin the process of restoring vegetative disorders of the body as predictors of adaptive potential in the process of predicting the direction and volume of rehabilitation load, as well as the outcomes of rehabilitation treatment are evaluated. CONCLUSION. Further studies on the mechanisms of action and rehabilitation potential of low-intensity EMR in different ranges are needed to expand the clinical application of PhP techniques.

The Neurovegetative Status of Children 5-7 Years Old

The purpose of the article is to reveal the peculiarities of the neurovegetative status of children of senior preschool age. The article exposes the importance of the autonomic nervous system, features of electrical activity, cerebral blood flow on functioning of the child’s body. Childhood is a sensitive period of development of many neurophysiological and physiological functions. In children the electrical activity of the brain can be considered as an indicator of general properties of the nervous system and takes the leading place in the structure of the neurodynamic constitution of a person and some individual-psychological differences underlying them. Prolonged psycho-emotional overstrain, a high level of personal anxiety in children and the etiological factor cause increased activity of adaptation-compensatory reactions, in which the most important role is played by the autonomic nervous system. Disturbances of neurovegetative regulation, occurring practically in all diseases, under the influence of a huge number of damaging factors are nonspecific, adaptive-compensatory. In children, psycho-vegetative syndrome, characterized by a combination of psycho-emotional and vegetative disorders is encountered in most cases.

Determination of The Features of The Formation of Functional Training of The Cadets of The Institutions of Higher Education of The MIA of Ukraine

Determination of the features of the formation of functional fitness of the cadets of higher education institutions of the Ministry of Internal Affairs of Ukraine in the process of their educational and training classes is extremely important for ensuring the adaptive capabilities of the body and creating optimal conditions for increasing general and special physical fitness. Structural and functional restructuring of the regulation of the human body occurs under the influence of the educational and training process. The prerequisites for the development of the program for improving the physical and functional readiness of the cadets were the determination of the features of their functional state of the cardiovascular, respiratory, and vegetative systems at the beginning of the pedagogical research. The purpose of the study is to investigate the peculiarities of the formation of functional readiness of the cadets of higher education institutions of the Ministry of Internal Affairs of Ukraine. The object of the study is the functional training of the cadets of the Military Academy of the Ministry of Internal Affairs of Ukraine. The subject of the study is the cadets of the Military Academy of the Ministry of Internal Affairs of Ukraine. The subject of the study is the level of professional training of the cadets of the Military Academy of the Ministry of Internal Affairs of Ukraine. Research methods: theoretical analysis, systematization and generalization of data, methods of assessing the functional state of the external respiratory system, central hemodynamics and autonomic nervous system, methods of assessing the contractile function of the heart, methods of mathematical processing of the obtained results. Study results. In connection with the activity of mechanisms of neurohormonal regulation, changes in heart rhythm were considered as a result of the activity of various parts of the autonomic nervous system that modulated cardiac activity and heart rhythm. The need for a preventive approach to vegetative disorders in cadets of the Military Academy of the Ministry of Internal Affairs of Ukraine was established, the functional state of the sympathoadrenal system was determined, and the peculiarities of the vegetative regulation of the heart rhythm were revealed. The basis of pre-hospital diagnosis is the assessment of regulation, which made it possible to assess the functional status and reserves of adaptation due to the speed of response. Conclusions. According to the results of the survey of the cadets conducted at the ascertainment stage of the pedagogical research, reduced functional capabilities of the cardiovascular, respiratory and vegetative systems were established, which created the prerequisites for the development of an experimental program for their improvement through the use of means that include the whole body, universal schemes for engaging motility in several planes movements such as the basic elements of Jiu-Jitsu.

