Consumption of areca nut and tobacco, often initiated in adolescence, are important causes of oral cancers in India. Areca nut prevention, often subsumed into school tobacco prevention programs, assumes that users are similar. However, differences in gender or age of users could necessitate unique approaches. The study aimed to find if adolescent areca nut-only users are different from tobacco-only users and users of both areca and tobacco. A cross-sectional survey with school-students attending grades 7, 8, 9 was used to compare differences in age, gender, knowledge, and attitudes among areca nut only users, tobacco-only, users of both, and non-users. Of 1909 respondents, 464 (24.3%) used only areca nut, 25 (1.3%) used only tobacco, 177 (9.3%) used both, and 1243 (65.1%) were never-users. Females, overwhelmingly, consumed only areca nut. Users of both substances, in greater proportions, were male, older in age, and more than half believed that tobacco-users had more friends. A third of tobacco-only and users of both substances found it hard to turn down a friend's request to use compared to a fifth of areca-only and non-users. Differences in gender, age, and behavioral determinants such as subjective norms and perceived behavioral control between the different types of users underlines the need for prevention and cessation programs and policies that are specific to and tailored to their unique profiles and needs.