Universal Remedy Research Articles

Spironolactone in modern cardiology: from many years of experience to the latest evidence of effectiveness (literature review)

Spironolactone is a drug that plays an important role in the treatment of various diseases, especially in the field of cardiology and endocrinology. First synthesized in 1957, spironolactone gained widespread recognition due to its unique ability to block the action of aldosterone, a hormone that plays an important role in the pathogenesis of many cardiovascular diseases and increases the risk of severe cardiovascular complications. Spironolactone is included in the list of essential medicines of the World Health Organization. In cardiology, it is one of the universal remedies, because it is prescribed for resistant or secondary hypertension, heart failure, as part of hormonal therapy and in a number of other clinical conditions and situations. Resistant hypertension is a complex and serious medical problem, which is a significant challenge for doctors and patients, as it requires a specialized and individualized approach to treatment. Clinical studies found that spironolactone was the most effective adjunctive drug for the management of resistant hypertension, and this superiority of spironolactone confirmed the central role of sodium retention in the development of treatment resistance. Studies have shown that the addition of spironolactone to initial combination therapy resulted in a more potent antihypertensive effect compared to the addition of doxazosin or bisoprolol. The proportion of patients in whom spironolactone was the optimal blood pressure-lowering drug appeared to be the largest, according to the analysis on the prediction of the effect of each drug on the blood pressure level using plasma renin and the probability that different drugs will be best at different points of renin distribution in the blood plasma. Spironolactone has been used in modern cardiology for a long time to treat patients with heart failure and atrial fibrillation, but in this article, we have focused on another very important site for spironolactone administration, namely hypertension, especially in its resistant forms.

Eco-friendly products and gender: an exploration of environmental perspectives

Countries must balance growth in economy with ecological preservation in order to successfully address the degradation of the environment. This frequently entails putting in place laws and procedures that support eco-friendly technologies, conserve natural resources, and promote ethical consumer behavior. There do not exist universal remedies because different countries and areas face different issues and have different opportunities. The principal objective of this study is to evaluate gender differences in perceptions of the environment and eco-friendly products. Moreover, this research evaluate the connection between environmental consciousness and eco-friendly products. According to the t test results, there are no noticeable gender disparities in people's perspectives toward the environment and eco-friendly products. The underlying variables of environmental perspectives have been separated into primary factors by the rotational factor matrix. According to the outcomes of the multiple regression assessment, customer perceptions of the function of the authorities and their individual requirements for environmental behavior had a substantial impact on how they felt about eco-friendly products. Further research found that the most significant factor influencing people's perceptions toward eco-friendly products was personal norm. On the other hand, the public's perceptions toward eco-friendly products were not significantly influenced by the preservation of the environment.

The Art of the (Im)possible: Ethical Limits and Christian “Kenotic” Inspirations for Diplomacy

The aim of this article is to challenge an ideologically overestimated view of diplomacy as a universal self-sustaining value and remedy for unpredictably chained and escalated conflicts in the world. The article shows the necessary connection between diplomacy and the fragility of human ethical decision-making, including in the areas of strategy, international politics, and military defense. This more modest approach also applies to proposals for diplomacy built on direct or indirect religious inspirations. The article calls for a nuanced critical approach to religious diplomacy and the positive transformation of the limits of human rational negotiation by the paradoxical “power of the powerless” and transcendental mystery. The final part provides three biblically-inspired Christian opportunities for this transformation: endurance of faith, voluntary self-denial (kenosis), and the complex “two level”—both protective and eschatological—pursuit of peace.

