Urmia University Research Articles

Comparison of biofilm production and virulence gene distribution among community- and hospital-acquired Staphylococcus aureus isolates from northwestern Iran

IntroductionThe emergence of antimicrobial-resistant isolates among Staphylococcus aureus and their genetic variations has become a major concern worldwide. The present study aims at comparing the biofilm formation and the genes encoding adhesion molecules in methicillin-susceptible, community- and hospital-acquired methicillin-resistant, vancomycin-intermediate and vancomycin-resistant S. aureus isolates. MethodologyThe current study was conducted on 60 S.aureus isolates, collected at Urmia University of Medical Sciences, Iran, between the years 2014 and 2015. The modified Congo-red agar and Microtiter plate methods were used to determine biofilm production. PCR was used to detect the genes which were associated with a protein family of staphylococcal microbial surface components recognizing adhesive matrix molecules. The data were analyzed using SPSS (IBM SPSS Statistics, version 16). ResultsOf 60 isolates, 57 (95%) were biofilm producers. Unlike the bbp gene, which was only detected in 3 (5%) isolates, the eno and icaD genes were identified as the most prevalent as they were detected in 53 (88.3%) and 50 (85%) of 60 isolates, respectively. The dominant virulotype comprised eight genes (icaA, icaD, clfA, clfB, fnbA, cna, eno, ebpS) in eight isolates, six of which were community-acquired-MRSAs. ConclusionA high percentage of the S. aureus isolates could produce a biofilm which is more common among methicillin-susceptible isolates. The high frequency of eno and icaD genes suggests that these genes may synergistically function in the onset and progression of bacterial colonization and biofilm formation. Meanwhile, this ability may help the bacteria resist the exposure of antibacterial agents and cause severe infections.

Evaluation of human Albumin Use Pattern in a Referral Teaching Hospital

Background: Albumin is generally used in hypovolemic conditions and due to its high cost and complicated manufacturing process, its appropriate use is a vital issue to be considered. The aim of this study was to evaluate the pattern of Albumin prescription in Imam Khomeini teaching hospital in Urmia, Iran. Methods: This study was carried out between December 2014 to December 2015 in the Imam Khomeini hospital, affiliated to Urmia University of Medical Sciences, using pre-designed forms covering demographic data and clinical and laboratory information that was completed by the educated pharmacist on a daily observational basis. Results: A total of 202 patients were selected with the mean age of 55.9±20.5 years, including 53% male patients. The highest prescription percentages were for patients with the diagnosis of Gastrointestinal Cancers (10.9%) while most of the patients were admitted in burn ward (16.3%). Overall 2755 Albumin 20% vials equal to almost 3030 million Rials were used while only 79 (39.1%) of the prescriptions were appropriate. Hypoalbuminemia was responsible for the highest number of inappropriate indications. Conclusion: Our results showed a low percentage of acceptable prescriptions which highlights the necessity for reviewing and supervising the utilization of Albumin in this hospital. J Pharm Care 2019; 7(3): 44-51. Methods: This study was carried out between December 2014 to December 2015 in the Imam Khomeini hospital, affiliated to Urmia University of Medical Sciences, using pre-designed forms covering demographic data and clinical and laboratory information that was completed by the educated pharmacist on a daily observational basis. Results: A total of 202 patients were selected with the mean age of 55.9±20.5 years, including 53% male patients. The highest prescription percentages were for patients with the diagnosis of Gastrointestinal Cancers (10.9%) while most of the patients were admitted in burn ward (16.3%). Overall 2755 Albumin 20% vials equal to almost 3030 million Rials were used while only 79 (39.1%) of the prescriptions were appropriate. Hypoalbuminemia was responsible for the highest number of inappropriate indications. Conclusion: Our results showed a low percentage of acceptable prescriptions which highlights the necessity for reviewing and supervising the utilization of Albumin in this hospital. J Pharm Care 2019; 7(3): 44-51.

<p>Syndromic Surveillance System for MERS-CoV as New Early Warning and Identification Approach</p>

This commentary presents a novel outlook for public health authorities in the affected countries to detect and respond quickly to the emerging public health threats such as Middle East respiratory syndrome coronavirus (MERS-CoV). Implementing an innovative electronic surveillance system called syndromic surveillance system is essential for global health security.

