Exposure Values Research Articles

Safety assessment and quality control of regenerated cellulose food packaging in different processes

Regenerated cellulose food packaging is increasingly widely used due to its renewable raw materials and excellent environmental performance. However, because its production process is complex, the safety of the regenerated cellulose food packaging needs to study carefully. In this study, we first collected the packages produced by traditional and new technology, and then HS-GC-MS was used to screen the volatile potential migrants in the package. Three food simulants were used for migration tests. The migrants from the regenerated cellulose food packaging during the contact with different foods were non-targeted screened and semi-quantitative by UPLC-QTOF-MS and GC-MS. The results show that 44 kinds of substances migrated to food simulants, and assessed their risk in conjunction with production processes. Glycerol or triethylene glycol as softeners, migrated in all three simulants and all types of packaging materials. Polyethylene glycol is detected in packaging materials with coatings, that come from adhesives. Allure red and its degradation products used for food coloring were detected in the transferable casing. The degradation product belongs to aromatic amine, which poses a high risk. Glycerol has the highest abundance among all migrants. By comparing the exposure and safety threshold values of migrants, it was found that polyethylene glycol and allure red pose health risks and should be paid more attention.

Characterisation of Portuguese radiotherapy departments: Organisation, occupational exposure values and diagnostic reference levels for breast and prostate computed tomography planning

IntroductionPortugal currently hosts 24 active radiotherapy departments, 8 public and 16 privates, presenting potential radiation exposure risks to multidisciplinary teams. Patients in these treatments also face ionising radiation during treatment planning and verification. MethodsAuthorisation and ethical approval were secured for a national online survey, disseminated to radiotherapy departments across Portugal. The survey encompassed three sections: equipment, staff, and radiographer role characterisation; occupational exposure values for one month; and exposure parameters, including computed tomography (CT) dose values [CT dose index (CTDIvol) and dose length product (DLP)] for breast and prostate cancer CT planning. Local Diagnostic Reference Levels (DRLs) derived were based on the 75th percentile of median dose values. ResultsThe study garnered a 50% response rate from public institutions, 12,5% from private and 25% from all active radiotherapy institutions in Portugal. All departments employ Three-Dimensional Conformal Radiation Therapy (3D–CRT) and incorporate Intensity Modulated Radiation Therapy (IMRT) and/or Volumetric Modulated Arc Therapy (VMAT) irradiation techniques. Additionally, half of the departments also perform Brachytherapy (BT). Radiographers demonstrated an occupational dose of zero mSv. CT planning dose values were 13 mGy and 512 mGy cm for breast CT and 16 mGy and 689 mGy cm for prostate CT, pertaining to CTDIvol and DLP, respectively. ConclusionMost aspects of national radiotherapy characterisation align with the established literature. Occupational exposure values exhibited consistency across radiotherapy modalities. An approach to national DRLs was formulated for breast and prostate CT planning, yielding values congruent with recent European studies. Implications for practiceThis study offers vital insights for analysing occupational contexts and risk prevention, serving as the initial characterisation of the national radiotherapy landscape. It also pioneers the calculation of DRLs for CT planning in radiotherapy to optimise procedures.

Aflatoxin M1 Exposure and Health Risk Assessment in Children and Adults due to Pasteurized Milk Consumption in Addis Ababa, Ethiopia

Milk and dairy products stand as essential sources of nutrition across all age groups. However, the presence of Aflatoxin M1, particularly common and risky for young children, necessitates careful assessment of milk. This study, conducted in Addis Ababa, Ethiopia, aimed to evaluate the prevalence of Aflatoxin M1 using High-Performance Liquid Chromatography in pasteurized milk and assess associated health risks using deterministic techniques. The prevalence of Aflatoxin M1 in pasteurized milk was 56.6%, with Aflatoxin M1 levels ranging from 0 to 6.27 μg/L and a mean value of 1.237 μg/L. The risk assessment revealed substantial Aflatoxin M1 exposure risk from pasteurized milk consumption, as reflected by margin of exposure values <10,000, specifically 25.9, 109.6, and 380 for children aged 2–5, 6–9, and adults, respectively. The hazard index values for pasteurized milk consumers were 110, 26, and 7.5 for children aged 2–5, 6–9, and adults, respectively. Furthermore, cancer risk calculations yielded values of 0.18, 0.04, and 0.01 per 100,000 population for children aged 2–5, 6–9, and adults, respectively, with an average potency of 0.007978 cases per 100,000/yr ng Aflatoxin M1/kg bw/day. Notably, children aged 2–5 and 6–7 face elevated risks, whereas adults face relatively lower risks.

