Unpleasant Feelings Research Articles

EVALUATION OF ANALGESIC ACTIVITY OF SHOREA ROBUSTA RESINS

Shorea robusta (Sal), an important traditional Indian medicinal plant used in various ailments and rituals and the indigenous use of the resin of this plant as a medicament for treatment of various inflammatory conditions is well documented in literature. In the present study, ethanolic extract of S. robusta resin (SRE) was evaluated for its analgesic activity by making use of different central and peripheral pain models. The phytochemical studies have shown the presence of many secondary metabolites belonging to terpenoids, flavonoids, carbohydrate, lignans, phenols and sterols. Crude extracts and isolated compounds from Shorea robusta show a wide spectrum of pharmacological activities, such as anti-inflammatory, anti- obesity, antibacterial, wound healing, anti-pyretic & analgesic activities. Many studies have provided evidence for various traditional uses. The present review on its botany, traditional uses, pharmacological activities and phytochemistry which provides preliminary information for further studies for this potential medicinal plant. Pain is an unpleasant sensation and emotional experience linked to tissue damage. Pain occurs when something hurts, causing an unpleasant or uncomfortable feeling. The nearness of pain implies that something isn't right. Each individual is the best judge own pain. Pain of any origin comprises an individual’s life. The analgesic activity of SRE was assessed by employing different Materials and Methods: pain models such as, i) hot plate and tail flick tests for central analgesia.

The Relationship between the Brain Behavioral Inhibition and Activation Systems (BIS/BAS) with Chronic Fatigue Syndrome among Employees of Technical and Vocational Office of Ilam

Introduction:Fatigue is an unpleasant mental feeling that has also been shown to decrease physical and mental performance, The aim of this study was to examine the relationship between brain-behavioral systems and chronic fatigue syndrome employes Technical and Vocational Office of Ilam. Materials and methods: the aim of this study is based on the purpose of the applied research and based on the way data collection is descriptive research. the research community includes all the technical and professional employees of the city of ilam in 2019. from the above mentioned community, 120 people were selected from available sampling method . then the questionnaire was conducted with chronic fatigue questionnaire and behavioral mental systems questionnaire. to analyze the hypotheses, pearson correlation method and regression were used. Results: According to the research results, there is a positive and significant relationship between driving and chronic fatigue at the level (P = 0.000 r = 0.447). There is a significant negative relationship between entertainment search and chronic fatigue at the level (r = 0.321, p = -000). There was a positive and significant relationship between reward response and chronic fatigue at the level (P = 0.004, r= 0.264). There is a positive and significant relationship between behavioral inhibition and driver at the level (P = 0.004, r = 0.244). There is a positive and significant relationship between driver and response (P = 0.004, r = 0.354). Driver scales, entertainment search, reward response, and behavioral inhibition predict 13.5% of the variance of chronic fatigue. Conclusion: Therefore, it is concluded that there is a significant relationship between behavioral brain systems and chronic fatigue. Therefore, it is important to pay attention to the brain-behavioral systems as an effective factor in chronic fatigue

Mental Resilience and Coping With Stress: A Comprehensive, Multi-level Model of Cognitive Processing, Decision Making, and Behavior.

Aversive events can evoke strong emotions that trigger cerebral neuroactivity to facilitate behavioral and cognitive shifts to secure physiological stability. However, upon intense and/or chronic exposure to such events, the neural coping processes can be maladaptive and disrupt mental well-being. This maladaptation denotes a pivotal point when psychological stress occurs, which can trigger subconscious, “automatic” neuroreactivity as a defence mechanism to protect the individual from potential danger including overwhelming unpleasant feelings and disturbing or threatening thoughts.The outcomes of maladaptive neural activity are cognitive dysfunctions such as altered memory, decision making, and behavior that impose a risk for mental disorders. Although the neurocognitive phenomena associated with psychological stress are well documented, the complex neural activity and pathways related to stressor detection and stress coping have not been outlined in detail. Accordingly, we define acute and chronic stress-induced pathways, phases, and stages in relation to novel/unpredicted, uncontrollable, and ambiguous stressors. We offer a comprehensive model of the stress-induced alterations associated with multifaceted pathophysiology related to cognitive appraisal and executive functioning in stress.