Iranian women’s experiences of infertility: A qualitative study

BackgroundThere are concerns and diverse experiences related to infertility and childlessness. The lived experience of infertile people from various cultures needs to be explored.ObjectiveThe aim of this qualitative study was to explore Iranian women experiences of their infertility.Materials and MethodsThe data comprised interviews about fertility issues in the Persian language with eighteen women, aged 17-45 yr old, who agreed to be interviewed at the Mottahari Infertility Treatment Clinic, affiliated to the Urmia University of Medical Sciences about their fertility problems. They were approached by the researchers at the time of their first visit. The verbatim transcribed interviews were analyzed using deductive conventional content analysis.ResultsThe experiences of the informants were conceptualized into four major themes: 1) Shock (subthemes: Disbelief and Denial); 2) Reaction (subthemes: Distress, Guilt, Loss of self-esteem and Sexual reluctance); 3) Processing (subthemes: Internal processing, Avoidance, Marriage at risk, External processing, Stigma caused by the family and Stigma caused by the community) and 4) Reorientation (subthemes: Forgetting, Marriage to saving marriage and Sexual consent).Conclusion Infertility can be a challenging condition. Considering that infertility-related issues affect Iranian women more contextual factors is necessary. So, culturally sensitive and gender specific protocols are suggested to provide suitable and about culturally sensitive and gender-specific protocols is a necessity in order to provide suitable care to infertile women.

Prediction and validation of terramechanics models for estimation of tyre rolling resistance coefficient

This research focuses on prediction of the rolling resistance coefficient of an agriculture tyre using finite element analysis (FEA) technique, and Bekker and Wismer-Luth models. The tyre-soil interaction is modelled using FEA and smoothed-particle hydrodynamics (SPH) techniques in Visual Environment's PAM-Crash software and validated based on experimental results. A single-wheel tester along with a controlled soil bin at Urmia University, Iran is used to investigate the effect of a tyre's multi-pass and vertical load on the rolling resistance coefficient of an off-road tyre. In order to calculate the rolling resistance of Bekker model, a bevameter device is installed on a carriage moving on clayey-loam soil and a digital penetrometer is used for obtaining the output of Wismer-Luth model. Analysis of experimental data shows that rolling resistance coefficient increases as the vertical load increases and decreases with each pass of tyre. These results are used to compare and evaluate the above-mentioned methods. The results of this study will be used in further research on the interaction between a tyre and soil.

A research study of relationship between strategic human resource management and employee innovation (from the employee's perspective, Islamic Azad University of Urmia)

Strategic human resource management is an approach to the formulation and implementation of human resource strategies; in such a way that it blends with the strategies of the organization and to assist it to achieve its objectives. In fact, the nature of the strategic management of human resource has a conceptual aspect and a general attitude about how to achieve fusion or combination of organization strategies and human resource strategies, long term benefits to where human resources should go and how to get there and finally the way of formulation and implementation of strategies related to human resources, also, innovation is important for many companies and organizations. Because it can provides a sustainable competitive advantage for them. Many organizations that face many problems in the competitive environment will be able to get rid of these problems. The population in this study consists of all employees and managers of Islamic Azad University of Urmia, and according to the official statistics, 213 patients were considered as the entire population of this study and according to Cochran's formula the sample size of 137 was determined and 130 questionnaires were distributed among the sample and the data from the questionnaires were analyzed using Spss 18 software and the results of the study proved a significant relationship between the intended HRM strategies to demonstrate staff innovation, therefore the research hypothesis were confirmed.

Protective disciplinary exchange: A qualitative study into nurse managers' supportive strategies for nursing error management

Background: Understanding nurse managers' supportive strategies for managing nursing errors can facilitate the improvement of nursing care quality and patient safety. Objectives: This study aimed to explore nurse managers' supportive strategies for nursing error management (NEM). Methods: This descriptive qualitative study was conducted on twenty nurse managers and two nurses purposively recruited from teaching hospitals affiliated to Urmia University of Medical Sciences, Urmia, Iran. The data were collected via in-depth semistructured interviews and concurrently analyzed via conventional content analysis. Results: Nurse managers' supportive strategies for NEM were overlooking nurses' errors to promote their obedience, prioritizing nursing care measures to reduce errors, error prevention training rounds during shift handover instead of error reporting, and alternative disciplinary measures instead of error reporting. These strategies were conceptualized as protective disciplinary exchange. Conclusion: Protective disciplinary exchange denotes that nurse managers prefer to manage nursing errors with flexibility. This situational communicative strategy helps nurse managers protect their staff resources and maintain their positions.

Psychometric Properties of the Iranian version of Champion's Revised Health Belief Model Scale for Breast Cancer screening.

