Purpose: To elucidate the effects of frontal plane lower limb alignment on gait biomechanics, we compared knee joint moments and frontal plane angular impulse before and after varus or valgus producing osteotomy in patients with lateral or medial compartment osteoarthritis, and in healthy participants with neutral alignment. Methods: Thirty-nine subjects participated (13 valgus gonarthrosis, 13 varus gonarthrosis, 13 controls). Patients underwent 3D gait analysis and radiographic assessment of alignment (mechanical axis angle; MAA) before and 6 months after surgery, and were compared to controls. Moments in each of the three orthogonal planes of movement were determined throughout stance phase and averaged over five trials of the same limb (operative limb, or limb closest to neutral for controls) while normalizing to body weight and height (%BW·Ht). Knee moments in all three planes were normalized to 100% of stance and peak values in the first and second halves of stance were identified. The frontal plane knee moment waveform was then integrated with respect to time to calculate the frontal plane knee angular impulse (%BW·Ht·s). Results: An ensemble average for the frontal plane knee moment before and after surgery with 95% confidence interval (CI) bars is illustrated in Figure 1. Mean changes (95%CI) in frontal plane angular impulse indicated a 0.82%BW·Ht·s (0.49,1.14) increase in adduction impulse in patients after varus osteotomy, and a 0.61%BW·Ht·s (0.37,0.86) decrease in adduction impulse in patients after valgus osteotomy, equating to a 53% and 45% change from preoperative values, respectively. Preoperative frontal plane angular impulse was significantly different between both patient groups and controls before surgery, but not after. There were less substantial findings in sagittal and transverse plane moment peaks. When compared to controls, the peak knee extension moment was significantly lower for both patient groups after surgery (p=0.008). The association between the changes in lower limb alignment and frontal plane knee angular impulse are plotted in Figure 2 (R=0.88, n=26). Conclusions: The cross-sectional data suggest that frontal plane angular impulse is very highly correlated to MAA before surgery (R=0.87), but not after (R=0.39), and that an adduction impulse predominates until 7º of valgus, at which point an abduction impulse predominates. The prospective surgical realignment data indicate that for every 1º change in MAA toward varus, there is a 0.1%BW·Ht·s (or 1.6N·m·s) change in frontal plane knee angular impulse toward adduction, and vice versa (Figure 2). These overall findings illustrate the potent effects that lower limb alignment can have on gait biomechanics. $$grap ic_94AB0E34-8D38-4F8A-AE45-E659B861CC5A$$ $$grap ic_AC2006D2-0EC3-4301-889F-EBA8CB318D37$$ Figure 2Scatter plot with mean regression line and 95% confidence interval.View Large Image Figure ViewerDownload Hi-res image Download (PPT)