Research advances of studies on involvement of the anterior cingulate cortex involved in acupuncture-induced amelioration treatment of affective pain

As an unpleasant subjective feeling and emotional experience, pain has a negative impact on the physical and mental health of patients. In the early years, the research concerning pain mostly focused on the sensory-discriminative component. With the development of modern medicine, people found that the generation of affective-emotional component of pain has its unique physiological mechanism, and thus carried out a lot of in-depth research. The anterior cingulate cortex (ACC) is the main brain area activated by affective pain, and the regulation of acupuncture on pain aversion is mainly related to it. The mechanism includes various signal pathways, such as extracellular regulated protein kinases-mitogen activated protein kinase-cAMP-response element binding protein pathway, adenylate cyclase 1 protein kinase Mζ- glutamate receptor 1 pathway, contains many biomolecules, such as opioid receptors, neuropeptide S and its receptor, and refers to microglia at the cellular level. This article reviewed the neural mechanism of ACC involved in affective pain and the role of acupuncture played in this process.

The clone devaluation effect: A new uncanny phenomenon concerning facial identity.

Technological advances in robotics have already produced robots that are indistinguishable from human beings. This technology is overcoming the uncanny valley, which refers to the unpleasant feelings that arise from humanoid robots that are similar in appearance to real humans to some extent. If humanoid robots with the same appearance are mass-produced and become commonplace, we may encounter circumstances in which people or human-like products have faces with the exact same appearance in the future. This leads to the following question: what impressions do clones elicit? To respond to this question, we examined what impressions images of people with the same face (clone images) induce. In the six studies we conducted, we consistently reported that clone images elicited higher eeriness than individuals with different faces; we named this new phenomenon the clone devaluation effect. We found that the clone devaluation effect reflected the perceived improbability of facial duplication. Moreover, this phenomenon was related to distinguishableness of each face, the duplication of identity, the background scene in observing clone faces, and avoidance reactions based on disgust sensitivity. These findings suggest that the clone devaluation effect is a product of multiple processes related to memory, emotion, and face recognition systems.

THE SERVICE ENCOUNTER IN HIGHER EDUCATION INSTITUTIONS: A SYSTEMATIC LITERATURE REVIEW

This paper reviews existing literature on the service encounter in higher education institutions. It aims to analyse and provide more insight on the term service encounter, identify dimensions, the types of service encounter and how the service encounter is evaluated. The service encounter (SE) is a critical aspect of the service delivery process. It is used to determine whether the service delivered has been satisfactory or dissatisfactory. Furthermore, the service encounter offers an opportunity for the service provider to demonstrate his or her ability to offer a remarkable experience. However, it has been proven that many service providers do not take advantage of the service encounter to create student satisfaction. As a result, many encounters have left marks of unpleasant and negative feelings on the student. In higher education institutions, the service encounter helps both students and academicians communicate and understand the needs of either party. This study adopted a systematic review of the literature using several academic databases. A plethora of studies on the service encounter were reviewed from several academic databases but only 50 articles published from 1984 to 2018 were cited in this study. A descriptive analysis was used to highlight the classification of the sources used, the number of articles cited in this study and the year when the articles were published. The study identified several definitions of the service encounter and also found that there are several dimensions and types of the service encounter. The divergent views that emanate from these findings stem from the fact that there is a growth in literature and the body of knowledge on the service encounter in different sectors of the economy. The findings of this study could assist academics and practitioners to have a deeper understanding of the service encounter. Such an understanding is very critical in addressing the needs of students and other stakeholders of higher education institutions. Moreover, it can help faculty members and institutional managers deal with moments of truths which if properly managed can facilitate the realisation of student expectations and ultimately, satisfaction. This study further provides a basis for future research using the available service encounter evaluation tools or instruments.

Differences In The Level of Work Anxiety on Contract Teachers

Anxiety is an emotional condition that has the characteristics of physiological, unpleasant tense feelings, and a feeling of worryng that something bad will happen. The things that are worried about health, social relationships, and career. Everyone must experience anxiety, no exception for someone who works as a contract teacher. Uncertainty about their future status and the demands of life are becoming some of the main factors causing anxiety. This study aims to determine the differences in the level of work anxiety on the contract teachers of SMA Seminari St. Rafael Kupang and SMA Negeri 3 Kupang city. This type of research is about quantitative research. The sample size is 45 contract teachers who are willing to fill out the questionnaire scale. The variables studied were tested using the independent sample t test to determine the differences in the level of work anxiety on the contract teachers of the Seminary St. High School Rafael Kupang and SMA Negeri 3 Kupang City. The test results of the Independent sample T-test stated anxiety between the contract teachers of St. Seminary Senior High School Rafael Kupang and SMA Negeri 3 Kupang city, there is no significant difference between. This is obtained from the sig (1-tailed) result of (0.086) (p> 0.05) so that H0 is rejected, meaning that there is no significant difference in work anxiety between the contract teachers of the Seminary St. High School. Rafael Kupang and SMA Negeri 3 Kupang City. Therefore, there is no difference in job anxiety between public and private contract teachers.