Этнические партии в политических системах мультиэтничных государств

The article provides a comparative study of the place and role of “ethnic parties” in the modern world, in which ethnicity is extremely politicized, which often contributes to the emergence of interethnic conflicts and destabilization of the political systems of multiethnic states. The author analyzed six really practical ways of including ethnic parties in the political process: (1) ethnic parties representing minorities living compactly in a region advocate changing the status quo – an institutional transformation of center–regions interactions associated with an increase in the status and subjectivity of such a region/minority; (2) a regional ethnic minority, through an ethnic party, fights for the preservation of the status quo if there is a threat to the already existing status of the group or it has been lost for some reason; (3) the use of ethnic parties as a factor of influence from the outside, which is fraught with increased tension in the relations of two or more neighboring states; (4) situations when activities of ethnic parties contribute to the split, degradation and even destruction of political systems; (5) a situation when an ethnic/regional party seeks greater territorial autonomy or even the (re-)creation of “its own national state”; (6) activities of ethnic parties in the conditions of so-called “ethnic democracies”. Further, the institutional conditions for ensuring the political representation of ethnic minorities, while maintaining the stability of the political system, are investigated. As a result, the author comes to the conclusion: despite the fact that the ethnization of the political process potentially divides and even opposes people of different ethnicities and thereby can strengthen the split in society, the inclusion of ethnic parties in the developing of a national political course allows reducing interethnic tensions, and ethnic minority groups receive a channel for broadcasting their own needs and attitudes both to the state power and to non-ethnic citizens of the country. Therefore, the ban on the creation of ethnic and regional parties cannot be considered as a universal anti-crisis remedy and even more so as a panacea for all political ills.

The Truth of Erasure: Universal Remedies for Universal Agency Actions

The Truth of Erasure: Universal Remedies for Universal Agency Actions

The reproductive system of breast organs in cows and evaluation the function using a mineral adaptogen

Infertility problems still remain an urgent task of practical veterinary medicine. There are many drugs known to have an effect on the organs of the reproductive system, but the search for universal remedies is a priority. The effectiveness of drugs that prevent infertility can be assessed by reducing infertility days and reducing the cost of purchasing sperm products. Restoration, enhancement and prolongation of lactation also ensures the effectiveness of dairy cattle breeding. Therefore, the search for effective means of prevention and treatment is the purpose of this study. The article describes the results of research on the effect of mineral adaptogen on the function of the reproductive system and breast organs in cows. The article presents the results of changes in hematological and biochemical blood tests in cows receiving adaptogen during the dry period and the state of the reproductive system, breast and milk productivity, against the background of taking adaptogen. As a result of the conducted research, a decrease in the incidence of reproductive organs and udders was noted. Reduction of complications in childbirth and the postpartum period. A decrease in the incidence of neonatal pathology in newborn calves was noted. In addition, an increase in dairy productivity.

Aligners, can my child use them too?

This is a frequently asked question. The answer depends on various factors, with cooperation being among the most essential. As a parent, you must ask yourself if you can rely on your child to wear aligners correctly for most of the day. If the answer to this question is yes, then clear aligners may be a better choice than traditional braces. There are three major benefits of clear aligners in children: 1. Greater comfort, aligners are less voluminous than traditional braces and more likely to prevent irritation, mouth ulcers and other discomfort that derives from the movement of the orthodontic wire or braces. 2. Better hygiene, as their removal during meals and tooth cleaning manoeuvres makes home oral hygiene easier. 3. Better aesthetics, thanks to the transparency of the plastic replacing the metal. However, a certain degree of caution is advised to those who are considering this treatment option. Although aligners allow us to start resolving certain tooth malpositions (which can cause periodontal and aesthetic problems or increase the severity of damage in the event of trauma), and to improve alignment and minor crowding at an early age, it must not be forgotten that the intervening period for changing the definitive position of individual teeth is still the period of permanent teeth. It is important to consider whether a child has a dental or skeletal problem. In cases where a child's problem is exclusively dental, the aligner may be one of the tools used. In cases of skeletal problems, the literature advises against the aligner, as it is not the right instrument at this stage of development. The literature in some cases refers to aligners as the universal remedy, valid for every malocclusion, presenting them as a panacea for all orthodontic problems of very young patients. It is necessary to remain open to the innovations that the market offers us and that can improve our daily clinic, and aligners can be a valid support in this regard, but, as dentists, we should always keep a critical and open eye on treatments with an evidence-based rationale. As with all other orthodontic appliances, aligners must be evaluated on a case-by-case basis, keeping in mind that they are one of the tools in the hands of the clinician. When the clinical situation makes it possible and when both the child's requirements and the parent's expectations are fulfilled, it is certainly worth considering clear aligners as a viable route in the family-child's orthodontic treatment, making it as simple and convenient as possible. Lastly, we should remember the concept of efficiency regarding an orthodontic treatment, which depends on its cost/benefit ratio, with the former being understood in a biological sense and in terms of its impact on the life of the patient and their family with respect to duration, cooperation required, discomfort induced by the equipment used and frequency of check-ups. The latter should obviously be considered in terms of results obtained in relation to the pre-established treatment goals. A consideration that we should always keep in mind: let us never forget that is the orthodontist who treats the patient, not the appliance!