Neuropathies périphériques et facteurs associés chez les hémodialysés chroniques du Bénin

IntroductionPeripheral neuropathies, in hemodialysis patients, are frequent. ObjectiveTo study peripheral neuropathies in the population of chronic hemodialysis patients in Benin. MethodsThis was a descriptive and analytical cross-sectional study conducted from April 1st to July 31st, 2017 in the hemodialysis units of the two public dialysis centers in Benin. Recruitment was exhaustive with inclusion of all patients with hemodialysis for more than 3months, aged at least 18years and consenting. The diagnosis of peripheral neuropathy was based on the presence of sensory-motor and/or vegetative disorders associated with amyotrophy, abolition or reduction of osteotendinous reflexes and absence of central signs. ResultsA total of 189 hemodialysis patients were included in the two public hemodialysis centers of Benin, 180 at the CNHU-HKM and 9 at the CHUD/BA. The mean age was 50.23±13.31years with extremes from 20 to 85 years and a sex ratio of 1.59. The overall frequency of peripheral neuropathy was 59.26%, including polyneuropathies (72.32%), unifocal mononeuropathies (10.71%), polyradiculoneuropathies (9.82%), and multiple mononeuropathies (7.14%). The associated factor in multivariate analysis was socioeconomic level (P=0.001; OR 39.41; 95% CI 4.81–322.64). ConclusionPeripheral neuropathy is frequent in chronic hemodialysis patients in Benin, requiring early detection and management.

Impact of coronavirus infection on asthenic syndrome in patients with ischemic stroke

It is known that the presence of asthenic syndrome is characteristic of ischemic brain damage. At the same time, patients with acute cerebral ischemic stroke, who have been diagnosed with a laboratory-confirmed coronavirus infection with a mild and asymptomatic course without signs of damage to other organs, are of particular interest. The aim of the research was to identify and study the severity and duration of asthenic syndrome in patients with ischemic stroke under conditions of the coronavirus infection in order to determine the effect of asthenia on the quality of life in the post-COVID period. The subjects were patients with acute cerebral ischemic stroke with the NIHSS neurological deficit score of 12.0 [9.0;15.0], whose mean age was 58.82±3.29 years [Me=54; Mo=60.0]. The main group (38 people) included patients with laboratory-confirmed coronavirus infection without signs of damage to other organs; the comparison group (31 people) consisted of patients with AMI only, comparable to the main group in all respects, including the set of vascular risk factors. All patients underwent a clinical and neurological examination, an examination by a general practitioner and / or a cardiologist, CT using an angio mode, the MFI-20 questionnaire, A. M. Wein questionnaire, Spielberger and Khanin scale. Quality of life was assessed using a short version of the MOS SF-36‑ltem questionnaire. Statistical analysis of the obtained results was carried out via statistical programs Microsoft Office Excel 2007 (USA) and Statistica for Windows, v. 10.0. It has been established that the coronavirus infection aggravates the course of asthenic syndrome in patients with acute ischemic stroke, has a long-term effect on the recovery process, remains relevant in the post-COVID period, and is accompanied by anxiety and vegetative disorders. Organic symptomatic asthenia largely determines the course of the pathological process, affecting the general condition, performance, social adaptation and, as a result, the quality of life of the patient.

The use of GAMMAVITAL in the treatment of anxiety and non-psychotic depressive disorders

The article is devoted to the issues of effective pharmacotherapy in anxiety and non-psychoticdepressive disorders. Chronic stress and emotional overload, CoVID-19 disease lead to the appearance of neurogenic and psychosomatic diseasessymptoms. Recent events in the world and Ukraine have significant influenceonnervous systemgeneral state, so the nervous system needs support and help. The article provides an analysis of the scientific research resultsof effects on the nervous system for such active pharmaceutical ingredients as magnesium diglycinate, vitamin B 6 (pyridoxine), gamma-aminobutyric acid (GABA), saffron extracts and the amino acid 5-hydroxytryptophan. A rational combination of all these components is the domestic medicine «GAMMAVITAL», which has no analogues on the pharmaceutical market.
 The use of combined medicines, in particular Gammavital, the composition of which ensures the synergism of its components and potentiates their combined effect, opens up new perspectives in the prevention and treatment of anxiety and mild depressive states, sleep disorders, neurotic and vegetative disorders.