THE ILLNESS EXPERIENCE IN HYPERTENSION PATIENTS WITH LOW SOCIOECONOMIC STATUS

Hypertension is one type of disease that is usually experienced by adults, where arteries have excessive pressure, which is above 140 mm Hg for systolic and diastolic 90 mm Hg. Hypertension is not only a physical experience, but also needs to be understood as a psychological and social experience. Health is a social problem because it is related to how a person finances his health and access appropriate health facilities. The purpose of this study was to obtain psychosocial dynamics in the experience of hypertension in patients with low socioeconomic status. This study used a qualitative method with an Interpretative Phenomenological Analysis (IPA) approach through semi-structured interviews. Three participants involved were female, aged 30 to 45 years, and had more than one year suffered from hypertension. This study found six superordinate themes that focused on perceptions of causes, perceptions of hypertension, unpleasant feeling, social resources, improvement efforts, and health development.

The Burnout Level of Beginner Athlete

Burnout is a psychological syndrome that has the main characteristics of emotion fatigue, depersonalization, and a decrease in achievement. This condition of burnout can arise when they have little free time for their lives. In the end, they concerned will feel unpleasant feelings an increasingly stressed when confronted again by the same activity continuously. As a beginner athlete must feel that the sport is fun, if not it will slowly show symptoms of burnout that can affect the development of the novice athlete. If not, they will slowly leave all the activities carried out so far. This study, using a questionnaire as the main instrument to collect data. The questionnaire used was a closed questionnaire and was distributed to 100 beginner athlete from 10 sports specialisation of East Java. From the questionnaire collected, data obtained of 45% of athlete experienced symptoms of low burnout level and 55% experienced symptoms of moderate burnout level. Burnout can be overcome in 5 ways namely increasing self awareness, balancing breaks and activities, choosing activities that are in accordance with the plan, seeking support from the immediate environment, and practicing mental training techniques

No Words To Say It: Trauma And Its Aftermath.

Trauma survivors suffer from unmediated access to primal undifferentiated positions of the psyche. This access, unmediated by symbolic representation, but represented in the body, disrupts the normal trajectory of development and of relationship. Survivors have no words to communicate this experience. Without words, trauma torments them, because it cannot be borne, grieved, and released. Without access to the usual defenses against unpleasant feelings and ideas, survivors are left isolated and confused, unable to enjoy their lives. These primal states are an aftermath of trauma resistant to treatment because they are outside the symbolic positions of the mind. A clinical example is used to demonstrate the loss of language during breakdown and the function action serves in analytic sessions.

Non-pharmacological methods used in coping with restless leg syndrome (RLS): A systematic review

Restless leg syndrome (RLS) is a sensory-motor problem characterized by an uncomfortable and unpleasant feeling that causes a strong and irresistible desire to move the legs, often during periods of inactivity during sleep. Published full-text studies including non-pharmacological interventions used in the management of restless leg syndrome constitute the data of the study. Data were collected from MEDLINE-Pubmed, Science Direct, CINAHL electronic databases. As a result of the search, a total of 10,453 articles were reached. The study sample included quasi-experimental, experimental, or randomized controlled trials, which were published in English, with non-pharmacological interventions used to cope with restless leg syndrome, with full text available without any year limitation. Therefore, the sample consisted of 25 research articles. Non-pharmacological interventions discussed in this study are acupuncture, cognitive behavioral therapy, yoga, exercise, sleep hygiene training, near-infrared light therapy, vibration, and massage techniques. In our systematic review, it was found that non-pharmacological methods used to cope with RLS reduce RLS symptoms, RLS severity and mental health problems (depression, anxiety, stress, etc.), and increase quality of life and sleep quality. However, most of the studies we have reviewed are not randomized controlled studies and the sample group of most of them is small. Therefore, their results do not constitute sufficient evidence. In our study, it was recommended to conduct randomized controlled studies with large samples to cope with RLS.

