In high-altitude areas, the air is thin and the atmospheric pressure is low, which can affect the performance of centrifugal fans and aerodynamic noise. In this paper, steady and unsteady simulations of a centrifugal fan flow field are performed at altitudes of 0, 1000, 2000, 3000, 4000, and 5000 m, and the Ffowcs Williams-Hawkings equation is used to predict the aerodynamic noise of the fan. The results indicate that the tonal and broadband noise generated by the fan decrease with increasing altitude, and the A-weighted sound pressure level of each frequency band of the fan decreases when the air volume is held fixed. The maximum sound power level Lwmax, sound pressure pulsation interval, and total noise sound pressure level Lp decrease linearly with increasing altitude. For every 1000 m increase in altitude, Lwmax and Lp decrease by 0.45 dB and 1.05 dB respectively. The fan noise characteristics, performance parameters, and human auditory perception are the main factors that affect the establishment of fan noise standards in high-altitude areas.