Quality of life, vestibular discoordination and violation of the walking pattern of amateur athletes with long-term consequences of traumatic brain injury

Among the participants in the hostilities in the East of Ukraine, military personnel receive a brain contusion three times more often than other injuries. The main problem of closed craniocerebral injury is that complications appear after some time. The aim of the work was to investigate the consequences of traumatic brain injury accompanied by brain contusion in amateur athletes. All the tested athletes had the main neurological syndromes that limited their vital activity: vegetative disorders and discoordination of the vestibular genesis. Under observation were 12 men aged 25-42 years with long-term consequences of a closed craniocerebral injury in the late long-term period. The duration of the post-traumatic period is from six months. The cause of disability was wounds and contusions associated with military operations. In all patients, complications after TBI were a decrease in muscle strength in the lower extremities, impaired coordination and balance, and a walking pattern. According to the International Classification of Functioning, limitation of vital activity and health in subjects in the domain "Structure and functions of the body" was observed mono- or hemiparesis of the lower extremities. In the activity and participation domain, patients complained about being able to return to amateur sports. When assessing the quality of life on the VAS scale, a low level of quality of life was revealed. According to the Lovett manual muscle test, it was found that in the subjects in the late long-term period after injury, there is a decrease in muscle strength of both the anterior and posterior thigh and lower back muscle groups. The results of the Bohannon test showed an increased risk of falling due to imbalance. «Timed Up and Go» testing indicated a statistically significant decrease in vestibular coordination and gait pattern compared to the norm.

The features of optimal nonhormonal therapy of vegetative disorders among women with postmenopause

Objectives: to evaluate the clinical effectiveness of the Vitae-Melatonin in the complex treatment of vegetative disorders in postmenopausal women.Materials and methods. The 64 postmenopausal women who complained of vegetative disorders were included in our prospective study. Patients were divided into clinical groups. The first group consisted of 31 women who were prescribed a herbal preparation of Cimicifuga racemosa extract – 30 mg/day for 3 months. The second group included 33 patients who received in addition to the herbal medicine Vitae-Melatonin 3 mg/day every evening 2 hours before bedtime for 1 month. The clinical effectiveness of the therapy was assessed 1, 2 and 3 months after the start of treatment based on the dynamics of psychological disorders, somatic symptoms, vasomotor and sexual disorders, sleep problems and satisfaction with the therapy.Results. The use of herbal medicine containing Cimicifuga rhizome extract alone or in combination with Vitae-Melatonin in postmenopausal women significantly reduced the manifestations of vegetative disorders, including psychological and dyssomnia in a month from the start of therapy. After 3 months from the start of therapy, the advantage of combined therapy involving Vitae-Melatonin compared to the monotherapy of Cimicifuga rhizome was marked by a significant reduction of psychological disorders, somatic symptoms, vasomotor disorders and sleep problems (р = 0.003, р = 0.01, р = 0.02 and p = 0.015, respectively). Patient satisfaction with the combined therapy of vegetative disorders during the menopause compared to monophytotherapy was probably higher (risk ratio 1.63, 95% confidence interval 1.09–2.44, p = 0.018). There was no significant difference between the two research groups regarding side effects during and after the use of the drugs (p > 0.05).Conclusions. The use of Vitae-Melatonin at a dose of 3 mg/day in addition to phytotherapy in postmenopausal women had a clear clinical effect, which was a significant reduction of vegetative disorders, both compared to the initial indicators and in comparison with monophytotherapy. Results of the study showed the safety of melatonin, as well as the willingness of participants to continue using melatonin after 3 months of the treatment.