Senso-immunology: crosstalk between nociceptive and immune systems.

Understanding the molecular mechanisms of nociception has recently grown impressively. Nociception is mediated by mechanical, chemical, or microbial stimuli that evoke unpleasant feelings, alerting the host of the risk of tissue damage. Such diverse arrays of noxious stimuli trigger various escape reactions, usually altering immune homeostasis. Notably, nociceptors can recognize cytokines or pathogens via sensory molecules or innate immune receptors, participating in immune responses. Accumulating evidence suggests that activated nociceptors produce various humoral factors that affect the immune system and act like endocrine/paracrine signals. Thus, understanding the interplay between the nociceptive and immune systems may open new avenues for the development of an interdisciplinary research field, hereinafter referred to as 'senso-immunology'. This review will discuss the physiological relevance of the senso-immune system in the host defense context, focusing on how senso-immune research might yield novel treatments to cure pain and inflammation.

Spatiotemporal frequency characteristics of the visual unpleasantness of dynamic bandpass noise

Recent psychophysical evidence shows that visual discomfort and unpleasantness are related to particular image features such as the spatial frequency and orientation spectrum. We also have a strong unpleasant feeling toward moving objects such as swarming worms, but it is poorly understood how motion information relates to a feeling of unpleasantness. The present study investigated spatiotemporal frequency characteristics that cause visual unpleasantness using bandpass noise with variable spatial frequencies, temporal frequencies, temporal frequency bandwidths, and orientation bandwidths. Results show that dynamic noise with relatively low temporal frequencies (0.5–2 Hz) was markedly more unpleasant than static noise, including that judged as the most unpleasant in a previous study. Remarkably, translational motion of the noise did not increase the feeling of unpleasantness. A subsequent experiment using a dynamic texture in which elements moved in a variable range of random directions showed that the variegated motion direction plays a critical role in promoting visual unpleasantness. Natural scenes have regularity in that features inside an object usually move in the same direction and rarely at random, and the present results further support the notion that deviation from the statistical regularity of natural scenes in images and movies induces negative emotions.

Self-produced audio-visual animation introduction alleviates preoperative anxiety in pediatric strabismus surgery: a randomized controlled study

BackgroundHospital anxiety caused by strabismus surgery has an unpleasant and disturbing feeling for both children and their parents. This study aimed to determine the effect of viewing a self-produced audio-visual animation introduction on preoperative anxiety and emergence agitation of pediatric patients undergoing strabismus surgery.MethodsIn this prospective randomized study, 1 hundred children scheduled for strabismus surgery with aged 3 ~ 6 years. The children were randomly divided into 2 groups (n = 50 for each), Group A: using a self-produced audio-visual animation introduction; Group C: controlled group without audio-visual animation introduction. Children’s preoperative anxiety was determined by the modified Yale Preoperative Anxiety Scale (mYPAS) at different time points: the night before surgery(T1), at pre-anesthetic holding room(T2), and just before anesthesia induction(T3). The Spielberger State-Trait Anxiety Inventory (STAI) was used to record the anxiety of parents at T1,T2 and T3. The incidence and the degree of emergence agitation were recorded.ResultsThe mYPAS scores at T2 and T3 were higher than T1(p < 0.05) in both groups. The average score of mYPAS in Group A was significantly lower than in Group C at T2 and T3(p < 0.05). The STAI scores in Group A at T2 and T3 were significantly lower than in Group C(p < 0.05). The incidence of agitation in Group A was lower than that in Group C(p < 0.05).ConclusionsBased on the findings, viewing a self-produced audio-visual animation can effectively alleviate the preoperative anxiety for both children and their parents in pediatric strabismus surgery, and it was effective for reducing emergence agitation as well.Trial registrationThe trial was prospectively registered before patient enrollment at Chinese Clinical Trial Registry (Clinical Trial Number: ChiCTR1900025116, Date: 08/12/2019).

