Uniform Particle Size Distribution Research Articles

Effect of Liquid Feeding Rate on Carbonation of Precipitated Calcium Carbonate via Continuous Method

Precipitated calcium carbonate (PCC) is an innovative product generated from lime that significantly offers various functional characteristics in fulfilling numerous market demand. PCC is produced by hydrating high-calcium quicklime resulting slurry so-called milk-of-lime and reacting the slurry with carbon dioxide (CO2) via carbonation process. The resulting PCC product is extremely white and typically has a uniform narrow particle size distribution. PCC is available in various crystal morphologies and sizes, which can be tailored to optimize performance in a specific application. The final properties of the PCC can be diversified by controlling processing parameters. In this current work, effect of liquid air pressure corresponding to feeding rate on a formation of PCC was investigated. In enhancing the product yield, the quicklime was initially converted into a solution containing calcium ion (Ca2+) using natural promoter agent. Subsequently, CO2 gas was continuously supplied into the Ca-rich ionic solution, thus inducing carbonation reaction to form PCC. This present work showed the carbonation time of producing PCC was effectively reduced as a function of feeding rate from 15 minutes at 10 psi to only 7 minutes at 50 psi. The PCC yield slightly increased from 19 g to 23 g with increasing the feeding rate from 10 psi to 50 psi, respectively. Morphologically, the PCC particles were dominated by rhombohedral structures at various feeding rates with an indication of intergrowth mechanism. This current finding signified the increasing feeding rate offered a significant reduction of PCC production time that might be efficiently applied by the industrial manufacturers.

Effects of TiAl Alloy as a Binder on Cubic Boron Nitride Composites.

Owing to their extreme hardness, cubic boron nitride (cBN) composites are widely used in cutting applications. The performance of cBN composites is closely related to the characteristics of the binder. Therefore, novel binders must be developed to improve the performance of cBN composites. In the present work, TiAl intermetallics were used as binders to fabricate cBN composites by employing a high-temperature and high-pressure sintering method. The phase transformation, sintering reaction mechanism, thermal stability, and mechanical properties of the resultant cBN composites were investigated. It was found that during the sintering process, Ti atoms preferentially reacted with boron nitride particles, whereas Al atoms enriched and transformed into TiAl3 phases and formed cBN/AlN, AlB2/TiN, and TiB2/TiAl3-layered structures eventually. The composites maintained good oxidation resistance at 1200 °C. A decrease in the particle size of the TiAl binder improved the uniformity of particle size distribution and increased the flexural strength of the composites.

Self-defocusing, Kerr nonlinearity of green light emitting phosphors, Calcium–Strontium bimetallic tungstate nanoparticles decorated rGO

Hydrothermal method has been employed to prepare bimetallic tungstate CaSrWO4- rGO as a 3D/2D nanocomposite with various concentrations such as 0.5, 1 and 5 wt. %. The primary concern of this work is to carryout structural characterization of the synthesized nanocomposite and to investigate its third-order optical nonlinearities. The growth of CaSrWO4 on the surface of rGO sheets with uniform particle size distribution is evident from SEM and is augmented by TEM analysis. The formation of CaSrWO4/rGO nanocomposite is confirmed with the appearance of the D and G band with an increase in the ID/IG ratio as observed in the Raman spectra and with the shift of Ca 2p and Sr 2p singlet towards higher binding energy in the XPS spectra. The linear optical properties exhibit a broad absorption in the UV vis spectra and the drastic fall in the electron-hole recombination rate after the addition of rGO in the composite is signified by the transitions of e-s between the intermediate energy levelsexplicited in the PL spectra. For the first time, CaSrWO4/rGO nanocomposite has been investigated for third-order optical nonlinearities by using the Z-scan method in which the nanocomposite is being irradiated with a Gaussian beam of continuous wave of 532 nm wavelength. Nonlinear absorption of CaSrWO4/rGO nanocomposite exhibits a higher reverse saturable absorption and the two-photon absorption β is calculated to be around 7.2 ⨯ 10−5 (cm/W). CaSrWO4/rGO nanocomposite exhibits a self-defocusing effect in nonlinear regime prioritizing it to be a potential optical limiter.