Background:Women's beliefs regarding breast cancer and its screening approaches were considered antecedents of their behavioral changes. Understanding of these beliefs in women requires a valid and reliable instrument. The present study seeks to translate the English version of the Champion's Revised Health Belief Model Scale (CRHBMS) into the Persian language and assess its psychometric properties.Materials and Methods:The study was conducted on 334 students at Urmia University of Medical Sciences, Iran, 2016. The 57-item CRHBMS was translated to Persian language, back translated, and tested. To test the face and content validity of the Persian version; item analysis, Content Validity Ratio (CVR), and Content Validity Index (CVI) were applied, respectively. Construct validity of the Persian scale was performed by Exploratory and Confirmatory Factor Analyses (EFA, CFA) using Kaiser-Meyer-Olkin and Bartlett's tests in SPSS 16 and LISREL8.72 software. The reliability of the translated scale was evaluated using Cronbach's alpha and test-retest approaches.Results:In the EFA, eight factors were extracted concerning breast cancer screening, and each item was loaded on its specific factor. These factors were self-efficacy, health motivation, benefits-mammography, benefits-Breast Self-Examination (BSE), barriers-mammography, barriers-BSE, susceptibility, and severity. The final 42-item scale was confirmed by the CFA, and all goodness of fit indices showed a proper fit of the model. Cronbach's alpha coefficient and test-retest correlation of the subscales ranged from 0.72–0.89 and 0.67–0.93, respectively.Conclusions:The study suggests that the Persian version of CRHBMS is a feasible scale for evaluating women's health beliefs regarding breast cancer and its screening behaviors.

Relationship with Emotional Intelligence and General Health among Male Smoker Staff in Urmia University of Medical Sciences

Introduction: One of the important factors in determining success in life is emotional intelligence. It could be considered as a protective factor against health threatening behaviors, including smoking. Considering the effect of emotional intelligence on the health of people and the amount of smoking in smokers, the present study aimed to investigate the relationship between emotional intelligence and general health in the male smokers.Methods: In this descriptive-correlational study, 350 male smokers who were working in Uremia University of Medical Sciences were recruited, using convenience sampling. The instruments used in this study were demographic information questionnaires, Cyberia Shrink standard questionnaire, and 28-Question General Health Questionnaire (GHQ-28).Results: The mean score (SD) of emotional intelligence and the mean score (SD) of general health were 110.26 (16.24) and 23. 60 (13.27), respectively. There was a significant negative relationship between emotional intelligence and general health scores.Conclusion: Individuals with higher emotional intelligence scores had a better physical and mental health status. Therefore, teaching emotional intelligence can increase physical and mental health of the individuals through reducing risky behaviors.

Exergoeconomic evaluation of a system driven by parabolic trough solar collectors for combined cooling, heating, and power generation; a case study

An exergoeconomic assessment of a combined cooling, heating, and power generation system is conducted for summer air conditioning for the school of engineering at Urmia University in Iran. The proposed application comprises of parabolic trough solar collectors integrated with an organic Rankine cycle and two single-effect absorption chillers. The novelty of the paper relies on considering the real energy load and solar radiation for the exergoeconomic analysis. Hence, three solar radiation operational modes are simulated, which includes low (solar mode), high (solar and storage mode), and no radiation (storage mode) during the day. The effects of the three vital parameters, including Day numbers, organic Rankine cycle pump inlet temperature, and organic Rankine cycle turbine inlet pressure on several variables are examined. The results illustrated that the highest cooling, heating, and electrical power loads of the building during summer time are 896.9 kW, 228.5 kW, and 1500 kW, respectively. Furthermore, the cost per unit exergy of the generated power for the above-mentioned modes are 11.44 $/GJ, 10.27 $/GJ, and 15.47 $/GJ, respectively. It was concluded that these values decrease by 16.4, 18.4, and 11.9% point as a result of the overall system establishment.

Inverse Dynamic Data Envelopment Analysis for Evaluating Faculties of University with Quasi-Fixed Inputs

Like other organizations, universities must evaluate their performance to identify areas for improvement. Although the different aspects of a university are considered for evaluation, the research section is deemed to be the most important and is where the necessity of the performance evaluation is most salient. In this study, the relative efficiency of the sub-units of several faculties of the university has been investigated through dynamic data envelopment analysis (DDEA) and inverse DDEA (IDDEA). The capability of traditional DEA to differentiate between efficient and non-efficient units decreases as the ratio of the number of inputs and outputs to the number of decision-making units increases. To remove this limitation by adding intermediate constraints between stages, a dynamic form of the method was applied in this research. The paper provides distinctions between the faculties as well as sensitivity analysis of the inputs/outputs of each faculty. The proposed IDDEA is implemented to scrutinize the changes in the input and output levels. The proposed approach is output-oriented to account for the homogeneity of faculties and their subordination under a specific unified management policy. A case study of Urmia University is used to demonstrate the proposed approach.