Ambient air concentrations of plant protection products: Data collection for the combined air concentration database and associated risk assessment

CropLife Europe collected literature values from monitoring studies measuring air concentrations of Plant Protection Products (PPPs) that may be inhaled by humans located in rural areas but not immediately adjacent to PPP applications. The resulting “Combined Air Concentration Database” (CACD) was used to determine whether air concentrations of PPPs reported by the French “Agency for Food, Environmental and Occupational Health & Safety” (ANSES) are consistent with those measured by others to increase confidence in values of exposure to humans. The results were put into risk assessment context. Results show that 25–90% of samples do not contain measurable PPP concentrations. Measured respirable fractions were below EU default air concentrations used for risk assessment for resident exposure by the European Food Safety Authority. All measured exposures in the CACD were also below established toxicological endpoints, even when considering the highest maximum average reported concentrations and very conservative inhalation rates. The highest recorded air concentration was for prosulfocarb (0.696 μg/m³ measured over 48 h) which is below the EFSA default limit of 1 μg/m³ for low volatility substances. In conclusion, based on the CACD, measured air concentrations of PPPs are significantly lower than EFSA default limits and relevant toxicological reference values.

Optimization of leaf area index measurement method and correction of green plot ratio formula based on regional plant characteristics-a study in Chongqing, China.

The quantification of green space green plot ratio (GPR) is mostly based on estimation formulas, and the leaf area index (LAI) estimation values in these estimation formulas have not been well verified by measured LAI values, resulting in errors and uncertainties in GPR quantification results. This study aims to address this gap by measuring the LAI of 113 regional plants in Chongqing, China, following a standardized measurement path for digital hemispherical photography (DHP). The results indicate that the optimal relative exposure value (REV) was - 1 under overcast conditions and - 2 under sunny and cloudy conditions. Among the threshold algorithms for hemispherical images, the Intermodes algorithm in ImageJ was the best. The LAI of regional plants is highest in summer, followed by spring and autumn, and lowest in winter. Tree height (h) and crown width (w) are key factors affecting LAI, but the LAI also varies with plant species. Overall, the LAI of evergreen trees is higher than that of deciduous trees. The LAI of evergreen trees and shrubs with a height shorter than 5m is the largest, and that of deciduous trees and shrubs with a crown width larger than 8m is the largest. The study further verified that the existing GPR estimation formula exhibited large errors in Chongqing, while there was a strong correlation (R2 = 0.973) between the GPR estimation value and the measured value. A conversion formula was developed to reduce estimation biases, and the corrected formula is capable of estimating GPR values more accurately when actual LAI measurements are insufficient. Overall, this study verifies the significance of measuring localized LAI values, promotes the understanding of LAI suitability for GPR calculations, and provides an empirical formula for GPR estimation in Chongqing, China.

Assessment of the potential threats to brain health posed by the radiation from 5G sub-6GHz base stations in China using dosimetric methods.

The 5G sub-6GHz radio frequency (RF) electromagnetic fields (EMF) are the most widely used in China's communications. The public has expressed concerns about possible brain health effects of the higher frequency bands in 5G compared to 2G, 3G, and 4G bands. It is imperative to empirically investigate the potential health hazards of these novel frequency bands in 5G communication technology. This study evaluates the assessment of brain tissue dose coupling from sub-6GHz band EMF emitted by base stations in China. Based on the 3D virtual human body model, the simulation environment was established. Dose including specific absorption rate (SAR) and internal electric field (IEF) between 2G, 3G, and 4G bands and 5G sub-6GHz was investigated using normalized exposure values and exposure limits. The results indicate that the sub-6GHz high-frequency band of 5G has the lowest dose value. It can be concluded that high-frequency electromagnetic radiation in 5G sub-6GHz reduces the dose and health threats to the brain. This provides strong support for the promotion of 5G commutation in China and other regions.