Enhancement of astaxanthin production in Haematococcus pluvialis using zinc oxide nanoparticles

Today, there is a great interest in using astaxanthin due to its potential health advantages. Application of different types of nanoparticles (NPs) as stress agents to enhance astaxanthin production in Haematococcus pluvialis, a microalgae strain, has been reported in the literature. In this study, the effect of different concentrations of zinc oxide (ZnO) NPs on the enhancement of astaxanthin production in H. pluvialis was investigated. First, ZnO NPs were synthesized from zinc nitrate as the precursor and sodium hydroxide (chemical method), and peel extract of pomegranate (green method) as reducing agents. To study the cell viability and stimulate the astaxanthin production, H. pluvialis cells were exposed to the different concentrations (i.e. 50, 100, 200, and 400 μg.ml−1) of ZnO NPs. The synthesized powders were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and dynamic light scattering (DLS) methods. The characterization results showed that the pure ZnO NPs were successfully synthesized via both methods with uniform particle size distribution. But, the average particle size of the green synthesized ZnO NPs (about 30 nm) was smaller than that of the chemically synthesized ones (about 80 nm). Maximum astaxanthin production (~ 20 mg.g−1 of dry biomass of H. pluvialis) was achieved at 100 μg.ml−1 of green synthesized ZnO NPs exposure to the H. pluvialis in comparison with the control culture after 15 days. However, ZnO NPs concentration above 200 μg.ml−1 was toxic to the microalgae. From these results, it can be concluded that a specific amount of ZnO NPs could be considered as a worthy candidate for the enhancement of astaxanthin production in H. pluvialis.

Poly(aluminum chloride) shell-desensitized cyclotrimethylenetrinitramine explosive core

The high-energy explosive material 1,3,5-trinitro-1,3,5-triazinane, also known as cyclotrimethylenetrinitramine or RDX, is highly impact sensitive, and coatings that produce insensitive composites are of significant interest for multiple applications. Inspired by the use of poly aluminum chloride (PAC) to remove natural organic matter in water, in this study, the hydrolysis and self-polymerization of PAC were used to form an insensitive coating on the crystal surface of RDX. A composite material with good crystal morphology, uniform particle size distribution, and low sensitivity was successfully prepared. The coating layer was observed significant for when 5 wt% PAC was used. Thermodynamic analysis showed good compatibility between RDX and PAC, and the thermal stability of the composite material is similar to that of raw RDX. The crystal morphology was significantly improved due to the reduction of crystal cracks during the preparation process, and the polymer coating around the energy crystals displayed good deactivation characteristics. With the addition of 5 wt% PAC, the sensitivity of the composite particles was significantly reduced. This work proves a successful application of PAC in energetic materials and provides a possible method for desensitizing energetic crystals.

CFD simulation of continuous non-catalytic gas–solid reaction with uniform particle size distribution

Non-catalytic fluidized bed reactors (FBRs) have been utilized in various industries. In this study, a computational fluid dynamics (CFD) model, involving a combination of transport processes, intrinsic kinetics, and flow structure, is established and validated to investigate the continuous gas–solid reaction. The simulated results indicate that the solid conversion rate is determined by the solid reaction rate and the mass flow rate. Traditional interphase transfer models have been proven to overestimate the momentum and mass transfer coefficients, and cause deviations in the predicted results. The gas–solid reaction rate, obtained from the structure-based model, depends on reaction time and bed position owing to the variations in the overall reaction rate constant and the non-uniform gas–solid flow structure. The period longer than twice the time required for complete conversion of particle has little effect on the solid conversion process, because of the higher internal diffusion resistance and the wider residence time distribution of particles. The mass transfer during the bubble phase also contributes to the reaction process. Therefore, this study provides a methodology for the CFD simulation of continuous non-catalytic FBRs.

Novel NiMgOH-rGO-Based Nanostructured Hybrids for Electrochemical Energy Storage Supercapacitor Applications: Effect of Reducing Agents

This paper describes the synthesis and characterization of NiMgOH-rGO nanocomposites made using a chemical co-precipitation technique with various reducing agents (e.g., NaOH and NH4OH) and reduced graphene oxide at 0.5, 1, and 1.5 percent by weight. UV-visible spectroscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, a particle size analyzer, and cyclic voltammetry were used to characterize the composite materials. The formation of the NiMgOH-rGO nanocomposite with crystallite sizes in the range of 10–40 nm was inferred by X-ray diffraction patterns of materials, which suggested interlayers of Ni(OH)2 and Mg(OH)2. The interactions between the molecules were detected using Fourier-transform infrared spectroscopy, while optical properties were studied using UV-visible spectroscopy. A uniform average particle size distribution in the range of 1–100 nm was confirmed by the particle size analyzer. Using cyclic voltammetry and galvanostatic charge/discharge measurements in a 6 M KOH solution, the electrochemical execution of NiMgOH-rGO nanocomposites was investigated. At a 1 A/g current density, the NiMgOH-rGO nanocomposites prepared with NH4OH as a reducing agent had a higher specific capacitance of 1977 F/g. The electrochemical studies confirmed that combining rGO with NiMgOH increased conductivity.

