Universal Remedy Research Articles

Gold complexes and their effect on antiarthritic activity and anticancer activity

Gold was considered as universal remedies for diseases like inflammation, infections, etc in 19th century. Later in 20th century Robert Koch discovered Gold complex Potassiumdicyanidoaurate(I) showing activity against Mycobacterium tuberculosis , later the treatment was proved to be ineffective subsequently. Further in 1985 Auranofin (Gold salt) was introduced for the treatment of Rheumatoid Arthritis, which had to be taken orally and believed to be the major discovery till injectable gold came into existence. The function of drugs based on gold is majorly related to Rheumatoid arthritis but engrossment has bent towards the adequacy of Gold compounds for anti cancer activities. The review article summarizes the current research on Gold complexes and their biological activities against cancer as well as in case of RA.

Principles of Monetary & Financial Sustainability and Wellbeing in a Post-COVID-19 World: The Crisis and Its Management

This paper analyses the COVID-19 crisis and its management from the perspective of Austrian Economics. The attention focuses on the State’s coercive intervention according to the principles of political economy, capital theory and Austrian business economic cycles. The paper examines the specific case of massive intervention by governments and, especially, central banks in monetary and financial markets to deal with the pandemic trying to mitigate its negative effects. The paper offers a critical analysis of government tax policies and the increase in public spending, considered as the panacea and universal remedy for the social troubles. This review concludes with a proposal to change the mainstream paradigm, thereby proposing a more sustainable and wellbeing economics.

Agile Approach as a Universal Remedy for the Usual Failure in the Development of Software Projects

Background: Agile is not a methodology neither can it be considered as a peculiar way of developing any software also it is neither a framework nor a process. Agile is a mindset or a collection of beliefs that can be used by the teams for taking the decisions while working on any software development. Agile mindset adopted for the development of software has gained attention of the researchers and industries across the world because otherwise the software project would turn out to be uncertain and very turbid. The universal remedy for the usual failure of the software project development is the agility. Actually saying agile is nothing novice instead it is a meta model based on best practices from the preceding models like waterfall, iterative, incremental and rapid application development method. Objective: The objective of this paper is to highlight various points of comparison between them and conclude that failing fast is failing cheap in case of agile for software development. Methods: So, we can say that an agile always existed but not in a structured and a formal manner. The two main methodologies of agile as an umbrella term are XP and scrum. Results: Thus in this paper we have discussed about scrum as a major methodology and also how various scrum roles contribute towards making teams self-organized to reduce the usual rate of failure of development projects. Conclusion: The success rate of the software applications developed through the agile concept is three times than that of the traditional waterfall method and also the percentage of cost and time overruns is much lower.

The Effect of Anthropomorphism and Failure Comprehensibility on Human-Robot Trust

The application of anthropomorphic features to robots is generally considered to be beneficial for human- robot interaction. Although previous research has mainly focused on social robots, the phenomenon gains increasing attention in industrial human-robot interaction, as well. In this study, the impact of anthropomorphic design of a collaborative industrial robot on the dynamics of trust is examined. Participants interacted with a robot, which was either anthropomorphically or technically designed and experienced either a comprehensible or an incomprehensible fault of the robot. Unexpectedly, the robot was perceived as less reliable in the anthropomorphic condition. Additionally, trust increased after faultless experience and decreased after failure experience independently of the type of error. Even though the manipulation of the design did not result in a different perception of the robot’s anthropomorphism, it still influenced the formation of trust. The results emphasize that anthropomorphism is no universal remedy to increase trust, but highly context dependent.

Systemic treatment of psoriasis: from methotrexate to biologics

Psoriasis is one of the most frequent chronic inflammatory skin diseases and it has been of interest to many scientists for ages. The review presents data on all systemic treatment options, that are to date officially registered in Russian Federation for moderate-to-severe psoriasis. Aspects of the mechanism of action, efficacy and tolerability of both basic drugs (methotrexate, cyclosporine, acitretin) and biologics (infliximab, adalimumab, etanercept, certolizumab pegol, ustekinumab, guselkumab, secukinumab, ixekizumab, netakimab) and small molecules (tofacitinib, apremilast) are considered in detail. Special emphasis is placed on the important nuances of biological therapy: immunogenicity, drugs' survival and switch due to lack of efficacy. Invention of biologics signified a new era of moderate-to-severe psoriasis treatment. It became possible to achieve complete clinical remission more safely, which significantly improved the quality of life of patients. However, due to the unknown etiology of psoriasis, there is still no universal remedy that would allow to cure every patient, this fact makes scientists from all over the world keep conducting numerous clinical trials to find even more effective and safe therapeutic options.