The economic efficiency of clinical laboratories in public hospitals: A case study in Iran.

IntroductionClinical laboratories are identified as one of the most important and expensive units of the health system. Therefore, it is essential to pay attention to these units' cost efficiency. This study purpose was to evaluate the economic efficiency of hospitals' laboratory units affiliated to Urmia University of Medical Sciences (UMSU), in order to assess their performance.MethodsThis research was a descriptive‐analytic study that was accomplished in 2017. The statistical population of the study included all of the hospitals' clinical laboratories affiliated to UMSU. Moreover, DEA method and Deap2.1 software were used to analyze data. In this study, technical and allocative efficiencies of the studied laboratory units were also calculated in addition to the determination of the economic efficiency of the laboratories.ResultsThe average economic efficiency of clinical laboratories calculated by DEA in 2017 was 0.676. This value was lower than the allocative and technical efficiency scores, which indicates that these units could attain full efficiency by reducing their costs without having any effect on output values. Moreover, about 14 percent of the clinical laboratory units were economically efficient. In addition, it is noteworthy to state that, from total of university hospital laboratories, only three hospitals had no economic excess or deficiency values of inputs.ConclusionConsidering that 76% of laboratory units have not been economically efficient, it is necessary for the laboratory managers to consider optimum allocating of resources, with respect to the cost of laboratory equipment and inputs in order to increase their units' economic efficiency.

Thermodynamic investigation of a new combined cooling, heating, and power (CCHP) system driven by parabolic trough solar collectors (PTSCs): A case study

A new solar-based, combined cooling, heating, and power system is designed and developed for the school of engineering at Urmia University in Urmia, Iran. The proposed arrangement consists of a solar subsystem with parabolic trough solar collectors, an organic Rankine cycle, two heating processes, and two single-effect absorption chillers. The system is thermodynamically studied for the summer air conditioning requirements, considering genuine energy demand and variable solar radiation in three different operational modes (solar, solar and storage, and storage modes). The influences on the system performance are assessed of varying three main variables including the number of days, organic Rankine cycle pump inlet temperature, and organic Rankine cycle turbine inlet pressure. The results demonstrate that the highest cooling, heating and electrical loads in the summer air conditioning are 896.9 kW, 228.5 kW, and 1500 kW, respectively. The energy load is provided by employing 449–1625 number of PTSCs throughout the year. Furthermore, for summertime the energetic and exergetic analyses reveal that the energy efficiency of the system in the solar mode, solar and storage mode, and storage mode is found to be 98%, 47.3%, and 98%, respectively. Accordingly, the exergy efficiencies were equal to 17%, 8.3%, and 17%.

Irrigation scheduling of maize based on plant and soil indices with surface drip irrigation subjected to different irrigation regimes

A study was conducted on a research farm at Urmia University under drip irrigation in order to schedule the irrigation of maize based on plant indices: crop water stress index (CWSI) and relative water content (RWC) and soil indices: soil water (SW) and soil penetration resistance (Q) in climatic conditions of Urmia region in Iran. This study was conducted in the form of randomized complete block design with four irrigation levels including two levels of deficit irrigation (I1) (Crop water requirement (CWR) of 0.5) and I2 (0.75CWR), a full-irrigation level of I3 (1.0CWR) and an over-irrigation level of I4 (1.25CWR) with three replications. I4 treatment for air-filled porosity was considered in the soil. For irrigation scheduling, lower and upper baseline and CWSI equations for I1, I2 and I3 treatments were calculated during plant growth period. Using the extracted baselines, the mean CWSI values during maize growth season for I1, I2 and I3 treatments were calculated to be 0.53, 0.44 and 0.28 respectively. The threshold limit of water stress index of I3 treatment was the basis of irrigation scheduling. Then, relationships were provided for determining the irrigation time using CWSI in Urmia climate for three maize growth stages. In addition, among soil and plant indices which were simultaneously measured at maximum stress hour were used as a complementary indicator to eliminate CWSI constraints. Using the regression relationships extracted between the indices, the water status of plant can be determined by only measuring the canopy temperature (Tc) without measuring the RWC, SW and Q. It should be noted that in the region of Urmia, the critical values of the difference between the Tc and the air temperature, Q and SW for maize were respectively 1.5 °C, 3.6 MPa and 0.27 cm3 cm−3 (matric potential of 8900 hPa).