Stability, Microstructure, and Rheological Properties of CaCO3 S/O/W Calcium-Lipid Emulsions.

Calcium carbonate (CaCO3) is a commonly used fortified calcium, but poor suspension stability and easy precipitation seriously limited its food processing and products application. The formation of CaCO3 loaded microparticles based on the form of solid/oil/water (S/O/W) emulsion is a promising method to improve the dispersion stability of CaCO3 in liquid food. In this study, CaCO3, soybean oil, and sodium caseinate (NaCas) were used as the solid, oil, and W phase, respectively. The fabrication involved two steps: the S/O emulsion was prepared by adding CaCO3 into soybean oil by magnetic stirring and high-speed shearing, and then put the S/O crude emulsion into NaCas solution (W phase) to obtain S/O/W emulsion by high-speed blender. The particle size distribution, zeta potential, stability of the microsphere, infrared spectral analysis, and XRD of the S/O/W calcium-lipid microsphere were explored. The stability and rheological mechanism of S/O/W calcium-lipid emulsion were investigated by combining the microstructure, shear rheological, and microrheological properties. It was found that the emulsion particles have more uniform particle size distribution and no aggregation, and the stability of the emulsion was improved with increasing the content of NaCas. The mean square displacement (MSD) curve and solid-liquid equilibrium (SLB) value of S/O/W emulsion increased with the increase in NaCas concentration, and the viscosity behavior is dominant. The results of confocal laser microscopy (CLSM) and cryo-scanning electron microscopy (Cryo-SEM) showed that the three-dimensional network structure of S/O/W emulsions was more compact, and the embedding effect of calcium carbonate (CaCO3) was slightly improved with the increase in NaCas concentration. According to infrared spectrum and XDR analysis, the addition of CaCO3 into the emulsion system caused crystal structure distortion. This study provides a reference for solving the dispersibility of insoluble calcium salt in liquid food.

Antibacterial Activities of Calcareous/TiO2 Nanocomposites

Aims: In the present investigation, To synthesis, characterization and antibacterial activity of Calcareous/TiO2 nanocomposites toward Bacillus, Proteus vulgaris, Micrococcus luteus, Staphylococcus aureus and Escherichia coli.
 Methodology: The resulting Calcareous/TiO2 nanocomposite was synthesized by hydrothermal method. The synthesized nanocomposites were characterized by using XRD, SEM with EDAX, AFM, TEM and UV-Vis absorption spectroscopy. The antibacterial activities of the Calcareous/TiO2 nanocomposite species were checked by using agar well diffusion method.
 Results: The XRD pattern is showed that the diffraction peaks appear in the pattern corresponding to the anatase phase of TiO2. UV-Visible spectrum showed that the blue shifted when compared with bulk TiO2 (3.2 eV). The blue shift might be caused by nanosize effect and structural defect of nanomaterials. AFM image shows the morphology of Calcareous/TiO2 nanocomposites forming sharp particles on the surface. TEM image showed that the particles exhibit a relatively uniform particle size distribution. The average size of the nanocomposites estimated from the TEM image is around 50nm.
 Conclusion: In conclusion, the Calcareous/TiO2 nanocomposites have been successfully synthesized. The prepared nanocomposites were characterized using various analytical tools like XRD, SEM with EDAX, AFM, TEM, UV-Vis absorption spectrum.

Mechanism of Hydrogen Sulfide Drug-Loaded Nanoparticles Promoting the Repair of Spinal Cord Injury in Rats Through Mammalian Target of Rapamycin/Signal Transducer and Activator of Transcription 3 Signaling Pathway