Proposals for new transfer coefficient (TC) values for worker re-entry activities in grape vineyards

New transfer coefficient (TC) values were derived for vineyard workers handling treated grapevines during harvesting and crop maintenance activities. Re-entry exposure and dislodgeable foliar residue (DFR) studies were performed in Europe, covering hand harvesting, pruning/training, pruning/tying and pruning/shoot lifting. Foliar applications of fungicides (iprovalicarb, dimethomorph, dithianon, pyrimethanil and fenbuconazole) were made and 73 workers at 16 sites were monitored over one working day. Exposure was measured on inner and outer dosimeters, face/neck wipes and hand washes. In concurrent DFR studies, leaf punches were taken at each site during the time of worker re-entry. Potential exposure values correlated well with DFR values. TC values were derived for various re-entry activities for potential and actual exposure, with and without gloves. The harvesting task resulted in lower TC values than the other crop maintenance tasks. Additional TC values reflecting the use of protective gloves can be derived from the results. The TC values are much lower than current European Food Safety Authority (EFSA) default values. This project addresses a data gap identified by EFSA for specific EU TC values to permit more realistic and reliable re-entry worker exposure estimates for grapes.

Climate risk and opportunity exposure and firm value: An international investigation

AbstractWhile previous studies mainly focus on the valuation of greenhouse gas (GHG) emissions and climate risk exposure, climate opportunity exposure is less frequently visited in the current literature. We use an international sample from 23 countries that have participated in the CDP. By categorizing climate risks/opportunities into physical, regulatory and other, the study suggests that investors have an asymmetrical valuation for different categories of risks and opportunities. Specifically, investors value climate regulatory risk and other (market‐based) climate risks negatively, but not similarly for recognized climate opportunities. Finally, our findings confirm industry matters for investors' valuation decisions by altering their perceptions of the significance of climate risks and opportunities.

Study on impact of robotic-assisted orthopaedic industrial noise (SIREN).

The aim of this study was to evaluate noise exposure to the operating room staff consisting of the surgeon, assistant, anaesthetist and Mako Product Specialist (MPS) during Mako robotic-arm assisted total knee arthroplasty (TKA) and total hip arthroplasty (THA). We aimed to determine whether employees were exposed to noise at or above a lower exposure action value (LEAV) set out by the Noise at Work Regulations 2005, Health and Safety Executive (HSE), UK. We prospectively recorded intra-operative noise levels in Mako robotic-arm assisted TKA and THA over a period of two months using the MicW i436 connected to an iOS device (Apple), using the Sound Level Meter App (iOS) by the National Institute for Occupation Safety and Health (NIOSH). Data obtained was then used to calculate "worst case" daily exposure value to assess if sound levels were compliant with UK guidelines. Comparison between operating room staff groups was performed with ANOVA testing. A total of 19 TKA and 11 THA operations were recorded. During TKA, for the primary surgeon and the assistant, the equivalent continuous sound pressure level (LAeq) was over 80 dB, exceeding the LEAV set out by the Noise at Work Regulations by HSE. During THA, the average LAeq and peak sound pressure levels did not exceed the LEAV. The calculated daily exposure for the primary surgeon in TKA was 82 dB. A Tukey post hoc test revealed that LAeq was statistically significantly lower in the anaesthetist and MPS (p < .001) compared to the primary surgeon and assistant in both TKA and THA. Operating room staff, particularly the primary surgeon and assistant are exposed to significant levels of noise during Mako robotic-arm assisted TKA and THA. Formal assessments should be performed to further assess the risk of noise induced hearing loss in robotic-arm assisted arthroplasty.

Development of a generalized pharmacokinetic model to characterize clinical pharmacokinetics of monomethyl auristatin E-based antibody-drug conjugates.