Whatever the problem, entrepreneurship is the solution! Confronting the panacea myth of entrepreneurship with structural injustice

A topic of growing interest in entrepreneurship research is how entrepreneurial ventures address grand challenges. This literature, we argue, tends to produce a panacea myth by suggesting that entrepreneurship is the universal remedy for existing social and environmental ills. Starting from the claim that the persuasive power or ‘stickiness’ of the panacea myth depends not only on what it explicitly says (in terms of ideas and beliefs) but also on what it leaves out, we suggest that the exclusion of explicitly political and holistic explanations of grand challenges such as Iris Marion Young's theory of structural injustice, which we use as an illustrative example, precipitates a ‘constitutive absence’ whose mythic function is to sanitize the image of entrepreneurship as the preferred solution to grand challenges. In an effort to denaturalize the panacea myth, we first identify three ‘figures of thought’ – coined ‘extrapolation fallacy,’ ‘political agnosticism,’ and ‘positive acculturation’ – that define the content of the panacea myth while simultaneously excluding theoretical concepts and frameworks, such as structural injustice, that conceptualize grand challenges as structural, multidetermined, and inherently political problems that are not necessarily amenable to stand-alone entrepreneurial approaches and solutions. Second, to loosen the grip of the panacea myth, we suggest rethinking entrepreneurship research in terms of who is involved, what methods are used, and how we talk about it. Taken together, these tactics create an opening in entrepreneurship research for a more complexity-sensitive and political understanding of grand challenges that cultivates a more humble and realistic depiction of entrepreneurship's problem-solving capacity.

A systematic review of the pharmacological effects of the active ingredients of blood-red hawthorn in cardiovascular diseases

Cardiovascular disease is widespread at the present time, causing the disability of the population. The main risk factors are hyperlipoproteinemia, hypertension, hyperglycemia, etc. Blood-red hawthorn Crataegus sanguinea, a species of the genus Hawthorn (Crataegus) of the Rose family (Rosaceae) is a universal remedy for the prevention of diseases of the cardiovascular system. Hawthorn medications have antihypertensive, cardioprotective, cardiotonic, antiarrhythmic, mild diuretic, antispasmodic and sedative effects. At the same time, biologically active substances of hawthorn are non-toxic and do not have pronounced side effects with prolonged use. In this regard, it is important to study the mechanisms of pharmacological action of drugs based on this plant in order to prolong and improve the quality of life of the population.