To explore the effect of hydrogen sulfide (H2S) drug-loaded nanoparticles (H2S-NPs) on the mTOR/STAT3 signaling pathway in rats and its mechanism on repair of spinal cord injury (SCI), a new H2S-NP (G16MPG-ADT) was prepared and synthesized. The rats were selected as the research objects to explore the mechanism of SCI repair. The G16MPG-ADT NPs were evaluated by average particle size (APS), dispersion coefficient (DC), drug loading content (DLC), drug loading efficacy (DLE), in vitro release (IV-R), and acute toxicity (AT). It was found that G16MPG-ADT nanoparticles had a uniform particle size distribution with a unimodal distribution, with an average particle size of 186.5 nm and a dispersion coefficient of 0.129; within the concentration range of 8~56 μg/L, there was a good linear relationship with the peak area; and the release rate of the nanoparticles within 16 h~32 h was higher than 50%. G16MPG-ADT NP injection treatment was performed on rats with SCI. Western blotting (WB) and immunofluorescence staining were adopted to analyze the expression levels of mammalian target of rapamycin (mTOR) and signal transducers and activators of transcription (STAT3) protein and the growth of neurites. It was found that G16MPG-ADT can increase mTOR and STAT3 protein levels and promote nerve growth after SCI. Finally, the Basso, Beattie and Bresnahan locomotor rating (BBB) score was to evaluate the recovery effect of rats after treatment. It was found that the recovery effect was excellent after G16MPG-ADT treatment. In summary, G16MPG-ADT has a good effect on SCI repair in rats and can be promoted in the clinic.

Effect of Thin Film to Boost the Electrochemical Properties of LiMn1.5Ni0.5O4

Micrometer-grade spherical LiMn1.5Ni0.5O4(LMNO) particles with a uniform particle size distribution were synthesized by a carbonate coprecipitation method in a continuous stirred tank reactor. LMNO particles were modified by the FeF3 nanoscale thin film. TheFeF3-coated electrodes display superior electrochemical performance at various C rates and temperatures. The FeF3-coated LMNO also had improved thermal and structural stability. The increase in performance is due to the protective effect of the coating layer.

Scalable Synthesis of High Entropy Alloy Nanoparticles by Microwave Heating

High entropy alloy nanoparticles (HEA-NPs) are reported to have superior performance in catalysis, energy storage, and conversion due to the broad range of elements that can be incorporated in these materials, enabling tunable activity, excellent thermal and chemical stability, and a synergistic catalytic effect. However, scaling the manufacturing of HEA-NPs with uniform particle size and homogeneous elemental distribution efficiently is still a challenge due to the required critical synthetic conditions where high temperature is typically involved. In this work, we demonstrate an efficient and scalable microwave heating method using carbon-based materials as substrates to fabricate HEA-NPs with uniform particle size. Due to the abundant functional group defects that can absorb microwave efficiently, reduced graphene oxide is employed as a model substrate to produce an average temperature reaching as high as ∼1850 K within seconds. As a proof-of-concept, we utilize this rapid, high-temperature heating process to synthesize PtPdFeCoNi HEA-NPs, which exhibit an average particle size of ∼12 nm and uniform elemental mixing resulting from decomposition nearly at the same time and liquid metal solidification without diffusion. Various carbon-based materials can also be employed as substrates, including one-dimensional carbon nanofibers and three-dimensional carbonized wood, which can achieve temperatures of >1400 K. This facile and efficient microwave heating method is also compatible with the roll-to-roll process, providing a feasible route for scalable HEA-NPs manufacturing.

Preparation and anti-tumor activity of PEG-PCL polymersomes loaded with curcumol derivative in HepG2 cell line

Curcumol is a natural plant product with anti-tumor properties. However, the clinical application of curcumol is limited by its low water solubility. In this study, we synthesized a curcumol derivative 2e (CD-2e) with improved bioavailability and evaluated its cell growth-regulating activities in human hepatoma HepG2 cells, a liver cancer precursor cell line. Using the clone formation assay, we detected that CD-2e inhibits proliferation and activity of HepG2 cells more effectively than curcumol. Flow cytometry analysis indicated that CD-2e can induce HepG2 cell apoptosis and arrests cell cycle in S phase. Acridine orange-ethidium bromide(AO-EB) double staining indicated that CD-2e triggers HepG2 cell apoptosis in a time-dependent manner. Additionally protein expression analysis showed that CD-2e treatment reduced expression levels of c-Jun N-terminal kinase 1 (JNK1) and its phosphorylated form, P-JNK1. PEG-PCL polymersome carrying CD-2e (PEG-PCL-CD-2e) were generated to improve drug delivery. The prepared PEG-PCL-CD-2e had a uniform particle size distribution, with an average particle size of about 190 nm, and good in vitro stability. The drug release and cell uptake experiments showed that PEG-PCL-CD-2e can rapidly release CD-2e in a weak-acid environment in vitro. Pharmacokinetic studies indicated that, compared with free CD-2e, PEG-PCL-CD-2e enhanced Cmax and Area Under Curve (AUC) (0-∞) by about 1.93-fold and 2.45-fold. The T1/2 was prolonged to 2.59 ± 0.03 h.