This study aims to develop a generalized pharmacokinetic (PK) model for monomethyl auristatin E (MMAE)-based antibody-drug conjugates (ADCs) that can simultaneously capture the PK of multiple ADC analytes commonly measured in the clinic. A comprehensive literature review was conducted to collect PK data on MMAE-based ADCs from clinical trials. From each study, PK profiles of total antibody, the ADC, conjugated MMAE, and unconjugated MMAE, were extracted. These data were pooled and dose-normalized to evaluate the generalizability of PK across various ADCs and dose levels. Upon confirming PK generalizability, a generalized PK model for MMAE-based ADCs was developed using the entire dataset. Furthermore, exposure metrics ( and AUC) reported across the range of doses were combined to establish linear relationships between dose and exposure metrics for MMAE-based ADCs. A total of 109 PK profiles from 18 distinct MMAE-based ADCs were gathered. The dose-normalized PK profiles supported the generalizability of PK for MMAE-based ADCs. A generalized PK model was developed, which enabled capturing the PK data for 4 ADC analytes across all collected MMAE-based ADCs. A linear relationship between dose and PK exposure metrics was established, enabling the prediction of typical exposure values across different doses for MMAE-based ADCs. This study comprehensively analysed clinical PK data from different valine-citrulline (vc)-MMAE-based ADCs. The generalized PK model developed here serves as an important tool for a priori prediction of the PK for multiple ADC analytes in clinical settings and lays the foundation for establishing generalized exposure-response and exposure-toxicity correlations for MMAE-based ADCs.

Adaptive adjustment of brightness and blur of the camera for high precision internal parameter calibration

Camera calibration is a prerequisite for many computer vision tasks, such as visual measurement and visual localization. This paper proposes a new method for high-precision calibration of camera intrinsic parameters. By dynamically adjusting image brightness and blur to cope with changes in external lighting conditions and camera working distance, high-precision internal parameter measurement is achieved. This method solves the problems of the traditional camera intrinsic parameter calibration process being cumbersome and susceptible to changes in the placement of calibration boards and fluctuations in external lighting conditions. Firstly, an adaptive exposure adjustment algorithm is proposed to adjust the camera exposure value by statistically analyzing the average gray value of randomly selected rectangular regions on the calibration board, thereby solving the problem of the camera calibration accuracy being affected by overly bright or dark environments. Subsequently, an evaluation criterion and adaptive adjustment strategy for adjusting image blur are proposed. By extracting edge points of feature circles and obtaining the slope of the fitted curve, the relationship between edge sharpness and slope is utilized to adjust the image blur. Finally, the proposed method achieves high-precision semi-automatic calibration. Experimental results demonstrate that the proposed method has significant advantages in terms of correctness, robustness, and flexibility, with an average reprojection error of 0.0167.

Fractional Distribution of Solar UV-B Absorbance on Outdoor Workers within Nsukka Metropolis, South Eastern Nigeria

Ultraviolet radiation is one of the physical concerns of the environment. Several nations have thus moved research attention to this area. This research work aimed at measuring the solar UV-B absorbance on outdoor workers in Nsukka metropolis, South Eastern Nigeria. An LS125 multi probe UV Light Meter with UV- B sensor was used to measure the UV-B irradiance across five study locations representing the various occupations, viz: Barracks (mechanics), Opi (Farmers), Ogige (Traders), Zik’s flat (motor park workers) and Onuiyi (Bricklayers). A UV-Vis spectrophotometer was used to determine the change in the optical absorbance of polymer polysulphone dosimeters. Result shows that UV-B Irradiance was highest at solar noon across the study locations. The dosimeter placed on the head received the highest dose of UV- B radiation at the study locations. The values of the cumulative UV-B exposure of the dosimeters placed on the body parts at the study sites were higher than the occupational exposure limit of 30J/m2 for a 6.5-hour exposure time for both the eye and skin recommended by the International Commission on Non-Ionizing Radiation Protection (ICNIRP). The AIC and BIC values shows that the logarithm regression model outperformed the other models tested. This work therefor sets a reliable baseline data for solar UV-B radiation monitoring in Nsukka, South Eastern Nigeria and also recommend that protective clothing be worn carrying out daily activities during peak solar UV-B radiation hours,

Identification of Hazards and Risk Assessment in the Workplace of PT. Nusantara Traisser Site PT. Vale Indonesia Sorowako, South Sulawesi