Vipassana Meditation an Indigenous Approach for Good Self-Esteem and Self-Efficacy

Vipassana is one of the most ancient techniques of mindful meditation found and practiced in India. History of vipassana can be traced back to 2500 years ago, when Gautama Buddha rediscovered this ancient Indian practice. Buddha taught vipassana as a universal remedy for all illness. Vipassana is self-transformation technique through self-observation that brings deep awareness about mind and body interconnection. The present study aimed to compare the level of self-esteem and self-efficacy of adults who practice vipassana and also those who do not practice vipassana. The research was conducted on 32 number of adults, among them 16 adults practiced vipassana and the rest 16 did not have awareness about the practice. Questionnaire survey and interview method was utilized in the collection of data. Generalized Self-Efficacy Scale (GSES) and Rosenberg self-esteem scale was used in the research. To analyse the data mean, SD and t-test was used. The research emphasized the relevance of vipassana in today's modern world for better mental health.

Anesthesia and the Classics: Essays on Avatars of Professional Values

Anesthesia and the Classics: Essays on Avatars of Professional Values

'Garlic-lipo'4Plants: Liposome-Encapsulated Garlic Extract Stimulates ABA Pathway and PR Genes in Wheat (Triticum aestivum).

Recently, environmentally friendly crop improvements using next-generation plant biostimulants (PBs) come to the forefront in agriculture, regardless of whether they are used by scientists, farmers, or industries. Various organic and inorganic solutions have been investigated by researchers and producers, focusing on tolerance to abiotic and biotic stresses, crop quality, or nutritional deficiency. Garlic has been considered a universal remedy ever since antiquity. A supercritical carbon dioxide garlic extract encapsulated in nanoscale liposomes composed of plant-derived lipids was examined as a possible PB agent. The present study focused on the characterization of the genes associated with the pathways involved in defense response triggered by the liposome nanoparticles that were loaded with supercritical garlic extracts. This material was applied to Triticum aestivum in greenhouse experiments using foliar spraying. The effects were examined in a large-scale genome-wide transcriptional profiling experiment by collecting the samples four times (0 min, used as a control, and 15 min, 24 h, and 48 h after spraying). Based on a time-course expression analysis, the dynamics of the cellular response were determined by examining differentially expressed genes and applying a cluster analysis. The results suggested an enhanced expression of abscisic acid (ABA) pathway and pathogenesis-related (PR) genes, of which positive regulation was found for the AP2-, C2H2-, HD-ZIP-, and MYB-related transcription factor families.

Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis

Conflicting results on melatonin synthesis in multiple sclerosis (MS) have been reported due to variabilities in patient lifestyles, which are not considered when supplementing melatonin. Since melatonin acts through its receptors, we identified melatonin receptors in oligodendrocytes (OLs) in the corpus callosum, where demyelination occurs; the subventricular zone, where neural stem/progenitor cells (NSPCs) are located; and the choroid plexus, which functions as a blood-cerebrospinal fluid barrier. Moreover, using chimeric mice, resident macrophages were found to express melatonin receptors, whereas bone marrow-derived macrophages lost this expression in the demyelinated brain. Next, we showed that cuprizone-fed mice, which is an MS model, tended to have increased melatonin levels. While we used different approaches to alter the circadian rhythm of melatonin and cortisol, only the constant light approach increased NSPC proliferation and differentiation to oligodendrocyte precursor cells (OPCs), OPCs maturation to OLs and recruitment to the site of demyelination, the number of patrolling monocytes, and phagocytosis. In contrast, constant darkness and exogenous melatonin exacerbated these events and amplified monocyte infiltration. Therefore, melatonin should not be considered a universal remedy, as is currently claimed. Our data emphasize the importance of monitoring melatonin/cortisol oscillations in each MS patient by considering diet and lifestyle to avoid melatonin overdose.