THEORETICAL ASPECTS OF CRIME PREVENTION

The problem of criminality prevention is being updated. The relevance of issues related to crime prevention as the main factor of criminality prevention in general is substantiated. The essence of criminality prevention is in implementation of the law's educational function. Its mission is not in punishment, but in fostering anti-criminal cogitative-behavioral “in-stincts” of a personality. Criminality prevention should be based on certain universally rec-ognized international and national principles aimed at decriminalizing the identity of poten-tial criminals. Crime theory is a whole system of modern scientific knowledge, forms and methods (historical, socio-political, psychological, medical, legal, economic, etc.). The urgency of the research is caused by the fact that in the conditions of the Russian re-ality criminality is the most serious form of a social disease, in the “treatment” of which there are no universal and final remedies. There are only means to stabilize it, to minimize, to reduce it, etc. It is really utopian to remain on its complete eradication by state-legal means. However, the latter is very relevant for society, the state, the citizen. The problem of criminality prevention is notable for its complex and multifaceted character. Therefore, the state has applied and is now applying all available civilized means of its social and legal control. Effective criminality prevention requires improved law en-forcement activities, namely, focusing on identifying, researching, analyzing the main as-pects of criminality prevention, as well as on characterization and evaluation of the crim-inality prevention system in modern conditions, taking into account domestic and foreign experience. Various methods for prevention of crimes and offenses are analyzed. Criminality preven-tion must be understood as a specific direction in the state activity to affect the causal set of illegal behavior and conditions conducive to it, which results in the reduction, stabilization, quantitative reduction and qualitative mitigation of crime.

Anti-Idiotypic Agonistic Antibodies: Candidates for the Role of Universal Remedy.

Anti-idiotypic antibodies (anti-IDs) were discovered at the very beginning of the 20th century and have attracted attention of researchers for many years. Nowadays, there are five known types of anti-IDs: α, β, γ, ε, and δ. Due to the ability of internal-image anti-IDs to compete with an antigen for binding to antibody and to alter the biologic activity of an antigen, anti-IDs have become a target in the search for new treatments of autoimmune illnesses, cancer, and some other diseases. In this review, we summarize the data about anti-IDs that mimic the structural and functional properties of some bioregulators (autacoids, neurotransmitters, hormones, xenobiotics, and drugs) and evaluate their possible medical applications. The immune system is potentially able to reproduce or at least alter the effects of any biologically active endogenous or exogenous immunogenic agent via the anti-idiotypic principle, and probably regulates a broad spectrum of cell functions in the body, being a kind of universal remedy or immunacea, by analogy to the legendary ancient goddess of universal healing Panacea (Πανάκεια, Panakeia in Greek) in the treatment and prevention of diseases, possibly including non-infectious somatic and even hereditary ones.

Section 706 of the Administrative Procedure Act Does Not Call for Universal Injunctions or Other Universal Remedies

Section 706 of title 5 instructs courts reviewing agency action to hold unlawful and set actions that fail the tests it sets out. Trump v. Pennsylvania, currently before the Supreme Court, raises the question whether Section 706 directs the courts to give so-called universal remedies: remedies that apply to all persons subject to a challenged agency action, not just the plaintiff. Section 706 does not call for universal remedies, including the universal injunction the Third Circuit approved in Trump v. Pennsylvania, because it does not address remedies at all. Section 706 instructs courts to set unlawful agency action aside in the sense of not deciding according to it. Whether the reviewing court should issue an order that vacates the agency's decision, the way an appellate court can vacate a lower court's judgment, depends on the form of proceeding for judicial review being used in the case. In many forms of proceeding for judicial review, such as enforcement proceedings with the private party as the defendant, the court has no occasion to issue any such order. This conclusion about section 706 emerges from the text and structure of the APA. Section 706 applies in all the proceedings for judicial review contemplated by section 703. It therefore must be capable of application in all those proceedings. Section 703 contemplates several kinds of lawsuit in which the reviewing court is not in the position of an appellate tribunal that can vacate the decision below. To be general enough to apply in all those proceedings, section 706 must mean that the reviewing court is to set unlawful agency action aside by not following it. In an injunctive proceeding like Trump v. Pennsylvania, not following the agency's regulation entails giving an injunction against its enforcement. It does not entail vacating the agency action in any other sense. Because section 706 does not call for any remedy, it does not call for a universal remedy.