The mining industry has a high risk of accidents, thereby prioritizing the understanding of safety and occupational health aspects. This research discusses the potential hazards and risk values for each work area of Nusantara Traisser Ltd. at the site of Vale Indonesia Pte Ltd. in 2023. Potential hazards came from field observations, and risk assessments were conducted by analyzing the probability, exposure, and consequence values of each identified hazard. These values were then adjusted according to the semi-quantitative risk level standards of William T. Fine. This research employed an observational approach using the AS/NZS 4360:2004 method for risk management. The results of the study indicated that the total number of potential hazards identified in the four work areas was 11, each with its respective risk value. The highest risk level reached 300, classified as priority 1, involving the hazard of mining traffic in the Anoa North Ground Training area (Mines HSOR Department) and the Enggano Coal and Sulfur Storage area. The recommended risk controls for each work area include elimination, engineering control, administration, and personal protective equipment (PPE).

Potentially toxic elements pose a threat to environmental quality and human health: The Kumasi Abattoir Ghana in perspective

The environmental and human health risks of potentially toxic elements (PTEs) – iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), lead (Pb), nickel (Ni), and cadmium (Cd), in the Kumasi Abattoir Ghana (KAG) untreated effluent have been investigated. PTEs' spatial variability was analyzed using principal component analysis (PCA). Environmental risk assessments were investigated using three novel indices Effluent Pollution Index (EPI), Effluent Discharge Quality Index (EDQI), and modified Heavy Metal Pollution Index (mHPI), which incorporated eigenvectors from the two PCs. Carcinogenic and non-carcinogenic health risks were evaluated for children and adults using standard methods. The high signal-to-noise ratio (SNR) in the PCA was attributed to PC1 (54.2 %) and PC2 (26.2 %), accounting for 80.4 % of the total variance. The eigenvectors of Cu and Zn (both non-carcinogenic) for PC1 and Mn (non-carcinogenic) and Pb (carcinogenic and non-carcinogenic) for PC2 exerted the most effects. PC1 and PC2 corresponded to the effluent temperature and chemical oxygen demand (COD), respectively. The highest EPIpc1 = 61.20 and EPIpc2 = 46.48 were attributed to Fe. Ni had the lowest values (EPIpc1 = 0.02, EPIpc2 = 0.01). EDQIpc1 = 9.52, EDQIpc2 = 7.30 and mHPIpc1 = 474.97 and mHPIpc2 = 267.94 depicted major environmental threats. These indices corresponded to the effluent nitrate (NO3−). Major health threats emerge through ingestion non-carcinogenic (child = 31.42; adult = 18.88) and carcinogenic risk (child = 8.25 × 10−1; adult = 4.96 × 10−1). The dermal health risks were negligible non-carcinogenic (child = 6.25 × 10−4; adult = 3.91 × 10−4) and carcinogenic (child = 1.36 × 10−6; adult = 8.52 × 10−7). Limited by national exposure values, this study provides scientific evidence of potential dangers associated with PTE exposure in the KAG's effluent. It also serves as a critical bridge between environmental quality and health risk of vulnerable communities, calling for actionable intervention.

Medication Usage Record-Based Predictive Modeling of Neurodevelopmental Abnormality in Infants under One Year: A Prospective Birth Cohort Study.

Early identification of children with neurodevelopmental abnormality is a major challenge, which is crucial for improving symptoms and preventing further decline in children with neurodevelopmental abnormality. This study focuses on developing a predictive model with maternal sociodemographic, behavioral, and medication-usage information during pregnancy to identify infants with abnormal neurodevelopment before the age of one. In addition, an interpretable machine-learning approach was utilized to assess the importance of the variables in the model. In this study, artificial neural network models were developed for the neurodevelopment of five areas of infants during the first year of life and achieved good predictive efficacy in the areas of fine motor and problem solving, with median AUC = 0.670 (IQR: 0.594, 0.764) and median AUC = 0.643 (IQR: 0.550, 0.731), respectively. The final model for neurodevelopmental abnormalities in any energy region of one-year-old children also achieved good prediction performance. The sensitivity is 0.700 (IQR: 0.597, 0.797), the AUC is 0.821 (IQR: 0.716, 0.833), the accuracy is 0.721 (IQR: 0.696, 0.739), and the specificity is 0.742 (IQR: 0.680, 0.748). In addition, interpretable machine-learning methods suggest that maternal exposure to drugs such as acetaminophen, ferrous succinate, and midazolam during pregnancy affects the development of specific areas of the offspring during the first year of life. This study established predictive models of neurodevelopmental abnormality in infants under one year and underscored the prediction value of medication exposure during pregnancy for the neurodevelopmental outcomes of the offspring.