El rediseño del Palacio del Presidente en Kazajistán

Introduction: This paper deals with the renovation process of the President’s Palace in Kazakhstan. Diversity is one of our main features expressing the nationwide experience along with its successes and failures. The spatial quality of some public spaces provided them permanence and "sustainability". The aesthetic values of architectural and urban spaces are often determinant factors for urban environmental quality. In fact, our research strategy combines the study of spatial practice and usage with the analysis of design quality. The rejuvenation of urban spaces is a promising experience contributing socially, economically, and physically to regenerating the local urban environment and leisure activity. Sustainable urban development provides city designers with criteria of social and ecological rationality that are different from those available in the market. Consequently, the concept of sustainability becomes the keystone of the urban development process. Materials and Methods: This paper puts forward a question about the global features of a public park and continues the discussion on keeping a balance between local architecture and the global ‘public park making’ trend the method employed is qualitative interviews, observations, and walking tours with public space users. An amount of data is collected for environmental assessment. Results and Discussion: The renovated park shows the new way public space is oriented. In President's Palace, a new logic of urban publicity was assembled and built into the landscape. we analyzed the social and technical means. New public spaces of this sort promulgate a conception of the public that not only combine with discourses of democratization, citizenship, and self–development and is connected ever more firmly to consumption and commercial. Conclusions: We also do research on the global features of a public park and discuss keeping a balance between local architecture and the global public park-making trend, as well as public facilities and profit, and the role of nature as a universal remedy and tool in reshaping the image of cities.

Social connectedness and cognitive decline

Social connectedness and cognitive decline

Managing Affective Commitment to Change in Public Sector Organization of Pakistan: A Social Exchange Perspective

Literature on organizational development is well-stocked with researches advocating change as a universal remedy for organizational survival and success. However, the importance of eliciting positive employees’ response during change lacks attention. Considering the crucial role of managing employees’ positive change reactions in public sector organizations, the current study highlights the role of High Performance Work Systems (HPWS) in fostering affective commitment to change (ACTC) in culturally diverse employees’ along with its interlinking mechanisms. Based on Social Exchange perspective, we hypothesized that employees’ perceptions of the nature of exchange mediates the relationship between HPWS-Affective commitment to change. More specifically, we proposed a moderating mediation model outlining how individual’s cultural orientation might play a significant role in influencing the nature of exchange which in turn may predict the dynamics of HPWS-employees’ affective commitment to change relationship. A sample of 591 full-time employees from the largest public-sector bank of Pakistan undergoing Privatization were surveyed. The results reveal the positive impact of High performance work systems on affective commitment to change. Moreover, employees’ perceptions of social exchange mediate the positive relationship between HPWS and Affective CTC. However, this underpinning mechanism is stronger for employees scoring high collectivism and low power distance orientation and vice versa. The study contributes to the literature through examining the intermediatory mechanism and boundary conditions under which the positive impact of HPWS- Affective CTC might prove to be more effective. Finally, both practical and theoretical implications are discussed in the light of results obtained followed by future directions.

An Ode to Curcumin: One Hundred Mechanisms of Curcumin’s Effectiveness Against Human Pathological Conditions

Currently, a large amount of experimental data has been accumulated, which confirm that the main component of turmeric, curcumin, has a high biological activity and a wide spectrum of action. Curcumin is used in the practice of clinical medicine as an effective anti-inflammatory, antioxidant, neuroprotective, detoxifying and antiseptic agent. Based on numerous reviews of clinical studies, it seems possible to use this biologically active substance in therapy as a universal remedy for the prevention of the development and complex treatment of many pathological conditions.

On the Optimization of Nitrogen‐Reduction Electrocatalysts: Breaking Scaling Relation or Catalytic Resonance Theory?