The anxiety of nursing professionals during the COVID-19 pandemic period in a brazilian regional university hospital

IntroductionNursing work requires technical, scientific competence, knowledge, skill and emotional control over practice, considering that care presents risk situations, physical and emotional stress, responsibilities with people’s lives, coping with fears and suffering. All this situation in which the professional is exposed can lead to the occurrence of psychological wear, high stress and anxiety, this is conceptualized as a vague and unpleasant feeling of fear, apprehension, with characteristics of tension or discomfort derived from anticipating danger, something unknown or strange.ObjectivesTo identify the prevalence and factors associated with anxiety among nursing professionals who work coping with COVID-19 in a Brazilian regional university hospital.MethodsCross-sectional observational study, with sociodemographic questionnaire and anxiety measurement scale (HAD), with 88 nursing professionals. The data were analyzed using absolute and relative frequency, using the software StatisticalPackage for the Social Sciences.ResultsThere was a prevalence of anxiety (48.9%), with the majority of the sample consisting of women, over 40 years old, married or in a stable relationship, white, with higher education or postgraduate education, with income above R $ 3,000.00, tendered, with a work regime of 40 hours per week and time in the hospital from 1 to 5 years.ConclusionsThe impact should be considered on Nursing Mental Health caused by COVID-19 and intervene with coping strategies to minimize anxiety.

Momordica Charantia'nın Sıçan Ayak İltihabı ve Davranışı Üzerine Etkilerinin İncelenmesi; deneysel Model.

Background: Pain is one of the common experiences which is unpleasant feeling that originates from any part of the body, is associated with real or possible tissue damage and linked to human past experiences. Momordica Charantia (MC) or bitter melon mainly is used all around the world for the treatment of diabetes, cancer and inflammation- associated conditions due to the existence of many bioactive ingredients which have vigorous biologic effect. The aim of our study is to investigate how low and high doses of MC plant affect foot inflammation and animal's behavior.&#x0D; Materials and Methods: Sixteen male rats randomly divided into 4 experimental groups. Formaldehyde was (hind-paw formalin injection) administered for inducing pain model. After 24 hours MC (50 mg/kg, 200 mg/kg) was administered every day for five days. During the experiment, the pain thresholds, motor cortex measurements and inflamed foot volume, Locomotor Activity Test and Water Overflow Method in sequence.&#x0D; Results: According to our result, when we consider the foot volume, pain threshold and motor cortex data of our control group, there is no significant difference between the beginning and the last day, while On the 7th day, the pain threshold continues to decrease as the foot volume of our animals in our positive control group does not decrease. 200 mg concentration of MC has provided a great treatment by reducing the increasing foot volume at the same time pain threshold and motor activity was in highest level at 4th day.&#x0D; Conclusion: Our experiment shows that MC (200 mg/ml MC ) has high analgesic activity provides significant pain reduction and improvement in symptoms

Primum Non Nocere: Should Gene Therapy Be Used to Prevent Potentially Fatal Disease but Enable Potentially Destructive Behavior?

Aldehyde dehydrogenase 2 (ALDH2) deficiency constitutes one of the most common hereditary enzyme deficiencies, affecting 35% to 40% of East Asians and 8% of the world population. It causes the well-known Asian Alcohol Flush Syndrome, characterized by facial flushing, palpitation, tachycardia, nausea, and other unpleasant feelings when alcohol is consumed. It is also associated with a marked increase in the risk of a variety of serious disorders, including esophageal cancer and osteoporosis. Our recent studies with murine models have demonstrated that a one-time administration of an adeno-associated virus (AAV) gene transfer vector expressing the human ALDH2 coding sequence (AAVrh.10hALDH2) will correct the deficiency state and prevent alcohol-induced abnormalities of the esophagus and bone. If successful in humans, such strategy would reduce the increased risk-associated disorders such as esophageal cancer and osteoporosis, but also prevent the Asian Alcohol Flush Syndrome. This treatment thus raises ethical concerns: although it would potentially prevent fatal disease, it could also allow affected individuals to drink alcohol without suffering the Asian Alcohol Flush Syndrome and, hence, potentially enable personal destructive behavior. Here we explore the ethical arguments against the development of a gene therapy for ALDH2 deficiency and we find them wanting. We contend that development of such treatments is ethically appropriate and should be part and parcel of the solutions offered against the condition.