The emulsifying stability of soy hull polysaccharides with different molecular weight obtained from membrane-separation technology

Abstract Polysaccharides are macromolecules used for food development, and their further separation into different molecular weights allows their broader application in the food industry. Here, we performed microwave-assisted ammonium oxalate extraction of soy hull polysaccharide (SHP; MASP), followed by their separation and purification using membrane-separation technology and analyses of the emulsifying stability and MASP mechanism at different molecular weights. Additionally, we compared the composition and structural differences in SHP components and evaluated the separation and grading-emulsification stability properties of the membrane-emulsified components. The results showed improved emulsification stability properties of high molecular weight SHPs that had been separated and purified by membrane separation, with the formed emulsion exhibiting a high degree of viscosity, uniform particle-size distribution, smaller particle size, less interfacial tension, and a high Zeta potential. Moreover, the chemical composition, monosaccharide composition, and molecular weight of SHP were different.

Phase field simulation of abnormal grain growth mediated by initial particle size distribution

The uniform initial particle size distribution was considered to be an important condition for the preparation of dense ceramics. With the rapid development of templated grain growth method, it is necessary to add large template particles into small matrix to promote the epitaxial growth of grains. However, abnormal grain growth will inevitably occur in this process. In this work, a phase field method was employed to study the growth behavior of the large grains into the small matrix. The effect of initial particle size distribution on the grain growth kinetics was investigated. Our simulations revealed that the growth rate of large grains slowed down as the initial grain size distribution widened. Regulating the initial grain size distribution will be an effective way to control abnormal growth of grain. It was found that the growth rate of a large grain was proportional to the number of surrounding grains. These results have implications for the design of the functional ceramics with a target grain microstructure.

Phase-change mesoporous Prussian blue nanoparticles for loading paclitaxel and chemo-photothermal therapy of cancer

Complete treatment of cancer remains a major challenge today. Herein, a biocompatible drug delivery system named as PCM + PTX@mPBs/PEG was constructed. In this system, Paclitaxel (PTX) was blended with phase-change material (PCM) and loaded in mesoporous Prussian blue nanoparticles (mPBs), and chelated with polyethylene glycol at surface. The blank PCM@mPBs/PEG had uniform particle size distribution, large pore size to load drug, excellent photothermal efficiency and good biocompatibility. After loading PTX, PCM + PTX@mPBs/PEG was demonstrated with a high loading capacity and the drug presented temperature-responsive release characteristics. In addition, PTX can be released under the exposure of an NIR laser. In vitro cell experiments showed that nanoparticles can be exposed to near-infrared irradiation to increase uptake in cells, which enhanced anticancer activity. After tail vein injection of PCM + PTX@mPBs/PEG suspension in tumor-bearing mice, PCM + PTX@mPBs/PEG can accumulate at the tumor site through passive transport. The tumor was effectively suppressed by phototherapy and chemotherapy with few side effects. In summary, compared with photothermal therapy or chemotherapy alone, the prepared PCM + PTX@mPBs/PEG showed synergistic photothermal and chemotherapeutic effects on cancer treatment of mice.

Kinetics guided synthesis and performance of monodisperse zeolite LTA microspheres

Monodisperse zeolite microspheres hold great potential for wide industrial applications, but the existing preparation methods could hardly afford a uniform particle size distribution. Herein, the authors, for the first time, achieved the synthesis of monodisperse zeolite microspheres possessing high sphericity and tight particle size distribution with coefficient of variation (CV) less than 5%. Unlike previous methods that produce macroporous zeolites, the current strategy featured as shape-preserving steam assisted crystallization (SAC) successfully transforms aluminum and sodium source impregnated mesoporous silica microspheres into monodisperse zeolite LTA microspheres with tunable particle size between 10 and 30 μm. Spatiotemporal control of crystallization kinetics with balanced silica dissolution and zeolite nucleation is found to be essential for authentically maintaining the monodisperse spherical morphology, with larger-sized silica leading to higher zeolite sphericity. The pore size of the initial silica affects the resulting zeolite crystallinity, viz., larger silica pore size leads to higher zeolite crystallinity. Evolution of the zeolite microspheres involves synchronized silica dissolution and LTA crystallization in trapped domains facilitated by the intermediate, homogenously dispersed gel matrix, allowing to inherit the parent silica morphology. The LTA zeolite microspheres exhibit extremely high crystallinity, mechanical strength, thermal stability, and excellent air separation performance.