Outcome of COVID-19 in children: results of a 12-month follow-up

At present, there are isolated data on the clinical outcomes of COVID-19 in children, especially those who have experienced asymptomatic and mild forms of infection.Purpose: to analyze the nature and frequency of postCOVID symptoms in children during 12 months. after recovery.Materials and methods. The influence of demographic indicators, premorbid background, severity of infection and therapy in the acute period of the disease on the nature and frequency of symptoms in 1079 children who underwent laboratory-confirmed COVID-19 was studied. The results are presented with proportions (%) and calculation of 95% confidence interval according to Klopper-Pearson. Differences between groups were assessed using Pearson’s chi-square test. Differences in the groups were considered statistically significant at p < 0,05.Results. Health disorders in the post-COVID period were observed in 8,5% of children, more often in school-children aged 7–17 years (68.4%). Concomitant conditions were found in 38,0%. In most cases, the consequences were noted after a mild form of COVID-19 (77.2%), however, 13,0% of patients experienced an asymptomatic form of infection. Among convalescents, changes in the emotional sphere (2,1%), headache (1,8%), symptoms of asthenia (1,6%), cardiovascular (1,5%), dyspeptic (1,3%) were more often observed, cognitive (1,3%) disorders, neurotic disorders (1,0%), less often respiratory (0.8%), endocrine (0,4%) and visual (0,4%) systems, musculoskeletal system were involved (0.2%). Girls were significantly more likely to have vegetative disorders, while boys were significantly more likely to suffer from cognitive functions. Various antiviral therapy options (interferon-alpha, an oral antiviral drug, or a combination thereof) in the acute period of COVID-19 did not affect the possibility of post-COVID disorders, but there was a tendency to increase the frequency in children who did not receive etiotropic treatment (control group). In 14.1% of cases, post-COVID symptoms appeared late – after 5–10 months. after recovery. The course of rehabilitation therapy, including drug treatment and non-drug methods, made it possible to quickly restore the state of health of the observed children.Conclusion. In most cases, the violations were of a functional nature, due to a disorder of autonomic regulation. Rehabilitation and dispensary observation programs will allow timely restoration of the quality of life of children who have had COVID-19, including in a mild and asymptomatic form.

Comprehensive Psychological Analysis of The Features of Emotional Burnout Among IT Specialists: The Ukrainian Labor Market

The article includes an analysis of the symptoms (occurred at the stages of formation) of emotional burnout of IT workers in the labor market of Ukraine in accordance with experience in the profession, type of programming - BackEnd, FrontEnd and kind of work organization involving absence and presence of communication with the client within the project. The use of the method of Victor Boyko determined the symptoms of emotional burnout. The study involved 75 programmers, divided into three groups based on the duration of professional experience including up to 5 and 10 years, and more than 10 years. The study revealed the opposite trend between work experience and the main symptoms of emotional burnout occurring at the already formed stage and the phases of “resistance” and “exhaustion” marked by the decrease in the percentage of formed symptoms and increase in the percentage of symptoms at the stage of formation. The FrontEnd group demonstrated the most pronounced symptoms of emotional burnout as a manifestation of the simplification of emotional emphasis in the profession. The BackEnd showed the symptoms of emotional burnout as a manifestation of the simplification of professional responsibilities. The severity of symptoms of psychosomatic and psych vegetative disorders and self-dissatisfaction occurred in the FrontEnd group at the stage of symptoms formation of emotional burnout. The research did not show the already formed symptoms in this group. The project revealed a higher percentage of symptoms of emotional burnout in the phases of "resistance «and "exhaustion" in the group having no communication with the client, than in the group with communication with the client.

Distribution of vegetative dysfunctions and depressive positions among sexually active students and students without sexual debut of National Pirogov Memorial Medical University, Vinnytsya

Annotation. Autonomic dysfunction syndrome is one of the most common disorders, which has a wide range of interpretations among specialists of different profiles. The autonomic nervous system (ANS) occupies a significant place in the development of somatic pathology. The course and manifestation of all pathological conditions is associated with autonomic dysfunction. Together with vegetative disorders, depressive disorders are also widespread among students. The aim of the study: to identify the clinical psychopathological features of somatized depressive disorders and autonomic dysfunction among sexually active students in comparison with students without a sexual debut of 4th year of study at Vinnytsya National Pirogov Memorial Medical University. A survey of 308 medical students was carried out. Obtained data were analyzed using the program “Statistica 6.1” using nonparametric methods of estimation of the obtained results. It was found that among medical students is a very high percentage of depressive disorders (96.1%) and disorders of autonomic function (69.8%). However, the manifestations of vascular dysfunction in young people are not related to their sexual activity. Mild and minimal manifestations of depressive disorders are also not associated with sexual activity. Symptoms of very severe depression are more prevalent in virgin girls than in sexually active girls and boys.