Trypanosoma evansi and “Candidatus Mycoplasma haemolamae” Co-Infection in One-Humped Camel (Camelus dromedarius) from the Northwest of Iran: A Case Report

A 4-year-old male one-humped camel (Camelus dromedarius) was referred to Veterinary Teaching Hospital of Urmia University, Iran in 2017 with anorexia, weakness, depression and pale mucosa. Decreased red blood cell count, packed cell volume and hemoglobin concentration were detected by complete blood cell count. In Giemsa-stained peripheral blood smears Trypanosoma spp. trypomastigotes scattered between erythrocytic spaces and Mycoplasma-like organisms were observed attached to the surface of erythrocytes. Species-specific PCR assay confirmed T. evansi and Candidatus Mycoplasma haemolamae (CMhl) co-infection. Administration of diminazene aceturate, oxytetracycline 20%, flunixin meglumine and phosphorus-vitamin B12 were not effective in treatment. Hemoplasmosis should be considered as an important differential diagnosis of conditions associated with hemolytic anemia in camel.

Inequality Assessment of Hospital Resources Distribution in West Azarbaijan Province Using Economic Indicators, Before-After Health System Reform plan

Background: Equity in access to health care services is one of the main goals of health systems, so that inequality in the geographical distribution of health resources will make it difficult for individuals to access the health care facilities. This study aimed to determine the distribution status of hospital resources and inequality coefficient in the West Azarbaijan province before and after implementation of the health system reform plan. Methods: This cross-sectional and descriptive-analytic study aimed to investigate inequality in the distribution of health resources in cities of West Azarbaijan province before and after health system reform plan using concentration ratio and Hall Tiedman indices. The required data for estimating these indices were the number of specialist physicians and hospital beds, which were extracted from the data base of treatment deputy in Urmia University of Medical Sciences. Data analysis was conducted by Excel software. Results: The results indicated a high spatial concentration in distribution of the health resources in the province, so that fixed beds and specialist physicians were more concentrated in the capital city of province; Urmia. Moreover, inequality in distribution of the resources in cities of the province was highly related to population. Comparisons of the results before and after the health system reform plan showed that the distribution of fixed beds and specialist physicians had decreasing and increasing trends, respectively. Conclusion: The results showed that inequality in distribution of the hospital beds was intensified after implementation of the health reform plan. Furthermore, distribution of specialist physicians after the reform plan, despite its improvement, was not according to the population distribution. Therefore, inappropriate distribution of the above-mentioned resources should be readjusted by adopting redistributive policies.

Association of hip osteoporosis with pattern of proximal femoral fractures

Introduction: Proximal femoral fractures account for a large number of hospitalization cases among the elderly patients. The proximal femoral fractures pattern based on intra-articular or extra-articular could affect the treatment options and induce several complications. The aim of this study is to evaluate the relationship between the severity of osteoporosis and pattern of proximal femoral fractures among elderly patients. Methods: In this cross-sectional study, 83 patients over than 65 years old were enrolled from 2014 to 2018 in the orthopedic department of Urmia University of Medical Sciences, Urmia, Iran. Bone mineral density (BMD) was determined by dual energy x-ray absorptiometry (DXA) at the time of hospitalization. Vitamin D level was also measured. Finally, the mortality rate was determined in 12-month follow-up after the operation. Results: In this study, 83 patients with proximal femoral fractures including 60 cases (72.3%) with extra-articular fractures and 23 cases (27.7%) with intra-articular fractures were investigated. The mean vitamin D level of these two groups [patients with intra-articular fracture (34.4 ± 24.7 nmol/l) and extra-articular fracture (11.3 ± 5.4 nmol/l)] was significantly different (P = 0.020). A significant difference was also observed in the bone densities (based on T-score) of these two groups (P < 0.001). The patients’ mortality rate was significantly different and it was higher in patients with extra-articular fracture (23.0%) compared to those with intra-articular fracture (17.3%) (P = 0.020). Conclusion: In the case of elderly patients, the hip bone density and vitamin D levels play a decisive role in predicting the pattern of proximal femoral fractures. It was also associated with increased mortality among the elderly patients.

The effect of study preparation on test anxiety and performance: a quasi-experimental study.