Modern Vasopressor Therapy of Septic Shock (Review)

Septic shock, as the most severe form of sepsis, is characterized by high mortality reaching 40% despite the use of the most modern standards of diagnosis and treatment. In the thanatogenesis of septic shock, vasoplegia plays a leading role, respectively, and therapy of the condition under discussion involves the use of vasoconstrictors, along with the standard prescription of infusion therapy, antibiotics and symptomatic treatment. The choice of a specific vasoactive drug is a difficult task for a practicing anesthetist, as along with undoubtedly positive properties, vasoconstrictors each have their own spectrum of undesirable side effects, which, of course, must be taken into account when determining treatment tactics.The aim of review:A comprehensive assessment of the multifactorial effect of various vasoconstrictors on the patient to determine the criteria for choosing the optimal drug (or a combination of drugs) in septic shock.The search was carried out using PubMed and Scopus databases, the final selection of 89 articles was carried out in accordance with the following criteria: relevance to the topic of this review and the nature of the article — only randomized controlled trials, guidelines and analytical reviews were included in the final analysis.External and internal mechanisms of vascular tone regulation are considered, including factors produced by endothelium (nitric oxide, prostacyclin, endothelin); vasoactive metabolites and autocoids — signal molecules of local action (serotonin, prostaglandins, thromboxane A2). Accordingly, drugs were analyzed the mechanism of action of which is related to the effect on adrenergic (adrenaline, dopamine, norepinephrine, phenylephrine, dobutamine), vasopressin (vasopressin, terlipressin, selepressin) receptors, synthetic analogues of angiotensin (angiotensin II) and drugs the non-vasopressor effect of which is not linked with the receptor apparatus (methylene blue, levosimendan, hydrocortisone).Conclusion.The high effectiveness of norepinephrine, its positive hemodynamic effects make the drug under discussion, in many ways, a universal remedy for the relief of septic shock. However, refractory shock may require the introduction of such high doses of norepinephrine that the occurrence of adverse reactions will become practically inevitable. The combined use of adrenergic and ligand V receptors, terlipressin, is intended to prevent these complications. However, to date, there are no clear recommendations on the use of terlipressin in septic shock, which limits its use in clinical practice.

Universal Remedies, Section 706, and the APA

Universal Remedies, Section 706, and the APA

Kandidatenaufstellung zur Bundestagswahl 2017. Untersuchungen zu personellen und partizipatorischen Grundlagen demokratischer Ordnung

The political parties represented in the Bundestag have about 300 .000 active members, from whom all elected officials, from local councils to the European Parliament, are recruited . Due to the ongoing membership decline in parties the pool of eligible candidates is also reduced . In spite of this worrying development and the outstanding importance of the parties’ recruitment function for the stability and functioning of the political system, for the last five decades the candidate selection processes for the German Bundestag have neither been analyzed extensively nor systematically . Hence, the Institute of Parliamentary Research (IParl) addressed this research gap and studied the candidate selection before the German parliamentary elections of 2017 by asking who selects whom in which way and for what reasons in the constituency or for the party lists as candidate for the German Bundestag . The results underline the worrying situation: Not only the personal but also the participatory basis of democracy has been shrinking over time . Although the parties hold membership conventions more often, in 15 years the participation of the electorate from CDU, CSU and SPD declined by 46 percent . Thus, inclusive participation offers are not a universal remedy . Rather, the parties have to make sure that such offers are really used comprehensively .

Десенсибилизация гиперчувствительных зубов – обязательная часть вашего протокола работы с пациентом во время стоматологического приема

The process of eliminating hyperesthesia of hard dental tissues is a standard method of pathogenetic treatment in conservative dentistry. Patients of almost all age groups are faced with increased tooth sensitivity (hypersensitivity) and in most cases it is one of the symptoms of other pathologies.This is the reason for the constantly growing interest of scientists and clinicians in the problems of desensitization of teeth, which is undoubtedly is the first step in the rehabilitation process for patients with various dental pathologies. Features, hyperesthesia of hard dental tissues requires etiotropic treatment. However, we have the opportunity to influence the pathogenetic link and eliminate the significant symptoms of the disease by reducing dentinal permeability (minimizing the hydrodynamic processes that cause a painful reaction) directly at the dental appointment. Desensitizers and fluoride-containing agents are very effective in solving this problem. There is no doubt that the dentist needs to be well versed in the active ingredients of desensitizing agents, their mechanisms of action, significant advantages and indications for use. There is no universal remedy. Some patients need more than one type of treatment at the same time. Our extremely positive and long-term experience of using the medications of the VOCO company (Germany) will help to make unquestionable and right choice of drugs to eliminate dental hyperesthesia.