The study of the impact of rehabilitation measures on the dynamics of cognitive disorders in Parkinson’s disease

Aim. To assess the level of cognitive impairment and its dynamics over 6 months in Parkinson’s disease.
 Materials and methods. The study involved 31 people with Parkinson’s disease, including 15 women and 16 men. The average age of patients at the beginning of the study was 65.1 (m = 0.54). The duration of the disease varied from 3 to 8 years. The Mini-mental State Examination (MMSE) and the Mattis dementia scale were used to study cognitive functions. The Wechsler Adult Intelligence Scale (WAIS) was used to assess attention. The study of speech was conducted using the free and directed association test, and visual-spatial functions were studied using the “drawing clock” test. The visual memory test from the SKT test battery was used to assess memory, and affective disorders were studied using the Beck Depression Scale. Depression was diagnosed according to the ICD-10 criteria. The vegetative disorders were assessed using the autonomic disorders scale. The results obtained were processed using mathematical statistics methods.
 Results. The data obtained in the course of the study allow us to state the stability in disturbance of the vegetative function. The affective symptoms in patients with mild cognitive impairment were improved. In patients with moderate and severe cognitive impairment, affective symptoms remained stable. There were also no significant changes in the Mattis dementia scale, the Beck Depression Scale, the coding test, visual-spatial functions, grammatical associations, semantics and phonetics.
 Conclusions. The studies showed that after the introduction of a comprehensive rehabilitation program for 6 months there were minor improvements indicating the need for further improvement and implementation.

A personified approach to the treatment of vegetative disorders in patients with prevential stomach conditions using Pure Purr complex

Background. Indicators of heart rate variability are reliable and objective indicators of the tone of the autonomic nervous system (ANS), which reflects changes in the psycho-emotional state of man against the background of stress. Stress management programs include a variety of relaxation techniques and cognitive behavioral therapy. Therefore, the purpose of the study was to optimize the treatment of patients with chronic atrophic gastritis with autonomic disorders using software and hardware for parasympathetic activation of the ANS. Materials and methods. Indicators of heart rate variability were studied in 80 patients with chronic atrophic gastritis based on the results of PRECISE diagnostics, which allowed to identify patients with hypersympathicotonia and treat them with 10 sessions on Pure Purr software and hardware complex to assess the dynamics of heart rate variability. Results. 72.7% of patients with chronic atrophic gastritis, who showed a decrease in heart rate variability due to activation of the sympathetic tonic ANS and insufficient activity of its parasympathetic tonic, breakdown of adaptation, lack of stress and functional reserves of the body were treated with neurostimulation. After treatment, positive dynamics was determined in the form of a significant increase in heart rate variability by increasing its components due to the parasympathetic nervous system, which prevents increased sympathetic influences and improves disease and prognosis by normalizing adaptation, functional reserves and stress resistance. Conclusions. Treatment of patients with chronic atrophic gastritis with autonomic disorders should be comprehensive with the inclusion of hardware with neurostimulation software aimed at reducing hypersympathicotonia with increasing adaptive capacity of the body.