Washing hands and risk of cross-contamination during chicken preparation among domestic practitioners in five European countries

Nearly 40% foodborne outbreaks in the European Union are attributable to food practices in domestic homes that include handling and preparation of raw chicken. Hand washing is an important way to prevent cross-contamination with pathogens during chicken preparation. This study, which is part of the EU Horizon 2020 funded consortium SafeConsume, aimed at quantifying and understanding hand washing practices in three categories of households and five European countries. A quantitative survey (n = 1889) was combined with qualitative research, during which 75 participants from France, Norway, Portugal, Romania, and the United Kingdom were observed and interviewed. An original method for analysing video with “The Observer XT” software was developed to identify when and how risk arises. The quantitative survey and qualitative research data revealed that touching raw chicken was more frequent in Romania and Portugal. Practices to avoid touching raw chicken were declared and observed, although observations revealed that these practices were not always consistently followed. Only a third of the participants washed their hands with soap after handling raw chicken with important variations among countries (a majority in Norway and in the UK, a few in France and Portugal, none in Romania), in contrast to the results of the survey. Observations and interviews suggested that rinsing hands with water only and washing hands with soap are considered equivalent by many people. Barriers to washing hands due to improper equipment were mainly observed in Romania. Washing hands after touching raw chicken was motivated by food safety concerns for some participants in Norway and the UK, but not in France and Portugal, where it was motivated by unpleasant feelings on hands, or presented as a habit. Participants not washing their hands after touching the chicken did it after other actions they presumably perceived as unsafe (e.g. touching the bin, handling pets, and blowing the nose), indicating that they did not specifically consider touching raw chicken as risky. Knowledge, habits, and equipment with regard to chicken and hand washing differed among European countries, resulting in safe and risky practices.

Nurses’ use of non-pharmacological pain management methods in intensive care units: A descriptive cross-sectional study

BackgroundPain is a common and unpleasant feeling among patients in intensive care units. Therefore, the use of proper pain management methods, such as non-pharmacological interventions, is a priority in intensive care units. ObjectiveThis study aimed to ascertain the extent of the use of non-pharmacological pain management methods by intensive care unit nurses in Iran and to identify the obstacles that hindered the use of these methods. Material and MethodsThis study used a descriptive cross-sectional design which involved a convenience sample of 224 nurses who worked in 16 intensive care units across northern Iran. Data were collected using the non-pharmacological pain management questionnaire and a researcher-developed checklist of the obstacles that hindered the use of non-pharmacological pain management methods. ResultsA moderate number of ICU nurses used non-pharmacological pain management methods (55.8 %). The most common method used by nurses was repositioning (M = 2.72), while methods such as acupuncture and reflexology were used less frequently. Furthermore, the most common obstacles to the use of non-pharmacological pain management methods were nurses’ fatigue (M = 2.92) and multiple responsibilities (M = 2.91). Demographic variables such as age, gender, educational level, and work experience were not significantly associated with the use of non-pharmacological pain management methods. ConclusionsDue to factors such as fatigue, multiple responsibilities, a heavy workload, and an insufficient number of nurses per shift, the rate of utilization of non-pharmacological pain management methods among intensive care unit nurses in Iran was low. Furthermore, most of the participants in this study had not attended courses on non-pharmacological pain management.

Perception of discomfort by mechanical ventilation patients in the Intensive Care Unit: A qualitative study

BackgroundRoutine care in intensive care units (ICU) results in patient pain and discomfort. While pain is treated with analgesics, discomfort is generally not well characterised or addressed. Since many ICU patients communicate only non-verbally, practitioners often cannot discern between pain or discomfort when treating such patients, potentially leading to inappropriate analgesic administration. A first step in discriminating between pain and discomfort is understanding how patients perceive their discomfort. ObjectiveTo describe mechanically ventilated ICU patients’ perceptions of discomfort and how they differentiate discomfort from pain. MethodA qualitative descriptive study using semi-structured interviews conducted with 13 patients in a Medical and General ICU who survived mechanical ventilation. Transcripts were analysed using content analysis. FindingsTwo main discomfort themes were identified: unpleasant physical sensations and unpleasant psychological feelings. Each theme was further divided into subcategories. Most patients did not describe high levels of pain and did not associate physical discomfort with pain. ConclusionsDiscomfort, as described by patients, stems from both physical sensations and psychological feelings. Pain was less often described as a negative ICU experience, while other non-pain sources of discomfort were more likely to be recalled. Therefore, practitioners should not only focus on treating pain but also on treating overall comfort to improve the quality of the ICU experience and potentially decrease post-ICU psychological sequela.