СОСТОЯНИЕ И ПРЕДЛОЖЕНИЯ ПО ПЕРСПЕКТИВЕ РАЗВИТИЯ СРЕДСТВ ДОСТАВКИ НОСИТЕЛЕЙ СВЕДЕНИЙ ОГРАНИЧЕННОГО ДОСТУПА

The object of research is to ensure the protection of information from unauthorized access. The subject of the study is to ensure the protection of information from the threat of compromise when delivered into the special case by courier. The purpose of the study is to develop proposals for improving the devices of delivery of carriers of information of limited access by courier in the Armed Forces of the Russian Federation. The methodology of research is based on modeling of situations of transportation of information carriers and a systematic approach to methods and means of protection of state secrets. Proposals were outlined to improve the means of delivery of carriers of limited access information, in fact two promising studies. The first area of research is the development and implementation of an automated system in the army of transportation of types of carriers of information of limited access that are used today in the army. The second direction of research is the development and replacement of types of carriers of information to the new ones made of materials with self-destructive structure under certain conditions. The analysis of technical solutions for the automated transportation system. It was determined a universal remedy for the destruction of carriers of information is a combustible mixture, providing the combustion reaction according to the type of self-propagating high-temperature synthesis. To protect the environment and courier from the combustion process justified the use of composite heat resistant materials. Technical means of recording parameters indirectly characterizing the presence of delivery threat factors were identified. The main working elements of the model of the system of transportation and destruction of documents are formulated. The tests of the demonstration sample of the special case were carried out, which show the rationality of approaches in the development and design of the system. Application of the developed delivery system can be a special unit of the Armed Forces of the Russian Federation provides delivery of carriers of information of limited access unit of the service of protection of state secrets of the Army, Federal guard service, Federal security service, the State courier service of the Russian Federation, security agencies of banks and private firms.

Accommodation of Ethnic Diversities and Nurturing Unity in Ethiopia: Appraising Benishangul Gumuz Regional State Practice

Federalism as a political idea has become increasingly important as a way of peacefully reconciling the principles of unity and diversity typically in multi-national states. Actually, federalism is not a universal remedy for all challenges of ethnic diversity or ethnic conflicts rather it has considered as a means to achieve the end particularly in ethnically heterogeneous states. Therefore, the very objective of this paper is to critically examine the actual practices of unity in diversity at Benishangul-Gumuz regional state (hereafter used as BGRS). In this context, this paper investigate in detail policies and institutions designed for accommodation of ethnic diversity in the study region. Based on the information gained through the various research instruments the writer concluded that non-indigenous ethnic groups are in a better manner accommodated at Kebele level of government than Woreda and regional levels of government in BGRS. Therefore, failure to adequately accommodate non-indigenous ethnic groups particularly in the regional legislative and executive organs and Woreda executive organ of the government in its part challenging the unity of BGRS. Keywords: Federalism; Accommodation of Diversity; Ethnic Diversity; Ethnic Unity; BGRS; Indigenous and Non-indigenous Ethnic Group DOI : 10.7176/RHSS/10-1-01 Publication date: January 31 st 2020

Joining two worlds - When academia meets real life and vice versa

Abstract Partnerships between academic institutions and actors outside of academia have for some time been considered a universal remedy for solving complex issues in a wide range of fields; ranging from themes as different as commercial developments in innovation clusters to reducing social inequalities or working against climate change. Such partnerships are strongly encouraged by governing bodies, and are sometimes prerequisites for being eligible as applicants for funding schemes like H2020. A proof of the impact this model of cooperation has had, is the fact that partnership is the only organisational structure that has been elevated to be part of the UN17 goals for sustainable development. Throughout history, academia has had a complex relationship with the society to which it belongs. On the one hand, academia depends on being seen as valuable, often through visible and concrete impact on society. On the other hand, within academia there is a strong norm of academic freedom stating that such freedom is best accommodated for through a certain degree of insulation between academia and society. This way of understanding academic freedom is an important cornerstone of the Humboltian university ideals as well as in the Mertonian CUDOS norms. Practice and policy actors may also find partnerships with academia complex to navigate. However, such partnerships can be valuable through ensuring that policies and developments are based on research findings and best practices. Furthermore, academics may educate and train practitioners, and evaluate and do research on their initiatives. However, partnerships can also be challenging for practitioners, as academics have to follow strict principles for research design and have little room for holding back results that may put the practitioners in a bad light. In this presentation the complex relationships between academia and practice are presented, both by examining advantages and by taking a critical stance.