Correction of sexual dysfunction in postmenopausal women

Annotation. In the postmenopausal age, the quality of sexual life deteriorates significantly. To date, there are no effective methods for correcting sexual dysfunction (SD) in women of this age. The aim of the study was to compare the clinical efficacy of traditional drugs for menopausal hormone therapy (MHT) – tibolone and a complex drug containing 1 mg of estradiol and 5 mg of dydrogesterone for SD in postmenopausal women. 69 postmenopausal women with SD were monitored: 37 – the main group (MG), 32 – the comparison group (CG). MG women were treated a drug’s containing tibolone, 1 pill once a day. Women with CG were prescribed traditional menopausal hormone therapy (MHT) with a drug containing 1 mg of estradiol and 5 mg of dydrogesterone. The quality of sexual life was determined before treatment and 1 month after treatment using a specially designed questionnaire and menopause rating scale (MRS). Statistics were processed using LibreOffice Calc (Mozilla Public License v 2.0). Quantitative data from the two related groups (before and after treatment) were compared using the Wilcoxon signed rank test. When considering the results in an alternative form (the presence or absence of a certain feature used Fisher's angular transformation. Pairwise comparisons of groups were performed using the Mann-Whitney test at p <0,05. In the treatment of SD in women with MG there was a reduction of all symptoms; in patients with CG - improvement of only one indicator was observed. In MG, after 1month treatment of SD, the number of women satisfied with their sexual life increased 2.4 times (p<0.05), and in CG – 1.4 times (p>0.05). Significant reduction in most menopausal symptoms was observed in both groups of women after treatment. According to psychoneurological indicators and atrophic changes of the vagina, the difference between MG and CG after treatment was not detected (p>0.05). Besides, the best correction of climacteric vegetative disorders in CG was found in comparison with MG (p<0.05). In MG has been noted significant improvement in physical and mental health disorders and joint and muscle discomfort compared with СG (p <0.05). Recovery of urinary disorders during a month of therapy with MHT drugs was not observed in any group of studied women. Thus, the drug based on tibolone can be recommended for the correction of sexual dysfunction in postmenopausal women.

Dynamics of vegetative, insomnia and neuropsychological manifestations during the treatment of post-COVID syndrome

Introduction. Asthenia, vegetative manifestations, sleep disturbances and psycho-emotional background are companions of the coronavirus infection, the issue of drug correction of which is especially relevant. These symptoms disrupt the habitual way of life of patients for a long time, and in special cases lead to disability.Aim. To study the mental, somatoform and cognitive aspects of anxiety disorders after coronavirus infection during treatment with tofisopam (Grandaxin®) 150 mg/day.Materials and methods. The study included patients who had experienced a new coronavirus infection, who, after the end of treatment for the underlying disease, had complaints suggesting the presence of an anxiety disorder. The Hamilton scale was used to assess the level of anxiety. Examination of patients was carried out before the start of treatment, after 2, 4 and 6 weeks of therapy.Results and discussion. Prior to the start of therapy, all patients had an overall high level of anxiety: the average HAM-A score was 31.4 ± 2.92 points. At the end of Grandaxin® therapy, all patients showed a decrease in the level of anxiety: the average HAM-A score was 12.08 ± 2.27 points (p < 0.001). The maximum decrease in the severity of vegetative disorders was noted by the end of the 6th week of therapy with Grandaxin®. Thus, the indicator of this subscale decreased by more than 2 times – from 2.46 ± 0.54 to 1.05 ± 0.28 points (p < 0.001). The severity of insomnia during six weeks of therapy with Grandaxin® decreased from 2.56 ± 0.54 to 0.96 ± 0.45 points (p < 0.001).Conclusion. Psycho-emotional disorders (more often in the form of increased personal anxiety), sleep disorders, vegetative disorders, asthenic syndrome significantly affect the quality of life of patients who have had a new coronavirus infection. Involvement of the structures of the autonomic nervous system and central structures that regulate GABAergic transmission leads to significant vegetative failures, which requires pathogenetically substantiated drug correction of these disorders.

Cognitive, emotional-affective, anxiety and autonomic disorders in patients with a new coronavirus infection (covid-19) in the acute period

The purpose of this work is to identify neuropsychiatric functions in patients at Department No. 1 responsible for medical care of patients with a new coronavirus infection at the Samara City Hospital No. 7. Appropriate scales and questionnaires were used for this purpose. Cognitive impairments were found in 86% of the cases, emotional-affective impairments of varying severity in half of the subjects, an increase in reactive and personal anxiety was revealed, and vegetative disorders were observed in 78% of the subjects. Based on these data, it can be assumed that the new coronavirus infection affects the functioning of the nervous system of patients.