Background: Health care education is an important issue in the development of countries, and student’s academic achievement plays an important role in this respect. Test anxiety can affect the academic performance of students. This study aimed to investigate the effect of study preparation on test anxiety and performance of public health students.Methods: This quasi-experimental study investigated the effect of study preparation on reducing test anxiety and improving the performance of public health students at Urmia University of Medical Sciences, Urmia, Iran, in the academic year 2016–2017.All second- and third-year bachelor’s students in public health major were assigned into the intervention (n=20) and control groups (n=25). The assignment was based on the study preparation items and the defined benchmark.Data on general stress and test anxiety were collected by subjective self-assessment via paper-and-pencil surveys in the first week of the semester and before the final exam, respectively.Results: No significant difference was found in the level of general stress between the two groups at the beginning of the semester (p=0.55) based on the study preparation items. The level of test anxiety in the intervention group (47.90) was lower than in the control group (34.64) at the end of the semester (p=0.001). The mean value of exam scores was higher in the intervention group (p=0.015).Conclusions: The intervention reduced the level of test anxiety and improved the performance of students. Faculty members and heads of the departments should help students learn about the study preparation over the semester with engagement in learning-oriented approaches and class activities.

Neutrophil-to-lymphocyte ratio in patients with gram-negative sepsis admitted to intensive care unit.

Several studies have investigated the role of Neutrophil to Lymphocyte Ratio (N/L ratio) in the early diagnosis of infection, which had different results. We assessed this ratio in early diagnosis of Gram-negative sepsis admitted to ICU. This cross sectional study was approved by ethics committee of Urmia University of Medical Sciences and conducted during 2015. All patients with gram negative sepsis admitted to general intensive care unit (GICU) were enrolled. Demographic characteristics, APACHE II score, duration of mechanical ventilation and ICU length of stay, average neutrophil, lymphocyte count, and their ratio on the first, second and third day of hospitalization, and mortality were recorded. P < 0.05 was significant. One hundred and thirty nine patients were studied during one year with mean age 68.29 ±17. 4 years. 136 patients received mechanical ventilation with mean 13.85 ±2.07 days. The mean white blood cells count on the first day of hospitalization was 11776.04±5789.60,and on the second and third days was 12446±2101.16 and 13241.01 ± 7077.17, respectively. The ratio of neutrophil to lymphocyte on the day of hospitalization was 11.38±1.02. This ratio on the second and third days was 11.98±0.99 and 12.94±1.3, respectively. Furthermore, 46.8% of patients died. According to the T-test, significant difference was seen between two groups in term of APACHEII score, count of neutrophil, WBC and N/L ratio on the second and third days (p < 0.05). Blood cell analysis and N/L ratio can be used as a predictor for severity of gram negative sepsis along with other diagnostic procedures.

Do Fertilizers and Irrigation Disruption Change Some Physiological Traits of Safflower?

To investigate the effects of nanofertilizers and biofertilizers on the morpho-physiological and biochemical traits of safflower under full irrigation and water deficit stress, this study was carried out as a split-plot experiment based on a Randomized Complete Block Design with three replications at Urmia University in 2015. The main plot was full irrigation (control) and irrigation disruption at heading, flowering, and grain filling stages. Fertilizers, including control (without fertilizer), biofertilizer, water spray, foliar application of nanofertilizers, chemical fertilizers, and combined application of fertilizers, were assigned to the subplot. Plants under full irrigation and combined fertilizers had maximum height and chlorophyll a, whereas the lowest ones were obtained in irrigation disruption at the heading stage and control treatments. The maximum oil content (28.41%) was detected in irrigation disruption at the grain filling stage and nanofertilizer treatment, the lowest (21.96%) was obtained at irrigation disruption at the flowering stage and water spray treatment. The highest proline (397.21 µg g−1 fresh leaf) was found in irrigation disruption at the grain filling stage and water spray treatment, and the lowest (154.68 µg g−1 fresh leaf) was obtained at full irrigation and water spray treatment. Irrigation disruption at the heading stage and control treatments decreased carbohydrate content of fresh leaves by 86.54% compared to full irrigation and the combined fertilizers treatment. Irrigation disruption increases saturated fatty acids (palmitic and stearic acid) and decreases vitamin E and linoleic acid. The combined application of fertilizers significantly increased safflower oil quality. Overall, concerning the obtained highest oil percentage (28.41%), irrigation disruption during grain filling reduced water consumption and application of combined fertilizer via improving oil quality, so it is recommended to farmers.