Secret Cures of Slaves: People, Plants, and Medicine in the Eighteenth-Century Atlantic World

Secret Cures of Slaves: People, Plants, and Medicine in the Eighteenth-Century Atlantic World

Mitigation of salinity in chickpea by Plant Growth Promoting Rhizobacteria and salicylic acid

For growth or development of pulses, biotic and abiotic environmental factors are more conspicuous under stress conditions. For the survival against abiotic stresses, salicylic acid (SA) is reported a universal remedy. At the Soil Bacteriology Section, Ayub Agricultural Research Institute, Faisalabad, a pot study was conducted to monitor the role of Plant Growth Promoting Rhizobacteria (PGPR) and Salicylic acid in chickpea under salt stress. Eight treatments including control PGPR inoculation and Salicylic acid with their different combination were used. Results revealed that positive response of PGPR on productivity of chickpea but more enunciated response about grain yield was observed with the combined application of SA and PGPR compared to control. Growth parameters i.e root length, root mass, number of nodules and shoot mass were highly affected where SA was applied along with PGPR. From the study, it is proposed that under salt stress the combination of SA + PGPR can be a suitable practice for more production of chickpean Pakistan.

유엔 자의적 구금 실무그룹(UN WGAD)의 준사법적 개인진정 절차를 통한 보편적 인권침해 구제

유엔 자의적 구금 실무그룹(UN WGAD)의 준사법적 개인진정 절차를 통한 보편적 인권침해 구제

Skills Improvement of Teachers in Technical Colleges for Sustainable National Development in Nigeria: Training and Retraining a Universal Remedy

The current study examined training and retraining for skills improvement of teachers in technical colleges for sustainable national development in Nigeria. Three research questions and three hypotheses were raised for the study. A descriptive survey research design was adopted for the study. The population of the study comprised 273 technical teachers in 9 approved technical colleges in Lagos state. A sample of 90 technical teachers was used for the study. A 20-item structured questionnaire constructed by the researchers was used for data collection. Reliability was tested using Cronbach Alpha and a value of 0.87 was obtained. The data collected were analysed using descriptive statistics of the mean and standard deviation to answer research questions. Independent t-test was used to analyse three hypotheses at 0.05 levels of significances. The findings revealed that teachers perceive the availability of training and retraining programmes and sustainable national development can be achieved through training and retraining of teachers as training and retraining programmes can improve teachers’ skills of duties performance. The researchers therefore concluded and recommends that more efforts should be made by relevant bodies such government, higher institutions, professional bodies and among others to put in place more training and retraining programmes for teachers of technical colleges and they should also be encouraged to attend and participate in such programmes to improve their skills in order enable them to function effectively for sustainable national development to be achieved.

Lessons learned from using a decision-support tool for precision placement of conservation practices in six agricultural watersheds in the US midwest

While conservation of natural resources on agricultural landscapes has been a priority for public agencies for more than 80 years, the ability of conservation planners to place conservation practices for enhanced environmental benefits remains elusive. To increase both adoption of conservation practices and efficient use of conservation funding, conservation planners are turning to decision support tools (DSTs), such as the Agricultural Conservation Planning Framework (ACPF). However, less is known about how DSTs facilitate a whole-landscape approach to conservation planning, and the strategies that are employed by conservation planners to engage with producers using new GIS-enabled planning technologies. With the goal of contributing to both the policy and practice of precision conservation, we present findings from semi-structured in-depth interviews conducted with 21 conservation professionals in six watersheds in the US Midwest. Results suggest that the ACPF encourages conservation professionals to think at a watershed scale, supports their approach to conservation planning, and helps them in watershed planning and stakeholder engagement. Results also highlight the importance of conservation professionals employing a suite of strategies, such as being mindful of the scale of producer engagement (i.e., single farm vs community based) and accounting for producers' personalities, to create ‘enabling conditions’ for producer engagement when adopting a precision approach to conservation. Policy recommendations for precision conservation technologies include the need to streamline and expedite the process of conservation delivery, and that DSTs are a means to an end, but not a universal remedy, because conservation planning is most effective when localized interactions of rural landscapes and social dynamics are considered in an adaptive approach.