Characterization and health risk assessment of nine polychlorinated biphenyls in settled dust of residential buildings in a Middle Eastern area

Polychlorinated biphenyls (PCBs) are 209 persistent organic compounds with various applications in chemical, electrical and commercial industries. However, there is considerable evidence of environmental accumulation and potential adverse health effects of this compound. In this study, 40 indoor dust samples were randomly taken from Shiraz houses for the analysis of 9 PCB congeners (PCB-18, 28, 31, 44, 52, 138, 153, 189, 194). The dust samples were extracted with 100 ml dichloromethane/n-hexane/acetone in a Soxhlet appliance for 18 h and then analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). The results showed that Σ9PCB were in the range of <dl – 9.31 ng/g and PCB-52, 31 and 28 were the predominant congeners. Moreover, houses with laminate floors had higher Σ9PCBs levels than the houses with ceramic floors. The hazard quotient (HQ) values for children and adults' exposure to 9 PCBs through ingestion route were lower than 1, indicating no adverse non-carcinogenic risk. Also, the incremental lifetime cancer risks (ILCRs) values were lower than 10−6 in low-risk and high-risk scenarios for the both age groups, which showed negligible carcinogenic risks arising from exposure to the analyzed PCBs. More studies focusing on biomonitoring and bioavailability approaches are recommended for future investigation to provide total intake of people to this pollutant from all routes of exposure.

Baseline data and associations between urinary biomarkers of polycyclic aromatic hydrocarbons, blood pressure, hemogram, and lifestyle among wildland firefighters.

Available literature has found an association between firefighting and pathologic pathways leading to cardiorespiratory diseases, which have been linked with exposure to polycyclic aromatic hydrocarbons (PAHs). PAHs are highlighted as priority pollutants by the European Human Biomonitoring Initiative in occupational and non-occupational contexts. This cross-sectional study is the first to simultaneously characterize six creatinine-adjusted PAHs metabolites (OHPAHs) in urine, blood pressure, cardiac frequency, and hemogram parameters among wildland firefighters without occupational exposure to fire emissions (> 7 days), while exploring several variables retrieved via questionnaires. Overall, baseline levels for total OHPAHs levels were 2 to 23-times superior to the general population, whereas individual metabolites remained below the general population median range (except for 1-hydroxynaphthalene+1-hydroxyacenaphtene). Exposure to gaseous pollutants and/or particulate matter during work-shift was associated with a 3.5-fold increase in total OHPAHs levels. Firefighters who smoke presented 3-times higher total concentration of OHPAHs than non-smokers (p < 0.001); non-smoker females presented 2-fold lower total OHPAHs (p = 0.049) than males. 1-hydroxypyrene was below the recommended occupational biological exposure value (2.5 μg/L), and the metabolite of carcinogenic PAH (benzo(a)pyrene) was not detected. Blood pressure was above 120/80 mmHg in 71% of subjects. Firefighters from the permanent intervention team presented significantly increased systolic pressure than those who performed other functions (p = 0.034). Tobacco consumption was significantly associated with higher basophils (p = 0.01-0.02) and hematocrit (p = 0.03). No association between OHPAHs and blood pressure was found. OHPAHs concentrations were positively correlated with monocyte, basophils, large immune cells, atypical lymphocytes, and mean corpuscular volume, which were stronger among smokers. Nevertheless, inverse associations were observed between fluorene and pyrene metabolites with neutrophils and eosinophils, respectively, in non-smokers. Hemogram was negatively affected by overworking and lower physical activity. This study suggests possible associations between urinary PAHs metabolites and health parameters in firefighters, that should be further assessed in larger groups.

