Microplastic pollution presents a serious risk to marine ecosystems worldwide, with West Africa being especially susceptible. This study sought to identify the key factors driving microplastic dynamics in the region. Using NASA's Giovanni system, we analyzed environmental data from 2019 to 2024. Results showed uniform offshore air temperatures due to turbulence (25.22–45.62 K) with significant variations nearshore. Salinity levels remained largely stable (4 PSU) but slightly decreased in southern Nigeria. Surface wind speeds rose from 4.206–5.026 m/s in Nigeria to over 5.848 m/s off Mauritania, while eastward stress hotspots were prominent in Nigeria and from Sierra Leone to Senegal. Photosynthetically available radiation (PAR) beam values peaked off Mauritania and dipped from Nigeria to Sierra Leone, with the inverse pattern observed for diffuse PAR. Hotspots of high absorption, particulate backscattering, elevated aerosol optical depth, and remote sensing reflectance all pointed to substantial particulate matter concentrations. The Microplastic Vulnerability Index (MVI) identifies the coastal stretch from Nigeria to Guinea-Bissau as highly vulnerable to microplastic accumulation due to conditions that favor buildup. In contrast, moderate vulnerability was observed from Guinea-Bissau to Senegal and in Mauritania, where conditions were less extreme, such as higher offshore temperatures that could promote widespread microplastic suspension and cooler nearshore temperatures that favor sedimentation. Increased turbulence and temperatures in coastal areas of Senegal and Mauritania may enhance microplastic transport and impact marine life. In Nigeria, stable coastal conditions—characterized by consistent temperatures, low turbulence, and uniform salinity—may lead to increased persistence and accumulation of microplastics in sensitive habitats like mangroves and coral reefs. These findings highlight the need for region-specific management strategies to address microplastic pollution and effectively protect marine ecosystems.