BACKGROUND AND AIM: It has been suggested that environmental exposures to pesticides and cleaning detergents have an increased risk of respiratory and allergic symptoms in adults. However, the evidence of residential exposure to pesticides and cleaning detergents with increased risk of respiratory and allergic symptoms among farmworkers is limited. The aim was to investigate the association of environmental exposure to pesticides and cleaning detergents with increased risk of respiratory and allergic symptoms in farmworkers. METHODS: In this cross-sectional analysis, we included farmworkers at the ages of 18 and 48 years from Kilimanjaro and Arusha region with information on residential exposure to pesticides, cleaning detergents, cough, rhinitis, wheeze, shortness of breath, cough with phlegm and itching skin collected in 2021 (N = 389) through administered questionnaires. Logistic regression analysis was used to estimate associations between exposure and outcomes, adjusting for potential confounders. RESULTS: Cleaning detergents was associated with an increased risk of cough among farmworkers [adjusted odds ratios (95% CI) 3.90 (1.33, 11.38)]. However, there was a reduction of risk for itching when the farmworkers use cleaning agents [adjusted odds ratios (95% CI) 0.32 (0.16, 0.67)]. We found that there were risk reduction for cough, rhinitis, wheeze, shortness of breath, cough with up phlegm, difficulty in breathing and itching skin for farmworkers who had vegetable garden at their homes [adjusted odds ratios (95% CI) 0.31 (0.18, 0.54),0.48 (0.29, 0.78), 0.14 (0.05, 0.37), 0.35 (0.13, 0.96), 0.18 (0.07, 0.44), 0.20 (0.09, 0.47), 0.49 (0.25, 0.96)]. CONCLUSION: The findings of this study suggest that vegetable gardens at their homes had public health concerns as it reduced the risk of respiratory and allergic symptoms among our study participants. This is an important issue for future research. KEYWORDS: Pesticides, Cleaning detergents, Respiratory, Allergic.