The development of Moringa leaves effervescent granules with effervescent agent of citric acid and sodium bicarbonate

Moringa leaves are part of Moringa Oleifera, which have a high antioxidant content, therefore, it is beneficial for overcoming free radicals in the body. Furthermore, the leaves contents have the potential to be developed into a functional drink in the form of effervescent granules. The important aspects influencing the physical characteristics, stability, and acceptability of granule is the type and ratio of the effervescent agent. In this study, citric acid and sodium bicarbonate were used as effervescent agents because they both provide acceptable texture and mouthfeel. This study aimed to develop an effervescent granule formula of Moringa leaves and to optimize the molar ratio of citric acid and sodium bicarbonate as the effervescent agent. Three molar ratios of citric acid and sodium bicarbonate were optimized, namely 1:3.11 (Formulation 1), 1:3 (Formulation 2), and 1:2.93 (Formulation 3). These formulations were developed using the wet granulation method. The results showed effervescent granules of the three formulations exhibited good flowability and uniform particle size distribution. Furthermore, formulation 3 showed better granule flow characteristics than the others. The results after reconstitution showed the granules were quickly dispersed within 207-234 secs, the pH of the preparation ranged between 5.74-5.92 (neutral pH), the viscosity was between 326-333 cps, and exhibited dilatant flow characteristics. Also, the organoleptic and sensory evaluation results showed formulation 3 was the most acceptable in terms of color, taste, aroma, and texture. Based on these findings, it was concluded that formulation 3 which used (citric acid ratio, sodium bicarbonate 1:2.93) was the optimal formulation.

Synthesis of imidazoline biosurfactants and application as an asphalt emulsifier

This study synthesized an imidazoline biosurfactant (IM-BioSurf) from biomass residue and tetraethylenepentamine in two steps. Its structure was characterized by Fourier transform infrared spectroscopy (FT-IR) and proton NMR spectra (1H-NMR). The critical micelle concentration (CMC) and surface tension (γCMC) of IM-BioSurf were measured, as well as the interfacial tension between the IM-BioSurf aqueous solution and asphalt. At 298 K, the CMC and γCMC of IM-BioSurf were 4.95 g/L and 38.27 mN·m−1, respectively. IM-BioSurf significantly reduced the oil-water interfacial tension, thus conferring excellent surface and interfacial activity. Emulsified asphalt prepared with the IM-BioSurf emulsifier had excellent storage stability and a uniform particle size distribution with an average size of 1.55 μm. In addition, the influence of IM-BioSurf on evaporation residue performance indicators was very small. Moreover, micro-surface tests showed that the emulsified asphalt acts as an excellent binder in asphalt mixtures. Most importantly, the biomass residue used to prepare IM-BioSurf can be readily obtained at low cost. As such, it is environmentally friendly, sustainable, and can greatly reduce the cost of emulsifier production. IM-BioSurf has broad application prospects as an asphalt emulsifier.

Superhydrophobic surface of glass powder derived from wet milling with aliphatic chemicals modification

Glass frit has emerged recently as a promising material for incorporation in adhesive of electronic components owing to its high sealing density, environmental stability and easy processing. This requires the glass surface to be hydrophobic to ensure high dispersity, grinding uniformity, and high-temperature sintering performance of the glass frit. However, the glass surface is usually hydrophilic. In this work, we developed a wet milling method to effectively produce hydrophobic glass powder by using aliphatic chemicals modification. We employed a series of aliphatic chemicals containing nucleophilic functional groups to prepare ultrafine lead aluminosilicate electronic glass powders. The nucleophilic substitution reaction of amino groups, carboxylic acid groups, hydroxyl groups and phosphoric acid groups reduces the hydroxyl content on the surface of the glass powder to 0.10 mg/m2, and generates steric hindrance and hydrophobicity (contact angle: 153.0°) through the long carbon chain. The obtained powder therefore shows a uniform particle size distribution, anti-agglomerated property, and maximum 25 °C lower hemispheric point temperature compared to powder prepared by conventional hydrophilic milling method. This work provides a versatile method to simultaneously control the structural and surface properties of glass powders at their formation stage.