AbstractElectrochemical nitrogen reduction reaction (NRR) is mainly hampered by two facts. On the one hand, the hydrogen evolution reaction competes with the NRR under cathodic reaction conditions. On the other hand, the sluggish reaction kinetics of the NRR, due to the transfer of six proton‐electron pairs in the reaction mechanism, causes large overpotentials, and thus results in humble intrinsic activity for ammonia formation. Optimization strategies for NRR electrocatalysts are ultimately called for to overcome these issues. While breaking scaling relation is considered as a universal remedy to enhance turnover for any electrocatalytic process, recently, the concept of catalytic resonance theory has been put forth as a second option to obtain reaction rates beyond the limiting Sabatier volcano. Yet, a comparison of these two concepts is missing but urgently needed to comprehend design principles for electrocatalyst optimization on the atomic scale. In the present work, breaking scaling relation and catalytic resonance by programmable catalysis are compared on the example of the NRR over transition‐metal oxides. It is demonstrated that a fine tuning rather than a full breaking of nitrogen‐containing scaling relations is required to enhance electrocatalytic activity of electrocatalysts at the volcano apex. The success of catalytic resonance theory is based on the occurrence of negative scaling correlations whereas in the case of positive scaling correlations, the impact of this approach on the optimization of electrocatalysts strongly depends on the location of the material in the volcano plot. The obtained insight may spur the development of NRR electrocatalysts with enhanced intrinsic activity by following the outlined design principles.

The role of myofibroblasts in the healing of chronic wounds

Surgical infection is one of the most important and important problems of modern medicine. The lack of a universal remedy and method of wound treatment, the difficulty of choosing universal tactics of management of patients with chronic wounds determines the need for further search for new treatments that stimulate reparative processes in chronic wounds, including morphological research methods. The role of cellular regulation in the pathogenesis of the restoration of the morphofunctional state of a chronic wound in the conditions of its damage remains undisclosed. Therefore, the aim of our study was to evaluate the role of myofibroblasts in the healing of chronic purulent-necrotic wounds in the treatment of mesenchymal stem cells using immunohistochemistry. In the experiment we obtained a model of chronic purulent-necrotic wound, which meets all the requirements for quality indicators in the study of morphological changes in chronic wounds and can then be used as a basis for preclinical research. The condition of chronic purulent-necrotic wounds in 120 rats was studied by histological and immunohistochemical methods. Chronic wound was modeled according to the original method of the author: during the formation of a standard skin defect in the interscapular area of the rat with a diameter of 1 cm, the surrounding tissue was superimposed ischemic metal structure to reduce blood flow in the wound area, which significantly slowed the delay. Treatment was started from 28 days from the beginning of wounding, which clinically and histologically corresponded to the chronicity of the wound process. Statistical processing of morphometric parameters was performed using the standard software package “Statistica 6.1”. It was found that the positive dynamics of healing of chronic wounds, using 0.025 % decasan solution, was observed mainly in the early stages (3-7 days), while mesenchymal stem cells (MSC) and MSC cloned in inert gases (MSC-IG) were effective at all stages of the study. The use of MSC and MSC-IG creates favorable conditions for the normal course of regenerative processes and epithelialization of wounds, providing anti-edema and anti-inflammatory effects with activation of myofibroblasts, which increases the healing efficiency of chronic purulent-necrotic wounds. Prospects for the use of MSC in the treatment of chronic wounds are shown.

Statistical analysis of breaking scaling relation in the oxygen evolution reaction

The application of proton exchange membrane electrolyzers in practice to produce gaseous hydrogen as energy vector is majorly hampered by the sluggish oxygen evolution reaction (OER) at the anode. On the atomic scale, a scaling relation between the OH and OOH intermediates has been recognized as main limitation for the development of highly active OER catalysts. Breaking scaling relation is considered as a universal remedy to obtain OER materials with enhanced electrocatalytic activity. While it is a well-accepted paradigm that the optimum OER catalyst reveals a symmetric thermodynamic free-energy landscape, recently, it was suggested that the thermodynamic ideal may correspond to a free-energy landscape with asymmetric shape, allowing thermoneutral stabilization of the key intermediate at the target overpotential. In the present manuscript, we analyze breaking scaling relation in the OER to the symmetric and asymmetric thermodynamic free-energy landscapes by statistical methods at different applied overpotentials. Our analysis reveals that breaking scaling relation to the asymmetric rather than to the symmetric picture is statistically more significant as soon as an overpotential is applied, calling for a change in mindset when thermodynamic considerations are used for catalyst optimization.