Occurrence and exposure evaluation of 2- and 3-monochloropropanediol (MCPD) esters and glycidyl esters in refined vegetable oils marketed in Tianjin of China

2-and 3-monochloropropanediol esters (2-/3-MCPDE) and glycidyl esters (GE) with high toxicity have drawn global concerns due to their widespread occurrence in refined vegetable oils and oil-based foods. In this study, we investigated the contamination level and human health risks of 2-MCPDE, 3-MCPDE and GE in refined vegetable oils marketed in Tianjin of China. Results showed that the concentrations of 2-MCPDE, 3-MCPDE and GE in the 137 vegetable oil samples were in the range of not detected (ND) −6.95 mg/kg, ND-8.39 mg/kg and ND-5.46 mg/kg, respectively. The mean, 50th percentile and 95th percentile concentrations of 3-MCPDE were higher than the corresponding concentration of 2-MCPDE and GE in different types of oils samples. Among the samples analyzed, 29 samples (21.2%) exceeded the maximum levels (2.5 mg/kg) for 3-MCPDE, while 25 samples (18.2%) exceeded the maximum levels (1.0 mg/kg) for GE. The estimated intakes of 3-MCPDE of high consumers of children (7–10 years), adolescents (11–13 years) exceeded the tolerated daily intake (TDI) value of 2 µg/kg bw per day established by EFSA, suggesting a potential concern. The Margin of Exposure (MoE) values for glycidol exposure via vegetable oils consumption in all age groups indicated there is a human health concern.

Научное обоснование среднегодовой предельно допустимой концентрации ванадия пентоксида в атмосферном воздухе по критериям допустимого риска

Relevance of this study is determined by the sanitary-epidemiological legislation of the Russian Federation with stipulated requirements to create hygiene standards for environmental factors ensuring their safety for people. These hygienic standards should guarantee absence of impermissible lifetime health risks. Divanadium pentoxide is a chemical that should be mandatorily regulated in ambient air under long-term exposure due to its wide prevalence and high toxicity. An average annual MPL for divanadium pentoxide was established by using systemic analysis of research literature and regulatory documents. According to selection results, three key epidemiological studies were taken for further analysis. They provided evidence of adverse effects produced by divanadium pentoxide on human health (the respiratory organs in particular) under chronic inhalation exposure. When analyzing a study design, we paid special attention to description of observation groups, values of exposure and nature of its effects, adverse health outcomes caused by exposure to divanadium pentoxide as well as to a type and a value of a point of departure. We calculated a value of the total (complex) uncertainty factor in order to establish an average annual maximum permissible level of the analyzed chemical. As a result, we suggest a scientifically substantiated (among other things, as per permissible health risk levels) average annual maximum permissible level for divanadium pentoxide, which equals 0.0001 mg/m3. This level is safe for human health under lifetime exposure. It is noteworthy that this level corresponds to ‘low uncertainty’, which indicates its high safety for human health.

Scientific substantiation of average annual maximum permissible level of vanadium pentoxide in ambient air as per permissible health risk

Relevance of this study is determined by the sanitary-epidemiological legislation of the Russian Federation with stipulated requirements to create hygiene standards for environmental factors ensuring their safety for people. These hygienic standards should guarantee absence of impermissible lifetime health risks. Divanadium pentoxide is a chemical that should be mandatorily regulated in ambient air under long-term exposure due to its wide prevalence and high toxicity. An average annual MPL for divanadium pentoxide was established by using systemic analysis of research literature and regulatory documents. According to selection results, three key epidemiological studies were taken for further analysis. They provided evidence of adverse effects produced by divanadium pentoxide on human health (the respiratory organs in particular) under chronic inhalation exposure. When analyzing a study design, we paid special attention to description of observation groups, values of exposure and nature of its effects, adverse health outcomes caused by exposure to divanadium pentoxide as well as to a type and a value of a point of departure. We calculated a value of the total (complex) uncertainty factor in order to establish an average annual maximum permissible level of the analyzed chemical. As a result, we suggest a scientifically substantiated (among other things, as per permissible health risk levels) average annual maximum permissible level for divanadium pentoxide, which equals 0.0001 mg/m3. This level is safe for human health under lifetime exposure. It is noteworthy that this level corresponds to ‘low uncertainty’, which indicates its high safety for human health.